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Composite probiotic preparation for targeting treatment on tumor and preparation method of composite probiotic preparation

A tumor targeting and bacterial agent technology, applied in the field of microorganisms, can solve the problems of physical injury, systemic toxicity, weak specificity, etc., and achieve the effect of reducing side effects and promoting anti-tumor effect.

Inactive Publication Date: 2018-06-15
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although traditional cancer treatments such as surgical resection, radiotherapy and chemotherapy are widely used, due to individual differences, such methods are almost ineffective for most patients and cause certain harm to the body, while most anticancer drugs on the market are specific Not strong, causes systemic toxicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A compound probiotic bacterial agent for targeted tumor therapy and a preparation method thereof, comprising Bifidobacterium adolescent, Lactobacillus crispatus, Lactobacillus jansii, vaginal Lactobacillus and Lactobacillus johnsonii; the number of viable bacteria in the compound probiotic bacterial agent is 10 9 pcs / g.

[0026] A preparation method of the above-mentioned composite probiotic bacterial agent, comprising the following steps:

[0027] 1) Bacteria selection and activation: five kinds of probiotics were selected for medium activation;

[0028] 2) Mixing and centrifugation: the bacteria solution obtained in step 1) is mixed according to the volume ratio of 1:1:1:1:1 and then centrifuged to obtain the bacteria;

[0029] 3) Freeze-drying: adding a freeze-dried powder protective agent to the cells obtained in step 2), and freeze-drying in a freeze-drying machine.

[0030] On the basis of the above technical solutions, the following conditions are met:

[003...

Embodiment 2

[0037] A compound probiotic bacterial agent for targeted tumor therapy and a preparation method thereof, comprising Bifidobacterium adolescent, Lactobacillus crispatus, Lactobacillus jansii, vaginal Lactobacillus and Lactobacillus johnsonii; the number of viable bacteria in the compound probiotic bacterial agent is 10 9 pcs / g.

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PUM

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Abstract

The invention provides a composite probiotic preparation for targeting treatment on tumor and a preparation method of the composite probiotic preparation. By adopting the technical scheme, on the basis of physiological actions of various probiotics and synergic relationships of the probiotics, bifidobacterium adolescentis, lactobacillus crispatus, lactobacillus jensenii, lactobacillus vaginalis and lactobacillus johnsonii are adopted as preparation main bodies, on the basis, a compounding scheme is designed from angles of amount proportioning, numbers of viable organisms, and the like, and aneffective preparation method is provided. By adopting the preparation, targeting treatment on tumor can be achieved in an oral taking mode, and meanwhile the preparation can have synergetic effects with other anti-tumor medicines to promote anti-tumor effects of the preparation. The preparation is safe and non-toxic, free of conspicuous side effect, free of limits of tumor sizes and types, and good in quantitative treatment effect on various types of tumor.

Description

technical field [0001] The invention relates to the technical field of microbes, further relates to the physiological application of probiotics and the treatment of tumors, and in particular to a compound probiotic bacterial agent for targeted tumor therapy and a preparation method thereof. Background technique [0002] Probiotics refer to active microorganisms that can coexist with the host and can produce substances that promote the balance of host intestinal microorganisms. They have been used as commercial preparations for more than 1,000 years and are widely used in the fields of bioengineering, industry and agriculture, food safety, and life and health. . So far, the probiotics that scientists have discovered can be roughly divided into three categories, including: lactobacilli, bifidobacteria, and Gram-positive cocci. In addition, some yeasts and enzymes can also be classified as probiotics category. The main functions of probiotics can be summarized as follows: pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20C12N1/04A61K35/747A61K35/745A61P35/00A61P1/00A61P37/04A61P1/14A61P1/12C12R1/225C12R1/01
CPCC12N1/20A61K35/745A61K35/747C12N1/04A61K2300/00
Inventor 陈廷涛辛洪波孟凡景
Owner NANCHANG UNIV
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