39 results about "Miscellaneous antineoplastic" patented technology

The invention discloses a beta-carboline derivative containing hydroximic acid as well as a preparation method and a medical application thereof. The product has the structure as shown in the general formula I. The compound can be combined with other antitumor drugs such as alkylating agents, antimetabolites, topoisomerase inhibitors, mitotic inhibitors and DNA intercalating agents and additionally can be combined with radiotherapy. The invention also discloses a pharmaceutical composition containing the compound with the general formula I as well as medical application thereof, particularly application of preparation of antitumor medicines, Alzheimer disease medicines and Parkinson disease medicines. The other antitumor medicines or radiotherapy can be administrated with the compound at the same time or in different times. The combination therapy can generate the synergistic effect, so that the treatment effect is improved.

A method is disclosed for encapsulating plasmids, oligonucleotides or negatively-charged drugs into liposomes having a different lipid composition between their inner and outer membrane bilayers and able to reach primary tumors and their metastases after intravenous injection to animals and humans. The formulation method includes complex formation between DNA with cationic lipid molecules and fusogenic / NLS peptide conjugates composed of a hydrophobic chain of about 10-20 amino acids and also containing four or more histidine residues or NLS at their one end. The encapsulated molecules display therapeutic efficacy in eradicating a variety of solid human tumors including but not limited to breast carcinoma and prostate carcinoma. Combination of the plasmids, oligonucleotides or negatively-charged drugs with other anti-neoplastic drugs (the positively-charged cis-platin, doxorubicin) encapsulated into liposomes are of therapeutic value. Also of therapeutic value in cancer eradication are combinations of encapsulated the plasmids, oligonucleotides or negatively-charged drugs with HSV-tk plus encapsulated ganciclovir.

A method for encapsulating cisplatin and other positively-charged drugs into liposomes having a different lipid composition between their inner and outer membrane bilayers is disclosed. The liposomes are able to reach primary tumors and their metastases after intravenous injection to animals and humans. The encapsulated cisplatin has a high therapeutic efficacy in eradicating a variety of solid human tumors including but not limited to breast carcinoma and prostate carcinoma. Combination of the encapsulated cisplatin with encapsulated doxorubicin or with other antineoplastic drugs are claimed to be of therapeutic value. Also of therapeutic value in cancer eradication are claimed to be combinations of encapsulated cisplatin with a number of anticancer genes including but not limited to p53, IL-2, IL-12, angiostatin, and oncostatin encapsulated into liposomes as well as combinations of encapsulated cisplatin with HSV-tk plus encapsulated ganciclovir.

The present invention provides a composition for treating cancers, which comprises (a) pharmaceutically acceptable carriers and (b) an effective amount of an aqueous or aqueous organic solvent extract of a crude preparation comprising Semen Trigonellae, Astragali Radix, Glehniae Radix, and Asparagi Radix. The preferred composition further comprises the extract of other anti-tumor medicinal materials, such as Fructus Ligustri Lucidi, or Herba Selaginellae Doederleinii. The present invention also provides the preparation method and use of the composition in treating cancers, especially lung cancers.

The invention discloses a benzyl cyclohexenone derivative and a preparation method and medical application thereof. The benzyl cyclohexenone derivative is a compound in a general formula I. The compound can be individually prepared into a preparation or can be combined with one or more pharmaceutically acceptable carriers to prepare the preparation for administration. The compound can be combined with other antitumor drugs for application, and can also be combined with radiotherapies for application. These antitumor drugs or radiotherapies and the compound disclosed by the invention can be given at the same time or different times. These combination therapies can generate a synergistic effect to improve the treatment effect.

The invention provides benzothiazine and benzothiadiazine compounds as well as analogues, pharmaceutically acceptable salts, stereoisomers and solvates of the compounds having a structure shown in a general formula a. Repeated experiments prove that the compounds have an inhibition action on PI3Kdelta, wherein most compounds selectively have a remarkableinhibition action on PI3Kdelta, the compounds can be applied to preparation of anti-inflammation and anti-tumor drugs, the range of involved tumor and inflammatory diseases is wide, and the compounds particularly have a better inhibition effect on FL (follicular B-cell non-Hodgkin lymphoma) relapsing in a treatment period, recurrent CLL (chronic lymphocytic leukemia) and recurrent SLL (small lymphocytic lymphoma). Prepared drugs can be combined with other anti-tumor drugs for use and have an obvious effect, and novel treatment drugs are provided for clinically resisting tumors and inflammation diseases.

