111results about How to "Easy to ingest" patented technology

The invention discloses a heat pump driving solution moisture regulating and domestic hot water preparing system realizing energy balance. The system is characterized by comprising a heat pump circulating system and a solution moisture regulating system, the heat pump circulating system comprises a frequency-variable compressor, a four-way reversing valve, a solution cooling condenser, a stop valve, a throttling valve and an evaporator, and a water-cooling condenser is introduced to prepare domestic hot water; the solution moisture regulating system comprises a dehumidifier, a regenerator, a solution pump, a solution heat exchanger, a solution valve and a fan. The heat pump driving solution moisture regulating and domestic hot water preparing system combines a solution circulating system, the heat pump system and a domestic water preparing system, and domestic water is prepared by utilizing redundant condensing heat of a refrigerant while solution moisture regulating is realized through driving of a heat pump, so that system energy balance and effective utilization of energy resources are realized, and comprehensive performance of the system is improved.

The invention discloses a method for improving solubility of poorly soluble drugs using silicon nanocarriers. The technical points are as follows: an aqueous solution of silane is used as an aqueous phase, a mixed solvent of Triton X-100, alkanes, alcohols and pore-forming agents is used as an oil phase; under stirring conditions, the aqueous phase is added into the oil phase to form a water-in-oil reversed-phase microemulsion; after the microemulsion is stabilized, tetraethoxysilane (TEOS) and ammonia hydroxide are added to trigger polymerization reaction to form silicon nanoparticles at an emulsion interface; acetone is added to stop reaction, the silicon nanoparticles are added to an acetic acid solution to dissolve pore-forming agents after cleaning, and mesoporous silicon nanoparticles are obtained. The prepared mesoporous silica nanoparticle has a hollow structure with a particle size of 20 to 100 nm, a center cavity diameter is 5 to 20 nm, and a mesoporous diameter is 1 to 10 nm. The hollow mesoporous nanoparticles have the advantages that the poorly soluble drugs can be encapsulated, drug solubility and bioavailability are improved, and a new platform is provided for solubilization of the poorly soluble drugs.

Disclosed is kind of Vinorelbine solid lipid nanoparticles which comprise (by weight percent) vinorelbine 1-25%, grease material 30-90%, phospholipids 5-50% oleinic acid 0-20%. The preparing process consists of melting liposome material through water-bath, dissolving phosphatides, oleic acid and Vnorelbine with ethanol, dropping into the liposome material, removing ethanol under decompression condition, cooling down and freezing, placing into pH 2-5 aqueous phase, triturating and homogenizing the turbid liquor to obtain the freeze-dried preparation with improved anticancer reactivity of Vinorelbine.

The invention discloses a spherical nucleic acid fluorescent probe for telomerase activity detection and a preparation method and use thereof. The spherical nucleic acid fluorescent probe takes a goldnano particle as a carrier, and a double-stranded DNA is loaded on the surface of the carrier; one single-stranded DNA of the double-stranded DNA is a TP-chain long chain, the TP-chain long chain comprises a telomerase primer TP, a sequence and an auxiliary sequence complementary with a telomerase amplification sequence in turn from a 3' end; the other single-stranded DNA of the double-stranded DNA is a FL-chain short chain decorated by fluorochrome complementary with the TP-chain long chain. The spherical nucleic acid fluorescent probe overcomes heterogeneity of tumor cells, achieves universality detection of tumors on a molecular level, and can achieve cross-platform detection of the tumors from a molecule, a cell and a tissue to a living body and visual navigation for tumor surgeries.

The invention discloses a peptide dentritic macromolecular drug and a preparation method and application thereof, and belongs to the field of biomedicine. The drug comprises a peptide dentritic macromolecular skeleton, and terminal-group functionalized groups. The biological activity of the drug is ensured through the terminal-group functionalized groups; and the periphery of the peptide dentritic macromolecular drug can be grafted with a lot of terminal-group functionalized groups, so that the biological effect of the terminal-group functionalized groups is effectively amplified by the amplification effect of dendritic macromolecules. The drug has an accurate molecular structure and abundant surface functional groups, is good in water solubility, and also has the biological characteristics of being similar to globulin, easy to be taken in by cells and the like; the biological effect of the peptide dentritic macromolecules is enriched; and the development of peptide drugs is promoted. The preparation method is simple in technology; and the structure of the peptide dentritic macromolecular drug is accurately controlled by controlling preparation of various raw materials.

