Cytolysosome-targeting anticancer cluster and preparation method thereof
A technology targeting cells and lysosomes, applied in the chemical industry, can solve the problems of uncontrollable dosage and poor targeting, and achieve the effect of rich structure types and good stability
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Embodiment 1
[0024] The synthesis of anticancer nanoclusters, the steps are as follows: chloroauric acid and 6-thioguanine are mixed uniformly at room temperature, wherein the molar ratio of chloroauric acid to 6-thioguanine is 1:40, and 1.5 gamma rays are irradiated. Anticancer nanoclusters were obtained after h, in which the radioactive source of gamma ray radiation 60 Co, dose rate 6kGy / h (provided by Beijing Hongyi Sifang Radiation Technology Co., Ltd.). Ultrafiltration was performed with a 3KDa ultrafiltration tube to finally obtain purified anticancer nanoclusters.
Embodiment 2
[0026] The synthesis of anticancer nanoclusters, the steps are as follows: chloroauric acid and 6-thioguanine are mixed uniformly at room temperature, wherein the molar ratio of chloroauric acid to 6-thioguanine is 10:1, and 2.5 gamma rays are irradiated Anticancer nanoclusters were obtained after h, in which the radioactive source of gamma ray radiation 60 Co, dose rate 6kGy / h (provided by Beijing Hongyi Sifang Radiation Technology Co., Ltd.). Ultrafiltration was performed with a 3KDa ultrafiltration tube to finally obtain purified anticancer nanoclusters.
Embodiment 3
[0028] Synthesis of anticancer nanoclusters, the steps are as follows: mix chloroauric acid and 6-thioguanine at room temperature, wherein the molar ratio of chloroauric acid to 6-thioguanine is 1:2, and irradiate with gamma rays for 2h After obtaining anticancer clusters, the radioactive source of γ-ray radiation 60 Co, dose rate 6kGy / h (provided by Beijing Hongyi Sifang Radiation Technology Co., Ltd.). Ultrafiltration was performed with a 3KDa ultrafiltration tube to finally obtain purified anticancer clusters.
[0029] Taking the anticancer cluster prepared in Example 3 as an example to perform related performance tests, wherein:
[0030] figure 1 For the mass spectrogram of anticancer clusters, 2mL of 1.5mmol / L anticancer nanoclusters were purified with a 3KDa ultrafiltration tube, and a high-resolution mass spectrometer (WatersQ-TOFpremier purchased from U.S. WatersQ-TOFpremier in negative ion mode was used) The world company conducts mass spectrometry test), and its m...
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