A method for screening natural active component in multiple target point anti-tumor traditional Chinese medicine, especially comprises: extracting a receptor enrichment region containing EGFR, TNFR, Fas from a human breast cancer MCF-7 cell strain, connected to a silica gel stantionary phase to form a separated silica gel column or a chromatographic column, realizing highly efficient screening of the active component in the multiple target anti-tumor traditional Chinese medicine, and changing the current situation of single target screening of the traditional Chinese medicine active component. Not only the screening method provides example for highly efficinet screening of the EGFR, TNFR and FAS inhibitors, but also the design thought provides mirror and reference value for the active component screening of other anti-tumor medicine, and it is ensured that the design thought has wide application space in the active component screening of the traditional Chinese medicine. The invention discloses a preparation method.

The invention discloses an orthoester 5-fluorouracil prodrug molecule. The orthoester 5-fluorouracil prodrug molecule is N-5-fluorouracil1-ethyl-2-carbonalkoxy-(1,3) dioxolane-4-methylformamide havinga structure as shown in formula (I) described in the specification, wherein n=2-32 and m=n+2. The invention further discloses a preparation method of the abovementioned prodrug molecule and a nanoparticle prepared therefrom and an application thereof. The orthoester 5-fluorouracil prodrug molecule, the preparation method and the nanoparticle and the application thereof have the advantages that the nanoparticle prepared by the orthoester 5-fluorouracil prodrug molecule not only has the advantages of a small molecule prodrug but also is endowed with the advantage of a nano drug delivery system(that is a drug carrier), the prodrug nanoparticle not only has excellent acid degradation property and reduced tumor cytotoxicity and realizes passive targeting enrichment of a drug in a tumor, the nanoparticle has high drug loading capacity because the drug is used as a main part of the carrier, and the nanoparticle is capable of loading other antitumor drugs and achieves the effect of cooperatively treating the tumor and thus has good application prospects in the field of tumor treatment.

The invention relates to Artemisinin derivatives of general formula (I)wherein A and B are as defined in the specification. Compounds (I) have proved able to inhibit cell proliferation, in particular of uveal melanoma cells, and can therefore be used, either alone or in association with other antitumoral drugs, for the preparation of medicaments intended for the treatment of malignant melanoma.

The invention discloses a human colorectal cancer cetuximab drug-resistant cell line, and belongs to the field of biomedical technology. The human colorectal cancer cetuximab drug-resistant cell linehas the advantages that a human colorectal cancer cell line NCI-H508 is treated by the cetuximab of different concentration, and the drug concentration for survival of 50% of cells is used as the initial concentration to treat the cells for a long time, until the cell NCI-H508 can normally grow under the concentration; the cell NCI-H508 is continued to treat for a long time by a gradual increasingmethod, the treatment duration is six months, and finally the human colorectal cancer cetuximab drug-resistant cell line NCI-H508 / C225 which can quickly grow under the treatment function of the cetuximab can be finally obtained; the human colorectal cancer cetuximab drug-resistant cell line can be used for analyzing the phenotypic change of morphology and biology after drug resistance of human colorectal cancer cetuximab, studying the molecule mechanism of the human colorectal cancer cetuximab drug resistance and the reversing drug resistance method, screening other anti-tumor drugs, findingthe tumor drug-resistant markers, and screening and evaluating the novel antitumor drugs and the like, and the scientific and research value and the production and application value are higher.

The invention provides a formulation of one or more antineoplastic drugs encapsulated in liposomes including at least a lipid fraction in addition to the antineoplastic drug, wherein the composition is stable in an aqueous solution at room temperature.

