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Preparation utilizing compatibility prescription of effective parts of rhizoma coptidis and rhizoma drynariae in treatment of periodontitis

A technology of effective parts, Drynariae, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve the lack of pharmacological research, stability, and controllability is difficult Realization and other issues, to achieve the effect of no toxic side effects, broad clinical application prospects, and significant curative effects

Active Publication Date: 2014-10-08
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, these prescriptions lack the support of pharmacological research, and from the perspective of preparation quality, the stability and controllability of such drugs are also difficult to achieve

Method used

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  • Preparation utilizing compatibility prescription of effective parts of rhizoma coptidis and rhizoma drynariae in treatment of periodontitis
  • Preparation utilizing compatibility prescription of effective parts of rhizoma coptidis and rhizoma drynariae in treatment of periodontitis
  • Preparation utilizing compatibility prescription of effective parts of rhizoma coptidis and rhizoma drynariae in treatment of periodontitis

Examples

Experimental program
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Effect test

Embodiment 1

[0036] The ingredients by weight of raw materials in this example are: 15 parts of water extract of Coptis Rhizoma (80% berberine) and 8 parts of water extract of Rhizoma Drynariae (30.71% naringin); 1 part of gelatin and 2 parts of glycerin.

Embodiment 2

[0038] The ingredients by weight of raw materials in this example are: 14 parts of water extract of Coptidis rhizome (80% berberine) and 9 parts of water extract of drynariae (30.71% naringin); 1 part of gelatin and 2 parts of glycerin.

Embodiment 3

[0040] The ingredients by weight of raw materials in this example are: 13 parts of water extract of Coptis Rhizoma (80% berberine) and 10 parts of water extract of Rhizoma Drynariae (30.71% naringin); 1 part of gelatin and 2 parts of glycerin.

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Abstract

The invention relates to a preparation utilizing a compatibility prescription of the effective parts of rhizoma coptidis and rhizoma drynariae in treatment of periodontitis. The preparation comprises the following components by mass: 10-15 parts of a rhizoma coptidis effective part's water extract with a berberine content of more than 80%; and a rhizoma drynariae effective part's water extract with a naringin content of more than 30.71%. The preparation can be prepared into a ''rhizoma coptidis-rhizoma drynariae tooth strengthening capsule'' for systemic administration, or can be added with hydroxyethyl cellulose, concentrated glycerol, polyacrylic resin and other auxiliary materials to make a novel topical Chinese medicinal long-acting compound ointment ''rhizoma coptidis-rhizoma drynariae tooth strengthening ointment'', and a syringe administration mode is easy for operation at local parts of a periodontal pocket. With a good therapeutical effect on periodontitis, the preparation provided by the invention has the characteristics of small prescription, significant curative effect, no toxic or side effect. Especially in local application, after long-term use, the anti-inflammatory effect is similar to that of minocycline hydrochloride ointment (Periocline), but the osteogenic effect is obviously superior to that of Periocline. Thus, the preparation is a novel oral Chinese patent medicine with long-term efficacy and usability similar to western medicines.

Description

technical field [0001] The present invention relates to the application and preparation of a Chinese patent medicine, in particular to a preparation for treating periodontitis by using the compatible prescription of the effective parts of Coptis Rhizoma and Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome. , for the treatment of periodontitis. Background technique [0002] Periodontitis is the disease with the highest incidence rate in the oral field, and it is also a difficult disease in the field of oral medicine. It has become the main cause of tooth loss in adults. At the same time, it also induces many systemic diseases, such as rheumatism, heart disease, blood disease, diabetes, etc., and is considered to be the third biggest killer threatening human health after cancer and cardiovascular and cerebrovascular diseases. Periodontitis is a chronic bacterial infectious disease. The destruction of perio...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K47/38A61K47/32A61K47/10A61P1/02A61P29/00A61K36/11A61K31/4375A61K31/7048
Inventor 李昂王嗣岑苟建重孙俊毅
Owner XI AN JIAOTONG UNIV
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