The present invention relates to the field of high oil-absorbing resin preparation, and discloses a preparation method of an embedded immobilized microbial ball. The method comprises the steps of: (1) preparation of the immobilized microbial particles; (2) preparation of an acrylate copolymer emulsion; and (3) preparation of the embedded immobilized microbial ball. The present invention also discloses a preparation apparatus of the embedded immobilized microbial ball. The apparatus includes an extrusion section, an insulation transport section and a moulding section. The extrusion section comprises an extrusion sections housing, an advancing screw and a rotary motor; the insulation transport section includes a tubular type conveying channel and a heater; and the moulding section comprises a moulding section housing and a pair of reverse gears provided with hemispherical grooves. The embedded immobilized microbial ball prepared by the present invention has high oil suction rate and large oil absorption capacity, and can degrade the adsorbed oil; and microbes have good stability and long survival time. At the same time, the preparation apparatus of the present invention requires mild conditions in the preparation process, protects the survival rate of the microbes to the maximum; and the prepared product has high dimensional stability.

A preparation method for an immobilized microbe oil-spill repairing agent is characterized by comprising the following steps: preparing peanut shell-based active carbon; mixing the peanut shell-based active carbon with a seed bacteria liquid to performing adsorption until adsorption is saturated, so as to form a bacteria suspension; adding a sterilized sodium alginate solution with a temperature of 30-40 DEG C into the above bacteria suspension, uniformly mixing, injecting into a CaCl2 solution with a certain concentration by employing an injector, dispersing into balls and performing crosslinking for 12-24 h, so as to obtain immobilized microbe microballoons; and finally flushing the immobilized microbe microballoons with normal saline for 2-4 times to obtain a finished product. According to the preparation method, the biology-based active carbon modified peanut shell is added into a sodium alginate-calcium chloride embedded immobilized carrier for the first time, the mechanical strength and the mass transfer property of the agent are improved, the activity and the degradation efficiency of microbes are improved; also the cost is low, the technology is simple and easy to operate, the reaction conditions are mild, microbes of the prepared repairing agent is not easy to leak, and the prepared repairing agent is good in stability and reusability, has relatively high microbe activity and cell capacity, and has petroleum hydrocarbon degradation rate of 75-92%.

The invention provides a multi-view stereo image shooting and playback system which uses a single lens to ensure that no ghost can appear on the focal plane image. In the system, the lens aperture is designed to N-numbered fixed sub-apertures or adjustable sub-apertures distributed on the same surface, wherein the fixed sub-apertures can be turned on or off independently; the adjustable sub-apertures can be turned on or off independently and used to adjust the effective clear aperture of the light-passing surface; a system circuit controls each sub-aperture to shoot N parallax image sequences, selects any two image sequences to be used as the parallax image sequence of the binocular stereo television system, adjusts the effective clear aperture of each sub-aperture to adjust the depth of field of each parallax image, selects any one parallax image pair, uses the position parameter and lens parameter of the corresponding aperture and the position parameter of an shot object on the image to calculate the spatial position and motion state of the shot object relatively to the lens, and selects a plurality of sub-apertures shot by any two to N-numbered parallax images to obtain a multi-view stereo image in one direction or any direction.

Relating to the high oil-absorption resin preparation field, the invention discloses a preparation method for a composite high oil-absorption resin. The method includes: (1) preparation of immobilized microbial microspheres: mixing modified mussel shell powder with a seed bacterial liquid, adding a sodium alginate solution into a bacteria adsorbing modified mussel shell powder solution, then injecting the mixed solution into a calcium chloride solution and conducting dispersion into balls, and conducting crosslinking to obtain immobilized microbial microspheres; (2) preparation of an acrylate copolymer emulsion: adding a methylacrylate monomer, styrene, an initiator and an emulsifier into water and conducting stirring emulsification; adding a crosslinking agent and a pore making agent into the emulsion to carry out reaction so as to obtain an acrylate copolymer emulsion; and (3) preparation of composite high oil-absorption resin: adding immobilized microbial microspheres, a coupling agent and cellulose into the acrylate copolymer emulsion, conducting stirring and then performing vacuum drying, thus obtaining the composite high oil-absorption resin. The composite high oil-absorption resin prepared by the method provided by the invention has fast oil absorption speed and large oil absorption capacity, and can carry out microbial degradation on oil.