The invention discloses an artabotrys pilosus total alkaloid extract, which is prepared by the following steps: taking dry powder of artabotrys pilosus branches and leaves, carrying out cold soaking extraction with acid water, and mixing acid water extract liquid; filtering, and alkalifying with alkaline water; adding ethyl acetate, extracting, recovering the ethyl acetate in vacuum to obtain an ethyl acetate extract part, namely the total alkaloid part of the artabotrys pilosus branches and leaves, wherein the part mainly comprises 12 alkaloids, including four aporphinoid alkaloids, two benzylisoquinoline alkaloids, two original aporphinoid alkaloids, two morphinane alkaloids and two protoberberine alkaloids. The prepared total alkaloid extract is high in yield, simple in technological process, low in cost and suitable for relatively large-scale preparation, has good antitumor activity, and can be applied to treatment of various tumorous diseases independently or together with other anti-tumor medicines to treat various tumorous diseases.

The present invention discloses a triple-negative breast cancer cisplatin drug-resistance cell line, which is named human triple-negative breast cancer drug-resistance cell line MDA-MB-231 / DDP and has the preservation number of CGMCC No.10406. The present invention further discloses a preparation method of the triple-negative breast cancer cisplatin drug-resistance cell line, and applications of the triple-negative breast cancer cisplatin drug-resistance cell line in preparation of breast cancer drug-resistance reversal drugs. According to the present invention, the triple-negative breast cancer cisplatin drug-resistance cell line can be used for analyzing the morphology and biological phenotype change of the triple-negative breast cancer cells after DDP resistance, researching the molecular mechanism of the tumor on DDP resistance, researching the tumor drug-resistance reversal method, screening other antitumor drugs, detecting tumor drug-resistance markers, screening and evaluating novel antitumor drugs and the like, and has high research values and high production application values; and experiment results verify that the drug-resistance index of the triple-negative breast cancer cisplatin drug-resistance cell line MDA-MB-231 / DDP is 11, and the triple-negative breast cancer cisplatin drug-resistance cell line MDA-MB-231 / DDP has high drug resistance and can be used for preparing breast cancer drug-resistance reversal drugs.

The present invention discloses mineral enriched ginger juice milk curd health-care drink and a preparation method thereof, and relates to the technical field of food processing. The drink is mainly prepared from the following raw materials: pure milk, fresh gingers, radix puerariae powder, walnut powder, mung bean soup, fresh kalimeris indica, black tea soaking liquid, oryza sativa L. var. glutinosa root hair, figs, longan, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, etc. The three ingredients of the brown sugar, radix puerariae and walnut kernels are added into the ginger juice milk curd health-care drink, the addition of the brown sugar helps to reduce the spicy taste of the fresh gingers, and the fresh gingers and brown sugar are combined to also have functions of dispelling cold and warming stomach. The radix puerariae has functions of preventing cancers, beautifying features, and preventing tumors. Besides, the fresh gingers contain geraniol compounds and have the effect of enhancing the effectiveness of other anti-tumor drugs, and the combination of the fresh gingers and radix puerariae is good in anti-tumor effects. The walnut kernels are rich in proteins, unsaturated fatty acids, phosphorus, calcium, etc., and have functions of supplementing qi and nourishing blood, and warming lungs and relieving asthma.

The invention provides an anti-tumor pharmaceutical composition and combination drug. The drug is formed by daphnetin and an anti-tumor drug according to a certain ratio. Experiment results prove thatafter the daphnetin is used with other anti-tumor drugs, a remarkable anti-tumor effect is achieved.

The invention provides a composite probiotic preparation for targeting treatment on tumor and a preparation method of the composite probiotic preparation. By adopting the technical scheme, on the basis of physiological actions of various probiotics and synergic relationships of the probiotics, bifidobacterium adolescentis, lactobacillus crispatus, lactobacillus jensenii, lactobacillus vaginalis and lactobacillus johnsonii are adopted as preparation main bodies, on the basis, a compounding scheme is designed from angles of amount proportioning, numbers of viable organisms, and the like, and aneffective preparation method is provided. By adopting the preparation, targeting treatment on tumor can be achieved in an oral taking mode, and meanwhile the preparation can have synergetic effects with other anti-tumor medicines to promote anti-tumor effects of the preparation. The preparation is safe and non-toxic, free of conspicuous side effect, free of limits of tumor sizes and types, and good in quantitative treatment effect on various types of tumor.

