38results about How to "Efficient treatment effect" patented technology

The invention provides an elastic membrane, and a preparation method and application thereof. The elastic membrane comprises a silicone rubber and a medicine. The medicine is coated inside the silicone rubber in a mode of a medicine storage area, and the medicine comprises estrogen. The elastic membrane achieves an efficient therapeutic effect through micro-release of the medicine, and the medicine release is more stable. The elastic membrane has a longer medicine release cycle and better slow release capacity and is used for treatment of uterine cavity damage in a medicine slow-release system. The method for preparing the elastic membrane is simple, raw materials are easy to obtain, the price is low, and industrial large-scale production application is facilitated.

The present invention provides a pharmaceutical composition containing sunitinib and its formulation and application, on the basis of the original sunitinib, further adding at least one tyrosine kinase receptor inhibitor, especially apatinib Nib and / or Axitinib can produce a very significant synergistic effect with it, thereby significantly inhibiting the proliferation of cancer cells, and has a very significant killing efficiency on cancer cells. The pharmaceutical composition provided by the present invention can obviously improve the problem of severe drug resistance caused by the simple use of sunitinib in the prior art and the problem of significantly reduced therapeutic effect when reducing the conventional dosage of sunitinib, greatly It improves the efficiency of clinical treatment, reduces the side effects of treatment for patients, provides a new solution for clinical treatment, and has a very broad market prospect and extremely important social significance.

The purpose of the invention is to provide a Pudilan children's antiviral oral pellet gel and a preparation method thereof. The preparation method comprises the following steps: adopting a gel matrix, extracting Radix Scutellariae, Herba Taraxaci, Corydalis bungeana Turcz. and isatis root, preparing pellets by using extracted effective components, and uniformly dispersing the pellets in a gel. The prepared gel can be a solid gel, a semisolid gel or a xerogel. The method effectively covers the bad smell of medicines, solves the mouthfeel problem of the medicines, and allows the sweet oral pellet gel loved by children to be prepared, and the sweet and smooth mouthfeel of the oral pellet gel makes children easily take the medicine. Traditional Chinese medicines are combined with the gel dosage form to improve the children's administration long-term single dosage form, and the oral pellet gel has the efficacies of heat clearing, detoxification, antibiosis and inflammation prevention, and also has the advantages of high content of the effective component, small administrating dosage, stable preparation and good curative effect.

A method for preparing ultra-high drug-loaded nanoparticles by means of sequence precipitation-complex coacervation. The method comprises: first, mix a first reactant and a second reactant in a first reaction vessel (1), and then precipitate active pharmaceutical ingredients in the first reaction vessel (1) to form cores of drug nanoparticles; the reaction product in the first reaction vessel (1) quickly flows into a second reaction vessel (2) to mix with a third reactant; and after undergoing a complex coacervation reaction, shell materials are deposited on the surfaces of the cores of drug nanoparticles so as to form ultra-high drug-loaded nanoparticles having a core-shell structure.

The invention provides an amphiphilic graft copolymer based on hyaluronic acid, its preparation method and application. The copolymer of the present invention includes: hyaluronic acid (HA) as a matrix, deoxycholic acid (DCA) grafted on the backbone, methoxypolyethylene glycol (mPEG) units and N-acetyl-L-half Cystine (NAC) group. The invention also provides a preparation method of the copolymer, wherein the copolymer is prepared by modifying HA with mPEG, DCA and NAC. The invention also provides a hemostatic sponge, a drug carrier and a drug composition prepared from the copolymer. The copolymer of the present invention has good biocompatibility, fast water absorption, active and passive dual targeting and redox conversion, so it can be used to prepare fast water-absorbing hemostatic sponge and anti-cancer drug release carrier, and realize prolonged blood circulation, high intake and Rapid drug release can effectively increase the drug concentration in tumor cells, and has broad application prospects.

Disclosed are: a method for producing a cell mass containing a cytokine-induced killer (CIK) cell, which is characterized by comprising the step of culturing a cell mass containing a cell that can be differentiated into a CIK cell in the presence of a fragment of a fibronectin; and others.

The invention discloses a polyamino acid sound sensitizer as well as its preparation method and application. The main chain structure of the polyamino acid sonosensitizer of the present invention is aspartic acid grafted with protoporphyrin, which has good biocompatibility, and the side bond of protoporphyrin modified on the water-soluble polyaspartic acid greatly improves The solubility of protoporphyrin is improved, the blood compatibility of the sonosensitizer in the body and the accumulation amount of the lesion are increased, so as to produce a better therapeutic effect and realize efficient and safe tumor treatment. The present invention also provides a sound sensitizer nanovesicle and its target-modified sound sensitizer nanovesicle, which has the effect of high efficiency and low toxicity, and provides a new type of sound sensitizer with excellent performance for the development of safe and efficient sonodynamic therapy. Sensitizer materials, and by modifying specific antibodies or ligands on their surface, improve their aggregation at the target site.