5 results about "Dimethylamine hydrochloride" patented technology

The application belongs to the technical field of organic synthesis, and specifically discloses a preparation method of dimethyl diallyl ammonium chloride, which comprises the following steps: under the condition that water exists, dimethylamine, an alkaline carrier and allyl chloride are mixed and subjected to a contact reaction to obtain a crude tertiary amine; the alkaline carrier comprises a carrier body and a carbonic acid alkali metal salt loaded on the carrier body; under the condition that an organic solvent exists, the crude tertiary amine and allyl chloride are mixed and subjected to a contact reaction. The method can effectively reduce the hydrolysis of allyl chloride and the generation of dimethylamine hydrochloride in the reaction process, the dimethyl diallyl ammonium chloride product contains almost no other hydrochloride impurities, and the reaction efficiency, the yield and the purity of the dimethyl diallyl ammonium chloride are improved.

This invention relates to a dimethylamine-modified tetranuclear heterometallic cluster compound, its preparation method, and its application. The invention is intended for the field of electrocatalytic oxygen evolution and relates to a compound, its preparation method, and its application. The purpose of this invention is to address the problem of hydrogen energy shortage. The dimethylamine-modified tetranuclear heterometallic cluster compound has the molecular formula [(CH3)2NH2][Ni(H2O)6][{NaNiSbW(OH)4(H2O)6}{SbW8O 30 Na₂[SbW₁₉O]·2H₂O has a molecular weight of 2861.62. It is used for alkaline electrocatalytic oxygen production. Preparation method: Prepare Na₂[SbW₁₉O]₂. 33 Precursor; Na9[SbW9O 33 The precursor was dissolved in deionized water, nickel nitrate was added, and the mixture was stirred. Terephthalic acid was added, and the mixture was stirred again. NaOH solution was added dropwise, and the reaction was allowed to proceed for 2 hours. After cooling, the mixture was filtered, and dimethylamine hydrochloride was added. The mixture was then evaporated at room temperature to crystallize. Hexagonal yellow crystals appeared after three days, yielding the product. The overpotential of the dimethylamine-modified tetranuclear heterometallic cluster compound of this invention can reach 39.7 mV. The Tafel slope is 19.75 mV / dec. The slope of the fitted straight line is 4.51 mF / cm. 2 Electrochemical transfer resistance: 1.9Ω.

The application relates to a preparation method and application of a formamidinium calcium perovskite photoelectric film, and the preparation method comprises the following steps: preparing a lead iodide solution containing a sacrificing agent, and coating to form a film; then, a formamidinium hydroiodide solution is coated on the film to obtain an intermediate phase film, and the formamidinium calcium perovskite photoelectric film is prepared through annealing; or, a lead iodide solution containing formamidinium hydroiodide and a sacrificing agent is prepared, and the solution is coated to form a film, and the formamidinium calcium perovskite photoelectric film is prepared through annealing; wherein the sacrificing agent is at least one of dimethylamine hydrochloride, dimethylamine hydroiodide, N-methylethylamine hydrochloride, N-methylethylamine hydroiodide, diethylamine hydrochloride or diethylamine hydroiodide. Compared with the prior art, the sacrificing agent is mixed with a perovskite precursor solution in the application, high-quality formamidinium calcium perovskite photoelectric films are obtained through annealing, the sacrificing agent used can be completely volatilized in the process of forming the perovskite film, narrow-band-gap pure formamidinium calcium perovskite films are obtained, and the problem of phase separation is solved.

The application discloses a preparation method of fosnetupitant and intermediates thereof, which comprises the following steps: taking an amino thiophene compound II-a as a starting material, generating a chlorinated compound II-d through a plurality of reactions such as urea formation, ring closure and chlorination, then selectively catalytically hydrogenating and removing the chlorine at the C-4 position of the pyrimidine ring to obtain a compound II-e, and then preparing an intermediate compound II through ester hydrolysis and condensation with dimethylamine hydrochloride; taking a compound III-a and a compound III-b as starting materials to generate a substitution reaction to obtain a compound III-c, and then reducing the compound III-c through catalytic hydrogenation to obtain an intermediate compound III; and further generating a Buchwald-Hartwig coupling reaction of the intermediate compound II and the intermediate compound III to obtain a finished product of fosnetupitant. The preparation method can not only reduce the cost, simplify the synthesis route, control each reaction and improve the total yield, but also is more economic and environmental. Meanwhile, the application improves the stability and reliability of the process, and provides a guarantee for industrialized scale production of fosnetupitant.

The application provides a synthesis method of relugolix, comprising the following steps: reacting compound 2 with di-tert-butyl dicarbonate to obtain compound 3; reacting compound 3 with dibromohydantoin to obtain compound 4; reacting compound 4 with dimethylamine hydrochloride to obtain compound 5; hydrolyzing compound 5 to obtain compound 6; condensing compound 6 with 6-methoxy-3-aminopyridazine to obtain compound 7; deprotecting the amino group of compound 7 to obtain compound 8; performing reductive amination on compound 8 with 2,6-difluorobenzaldehyde to obtain compound 9; performing nitro reduction on compound 9 to obtain compound 10; and reacting compound 10 in the presence of carbonyldiimidazole and methoxyamine hydrochloride to obtain relugolix. The synthesis method is more efficient than prior art, avoids potential genotoxic impurities in the prior art, has mild process conditions, high reaction yield in each step, effectively reduces industrial production cost and safety risk, and is suitable for industrial production.