The present invention discloses a milk curd health drink with ginger juice and helping to expel toxins and beautify, and a preparation method thereof. The invention relates to the technical field of food processing. The health drink is mainly prepared from pure milk, ginger, radix puerariae powder, walnut powder, pear juice, milk tea, passion fruits, fruits of cerasus humilis, lotus petiole, wild chrysanthemum, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, etc. Three ingredients of the brown sugar, radix puerariae and walnut kernels are added in the milk curd health drink with ginger juice provided by the invention. The adding of the brown sugar can not only help to reduce the spicy flavor of the ginger, but also has cold dispelling and stomach warming effects through the combined use of the ginger and the brown sugar; the radix puerariae has cancer preventing, beautifying, anti-cancer and anti-tumor effects, while the ginger contains a compound called geraniol which enhances the effects of other anti-tumor drugs, and the combined use of the ginger and the radix puerariae can have better anti-tumor effects; the walnut kernels are rich in protein, unsaturated fatty acid, phosphorus, calcium, etc., and have the effects of invigorating vital energy, nourishing blood, warming lungs and relieving asthma.

The present invention discloses a milk curd health drink with ginger juice and a preparation method thereof, and relates to the technical field of food processing. The health drink is mainly prepared from pure milk, ginger, radix puerariae powder, walnut powder, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, etc. Three ingredients of the brown sugar, radix puerariae and walnut kernels are added in the milk curd health drink with ginger juice provided by the invention. The adding of the brown sugar can not only help to reduce the spicy flavor of the ginger, but also has cold dispelling and stomach warming effects through the combined use of the ginger and the brown sugar; the radix puerariae has cancer preventing, beautifying, anti-cancer and anti-tumor effects, while the ginger contains a compound called geraniol which enhances the effects of other anti-tumor drugs, and the combined use of the ginger and the radix puerariae can have better anti-tumor effects; the walnut kernels are rich in protein, unsaturated fatty acid, phosphorus, calcium, etc., and has the effects of invigorating vital energy, nourishing blood, reinforcing the kidney to strengthen essence, warming lungs and relieving asthma.

Disclosed is a method for predicting clinical response of a cancer patient to treatment with an immune checkpoint inhibitor, or a combination of two or more thereof, or with a combination of an immune checkpoint inhibitor and other antitumor drugs, by introducing bispecific T cell engager (BiTE) into the platform of lymphocytes containing T cells in vitro, which are cultured on feeder cells or in Matrigel®.

The invention discloses a vitamin-enriched ginger juice curd health-care beverage and a preparation method thereof, and relates to the technical filed of food processing. The vitamin-enriched ginger juice curd health-care beverage is mainly prepared from the following raw materials: pure milk, fresh gingers, kudzuvine root powder, walnut kernel powder, coconut juice, red beans juice, peanut kernel powder, dried persimmon powder, athyrium multidentatum ching, rice vinegar, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, and so on. The three ingredient, namely the brown sugar, the kudzuvine root powder and the walnut kernel powder, are added into the ginger juice curd health-care beverage disclosed by the invention. The addition of the brown sugar is beneficial for reducing the pungent taste of the fresh gingers; the combination of the fresh gingers and the brown sugar has the effects of dispelling cold and warming the stomach; the kudzuvine roots have the effects of preventing and resisting cancer, beautifying, and resisting tumors; the fresh gingers contain a geraniol compound which has the effect of enhancing the functions of other anti-tumor drugs; the combined use of the fresh gingers and the kudzuvine roots has better anti-tumor effects; the walnut kernels are rich in protein, unsaturated fatty acids, phosphorus, calcium, and the like; and the walnut kernels have the effects of tonifying Qi, nourishing the blood, warming the lung, and stopping asthma.

The invention relates to a belinostat structural analogue with the histone deacetylase inhibiting effect and an application of the belinostat structural analogue. The active component of the belinostat structural analogue at least includes a compound of the general formula of the belinostat structural analogue and pharmaceutical salt, aquo-complex, predrugs or metabolite products formed by any forms of metabolism. The belinostat structural analogue has the remarkable histone deacetylase inhibiting effect and antitumor activity, and the compound is suggested to have potential applications in combination with preparation of pharmaceutical drugs related to histone deacetylase relevant diseases, preparation of antitumor drugs and other antitumor drugs or radiation therapy for tumor treatment.