The invention relates to a preparation method for an oral protein immune carrier, and belongs to the field of medicines. A single template agent is utilized at a room temperature, a mesoporous silica material is synthesized by adopting a sol-gel method. Mesoporous silica particles loaded with a model drug are prepared by adopting bovine serum albumin (BSA) as the model drug and mesoporous silica as a carrier; and the drug loading capacity is 20-21%. Chitosan (CS) is adsorbed on the surface of the mesoporous silica through the electrostatic interaction, so that the biological adhesiveness of the carrier is improved, and the medicine can be effectively prevented from being damaged by a gastrointestinal tract environment. In addition, positively charged chitosan mesoporous silica drug-loaded composite particles are more easily ingested by cells to induce body immunoreaction.

A preparation method for an immobilized microbe oil-spill repairing agent is characterized by comprising the following steps: preparing corncob-based active carbon; mixing the corncob-based active carbon with a seed bacteria liquid to performing adsorption until adsorption is saturated, so as to form a bacteria suspension; adding a sterilized sodium alginate solution with a temperature of 30-40 DEG C into the above bacteria suspension, uniformly mixing, injecting into a CaCl2 solution with a certain concentration by employing an injector, dispersing into balls and performing crosslinking for 12-24 h, so as to obtain immobilized microbe microballoons; and finally flushing the immobilized microbe microballoons with normal saline for 2-4 times to obtain a finished product. According to the preparation method, the biology-based active carbon modified corncob is added into a sodium alginate-calcium chloride embedded immobilized carrier for the first time, the mechanical strength and the mass transfer property of the agent are improved, the activity and the degradation efficiency of microbes are improved; also the cost is low, the technology is simple and easy to operate, the reaction conditions are mild, microbes of the prepared repairing agent is not easy to leak, and the prepared repairing agent is good in stability and reusability, has relatively high microbe activity and cell capacity, and has petroleum hydrocarbon degradation rate of 78-88%.

The invention belongs to the field of medicinal materials and provides a pH-sensitive phospholipid medicinal material. A structural formula of the material is as show in the specification, wherein R1 is -CnH(2n+1) or -CnH2n, n ranges from 11 to 17; R2 is shown in the specification, wherein a is equal to 0, 1, 2, b is equal to 0, 1, 2. A preparation method for the pH-sensitive phospholipid medicinal material comprises the following steps: (1), carrying out amidation reaction on phosphatidyl ethanolamine and lysine with a protective group; (2), modifying phospholipid by virtue of the lysine with the protective group to remove the protective group for reaction; and (3), carrying out amidation reaction on lysine-modified phospholipid and acid anhydride. The medicinal material has good pH sensitivity and charge reversal capacity; and a medicine-carrying lipidosome prepared by use of the medicinal material can be gathered in a targeted manner in a tumor tissue, so that toxic and side effect of medicines on a normal tissue can be reduced.

The invention relates to a cross-linked mitochondrial targeting doxorubicin liposome. The cross-linked mitochondrial targeting doxorubicin liposome is composed of doxorubicin hydrochloride, phospholipid, cholesterol and a cross-linkable mitochondrial targeting pegylated phospholipid medicinal material, a mass ratio of doxorubicin hydrochloride to the phospholipid is 1:(5-20), a molar ratio of the phospholipid to cholesterol to the cross-linkable mitochondrial targeting pegylated phospholipid medicinal material is (50-90):(2-47):(3-8), the structural formula of the cross-linkable mitochondrial targeting pegylated phospholipid medicinal material is shown in the specification, and n in the structural formula is 10, 12, 14 or 16. The invention also provides a preparation method of the liposome. The cross-linked mitochondrial targeting doxorubicin liposome has the advantages of mitochondrial targeting, large absorbed quantity of tumor cells, and high safety.

The invention discloses an orthoester 5-fluorouracil prodrug molecule. The orthoester 5-fluorouracil prodrug molecule is N-5-fluorouracil1-ethyl-2-carbonalkoxy-(1,3) dioxolane-4-methylformamide havinga structure as shown in formula (I) described in the specification, wherein n=2-32 and m=n+2. The invention further discloses a preparation method of the abovementioned prodrug molecule and a nanoparticle prepared therefrom and an application thereof. The orthoester 5-fluorouracil prodrug molecule, the preparation method and the nanoparticle and the application thereof have the advantages that the nanoparticle prepared by the orthoester 5-fluorouracil prodrug molecule not only has the advantages of a small molecule prodrug but also is endowed with the advantage of a nano drug delivery system(that is a drug carrier), the prodrug nanoparticle not only has excellent acid degradation property and reduced tumor cytotoxicity and realizes passive targeting enrichment of a drug in a tumor, the nanoparticle has high drug loading capacity because the drug is used as a main part of the carrier, and the nanoparticle is capable of loading other antitumor drugs and achieves the effect of cooperatively treating the tumor and thus has good application prospects in the field of tumor treatment.

