4 results about "Tumor cytotoxicity" patented technology

The application discloses a flavonoid compound with tumor cytotoxicity and anti-inflammatory effect, and a preparation method and application thereof, and belongs to the field of phytochemistry. The application discloses a new compound (2', 4', 5, 7-tetrahydroxy-5'-isopentenyl dihydroflavone) obtained through the following process steps: taking medicinal material of Cudrania tricuspidata as raw material, ethanol reflux extraction, ethyl acetate extraction, silica gel column chromatography separation, and preparation type HPLC system preparation. The compound 2', 4', 5, 7-tetrahydroxy-5'-isopentenyl dihydroflavone (formula I) has significant tumor cytotoxic activity on various cancer cells of human body, also has anti-inflammatory and anti-aging activities, and has the application prospect of developing anticancer, anti-inflammatory and / or anti-aging drugs.

The invention discloses a lentinan-gold nanocluster fluorescent probe as well as a preparation method and application thereof, and relates to the technical field of biomedical materials and natural polysaccharide functionalization. Aminated lentinan and glutathione modified gold nanoclusters are used as raw materials, and covalent coupling is performed under mild conditions to obtain the lentinan-gold nanocluster fluorescent probe. Strong acid, strong alkali and high temperature conditions are avoided in the preparation process, and the natural triple helix conformation of the lentinan can be effectively reserved, so that the inherent anti-tumor biological activity of the lentinan is maintained. The prepared fluorescent probe is uniform in particle size, the average size is about 150 nm, and tumor site enrichment can be achieved through the enhanced permeation and retention effect (EPR effect) of tumors. In a tumor microenvironment, the inherent anti-tumor activity of the lentinan and the tumor cell toxicity induced by peroxidase-like activity shown by Au-GSH generate a synergistic effect, and the probe has a stable fluorescence signal and can realize in-vivo tracing and imaging.

The invention relates to the technical field of research and development of tumor photodynamic therapy photosensitizers, photothermal therapy photothermal reagents and sonodynamic therapy sonosensitizers, and provides two bithiazole bridging ligands and preparation methods thereof as well as binuclear metal complexes of the bithiazole bridging ligands as well as preparation methods and application of the binuclear metal complexes. According to the invention, a binuclear ruthenium complex, a binuclear osmium complex and a binuclear iridium complex are respectively designed and invented on the basis of bithiazole bridging ligands bpytztz and piptzpip. The two types of bithiazole bridged binuclear metal complexes have extremely high stability and excellent two-photon absorption characteristics, have excellent tumor cytotoxicity and photothermal conversion capacity under the action of infrared exciting light, can induce cell apoptosis and effectively inhibit growth of tumors in mice. The bithiazole bridged binuclear metal complex provided by the invention is a potential novel infrared photodynamic photosensitizer, a photothermal reagent and a sonodynamic therapy sonosensitizer, and has a wide application prospect in photodynamic therapy, photothermal therapy and sonodynamic therapy of tumors.