The invention discloses a dietary-fiber-enriched ginger juice curd health-care beverage and a preparation method thereof, and relates to the technical filed of food processing. The dietary-fiber-enriched ginger juice curd health-care beverage is mainly prepared from the following raw materials: pure milk, fresh gingers, kudzuvine root powder, walnut kernel powder, chicken livers, pepper sauce, eel meat, malacophyllus umbilicus pulp, wheat fiber powder, plum flesh paste, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, and so on. The three ingredients, namely the brown sugar, the kudzuvine root powder and the walnut kernel powder, are added into the ginger juice curd health-care beverage disclosed by the invention. The addition of the brown sugar is beneficial for reducing the pungent taste of the fresh gingers; the combination of the fresh gingers and the brown sugar has the effects of dispelling cold and warming the stomach; the kudzuvine roots have the effects of preventing and resisting cancer, beautifying, and resisting tumors; the fresh gingers contain a geraniol compound which has the effect of enhancing the functions of other anti-tumor drugs; the combined use of the fresh gingers and the kudzuvine roots has better anti-tumor effects; the walnut kernels are rich in protein, unsaturated fatty acids, phosphorus, calcium, and the like; and the walnut kernels have the effects of tonifying Qi, nourishing the blood, warming the lung, and stopping asthma.

The present invention discloses a milk curd health drink with ginger juice and rich nutrients and a preparation method thereof, and relates to the technical field of food processing. The health drink is mainly prepared from pure milk, ginger, radix puerariae powder, walnut powder, muskmelon juice, fish sauce, black bone chicken soup, banana powder, peanut milk, tartarian buckwheat pollen, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, etc. Three ingredients of the brown sugar, radix puerariae and walnut kernels are added in the milk curd health drink with ginger juice provided by the invention. The adding of the brown sugar can not only help to reduce the spicy flavor of the ginger, but also has cold dispelling and stomach warming effects through the combined use of the ginger and the brown sugar; the radix puerariae has cancer preventing, beautifying, anti-cancer and anti-tumor effects, while the ginger contains a compound called geraniol which enhances the effects of other anti-tumor drugs, and the combined use of the ginger and the radix puerariae can have better anti-tumor effects; the walnut kernels are rich in protein, unsaturated fatty acid, phosphorus, calcium, etc., and have the effects of invigorating vital energy, nourishing blood, warming lungs and relieving asthma.

The invention discloses an osmanthus fragrans ginger juice curd health-care drink and a making method thereof and relates to the technical field of food processing. The drink is mainly made from pure milk, fresh ginger, radix pueraria powder, walnut powder, green tangerine peel, pearl powder, goose meat, soybean milk, rhizoma chuanxiong, osmanthus fragrans petals, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar and others. The three kinds of components, namely the brown sugar, the radix pueraria and the walnut nuts, are added, the added brown sugar can reduce the spicy flavor of the fresh ginger, and the effect of dispelling cold for warming the stomach is achieved through cooperation of the fresh ginger and the brown sugar; the radix pueraria has the effects of preventing cancers, resisting the cancers, achieving beautifying and resisting tumors, the fresh ginger contains a geraniol compound, and therefore the effect of enhancing the function of other anti-tumor medicine is achieved; through cooperated usage of the fresh ginger and radix pueraria, the anti-tumor effect is good; the walnut kernels contain rich protein, unsaturated fatty acid, phosphorus, calcium and others, and have the effects of tonifying qi, nourishing blood and warming the lungs for stopping asthma.