The invention provides an ecological restoration method for a black and odorous river channel, and belongs to the technical field of sewage treatment. According to the method, ecological restoration is carried out on the black and odorous river channel from five aspects of source control and sewage interception, bottom mud treatment, water body purification, ecological restoration and maintenance management, and the method is high in operability, thorough in treatment and high in treatment efficiency; through reconstruction of a riverway ecological system, the self-cleaning capacity of the water body is gradually restored, the peculiar smell and chroma of the black and odorous water body are gradually eliminated, finally ecological balance of the water body is achieved, the water quality is improved, the water body ecological system can be healthily and stably developed for a long time, and good environment-friendly and ecological functions are achieved.

The invention relates to a self-assembled nucleic acid nanotube preparation as well as a preparation method and application thereof. The preparation comprises mTOR siRNA as shown in a sequence SEQ ID NO: 1, L as shown in sequence SEQ ID NO: 2, M as shown in sequence SEQ ID NO: 3, S as shown in sequence SEQ ID NO: 4, and S' as shown in sequence SEQ ID NO: 5; nucleic acid in which single-strand nucleic acid molecular bases supplement each other and are paired is crosslinked into a tubular nucleic acid nanotube preparation. The preparation enables double coiling of siRNA and is self-assembled into a nanotube system, so that siRNA is difficultly degraded by nuclease, and a compound nanotube structure can be generated; therefore, the advantage that nanoparticles are easily absorbed by cells is brought into full play, and the transfection efficiency of cells can be obviously improved; the siRNA can stably enter the cell structure, the original biological activity can be remained, the autophagy and cell proliferation can be adjusted and controlled, the abnormal growth of pulmonary arterial smooth muscle cells can be effectively inhibited, and the self-assembled nucleic acid nanotube preparation can be applied to preparation of medicines for treating pulmonary hypertension.

The invention discloses a hydrogen peroxide responsive ratio meter nanoprobe and its use. The nanoprobe comprises a hydrogen peroxide-responsive fluorescent molecule, a hydrogen peroxide-inert fluorescent molecule and a polymer with good biocompatibility. The invention also discloses a use of the hydrogen peroxide responsive ratio meter nanoprobe in preparation of a detection agent of circulatingtumor cells in peripheral blood of malignant solid tumors. The ratio meter nanoprobe has good water solubility, can be easily taken, has low cytotoxicity and can be used for quantitative imaging of hydrogen peroxide in circulating tumor cells. The ratio meter nanoprobe has excellent fluorescence properties, has good sensitivity and specificity to hydrogen peroxide and can detect difference of levels of hydrogen peroxide in malignant solid tumor cells and difference of intracellular intake amounts.

The invention discloses a magnetic composite nano material and a preparation method and application thereof. The magnetic composite nano material comprises modified magnetic nano particles and a modified macromolecular layer located on the outer surfaces of the modified magnetic nano particles, wherein the modified macromolecular layer comprises macromolecules and polymers connected with the macromolecules through pH response groups, and the response pH value of the pH response groups is smaller than 6.8. The magnetic composite nano material exists in a cluster form before reaching a tumor part, and due to the large particle size, the magnetic composite nano material is not likely to be rapidly removed by kidney metabolism; after the magnetic composite nano material reaches the tumor part,an assembly (the magnetic composite nano material) is gradually dispersed under the tumor subacid condition, the magnetic composite nano material exists in the tumor part in a small-particle-size magnetic nano particle form, and therefore the penetration depth of tumor tissue is increased; and due to falling of the surface modification polymers, surface positive charges are increased, and the nano particles are more easily taken by cells. Therefore, the pH response type magnetic composite nano material cluster enhances the MRI imaging contrast effect and improves the tissue penetration.

A magnetic nanoball carrying cisplatin is disclosed, which can be used as the medicine carrier to provide magnetic targetability. Its preparing process includes such steps as preparing the carboxypolyose modified Fe3O4 nanopartieles by chemical codeposition method under existence of carboxypolyose, and coordination between the free carboxy in carboxypolyose on the surface of Fe3O4 nanoparticle and Pt atoms for coupling the cisplatin with said nanoparticle. It can be used for the controlled slow-release medicine applying system.