The invention relates to preparation and application of an amphiphilic ursolic acid-polysaccharide coupled substance with antitumor activity. The ursolic acid is chemically modified to substitute C3 site carboxyl group with amino group, the generated aminated ursolic acid is chemically coupled to a polysaccharide framework to form the amphiphilic ursolic acid-polysaccharide coupled substance, and the amphiphilic ursolic acid-polysaccharide coupled substance can be self-assembled into a nano micelle in water. The method is characterized in that the antitumor activity of the chemically modified ursolic acid is obviously enhanced; the hydrophobic inner core formed by the hydrophobic group can physically wrap the antineoplastic drug to obviously improve the solubility of the antineoplastic drug; and the antineoplastic drug which is physically wrapped by the chemically coupled ursolic acid can implement combined chemotherapy, has higher antitumor activity, has the combined synergetic action, and lowers the toxicity. The preparation method is simple and easy to operate, has the advantage of higher yield, and can easily implement industrialization.

The present invention discloses cancer preventing ginger juice milk curd health-care drink and preparation method thereof, and relates to the technical field of food processing. The drink is mainly prepared from the following raw materials: pure milk, fresh gingers, radix puerariae powder, walnut powder, Chinese date honey, purple sweet potatoes, bamboo leaf green wine, rice wine, lagenaria siceraria, fish brain, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, etc. The three ingredients of the brown sugar, radix puerariae and walnut kernels are added into the ginger juice milk curd health-care drink, the addition of the brown sugar helps to reduce the spicy taste of the fresh gingers, and the fresh gingers and brown sugar are combined to also have functions of dispelling cold and warming stomach. The radix puerariae has functions of preventing cancers, beautifying features, and preventing tumors. Besides, the fresh gingers contain geraniol compounds and have the effect of enhancing the effectiveness of other anti-tumor drugs, and the combination of the fresh gingers and radix puerariae is good in anti-tumor effects. The walnut kernels are rich in proteins, unsaturated fatty acids, phosphorus, calcium, etc., and have functions of supplementing qi and nourishing blood, and warming lungs and relieving asthma.

The present invention discloses lotus leaf ginger juice milk curd health-care drink and a preparation method thereof, and relates to the technical field of food processing. The drink is mainly prepared from the following raw materials: pure milk, fresh gingers, radix puerariae powder, walnut powder, non-dairy creamer, lotus leaves, sorghum rice flour, mashed potatoes, linseed oil residues, brewer's grains, papain, carrageenan, xanthan gum, locust bean gum, white granulated sugar, brown sugar, etc. The three ingredients of the brown sugar, radix puerariae and walnut kernels are added into the ginger juice milk curd health-care drink, the addition of the brown sugar helps to reduce the spicy taste of the fresh gingers, and the fresh gingers and brown sugar are combined to also have functions of dispelling cold and warming stomach. The radix puerariae has functions of preventing cancers, beautifying features, and preventing tumors. Besides, the fresh gingers contain geraniol compounds and have the effect of enhancing the effectiveness of other anti-tumor drugs, and the combination of the fresh gingers and radix puerariae is good in anti-tumor effects. The walnut kernels are rich in proteins, unsaturated fatty acids, phosphorus, calcium, etc., and have functions of supplementing qi and nourishing blood, and warming lungs and relieving asthma.

The invention discloses a ginger juice curd health-care beverage for assisting in resisting ageing and a preparation method of the ginger juice curd health-care beverage, and relates to the technical field of food processing. The ginger juice curd health-care beverage is mainly prepared from pure milk, fresh ginger, radix puerariae powder, walnut powder, Pu'er tea, lobster shells, pulp of watermelons, peanut red coats, jellied pork skin, durian powder, papain, carrageenin, xanthan gum, locust bean gum, white granulated sugar, brown sugar and the like. Three components including the brown sugar, radix puerariae and walnut kernels are added to the ginger juice curd health-care beverage disclosed by the invention, the added brown sugar not only contributes to reduction of hot taste of the fresh ginger, and the fresh ginger and the brown sugar are matched, so that the effects of dispelling cold and warming the stomach can also be achieved; the radix puerariae has the effects of preventing cancer, resisting cancer, beautifying the features and resisting tumors; the fresh ginger contains a geraniol compound which has the effect of strengthening efficacies of other antitumor drugs, and the fresh ginger and the radix puerariae are matched for use, so that the antitumor effect is good; and the walnut kernels are rich in contents of protein, unsaturated fatty acid, phosphorus, calcium and the like, and have the effects of benefiting qi, nourishing blood, warming the lung and relieving asthma.