Ratiometric viscous flare fluorescent probe as well as preparation method and application thereof
A fluorescent probe and ratiometric technology, which is applied in the field of analysis, detection and medical diagnosis, can solve the problems of high specificity and low fluorescence background, and achieve the effects of weak background fluorescence, high cell uptake rate and low cytotoxicity
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[0035] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
[0036] The fluorescent probe of the present invention is a ratio type sticky-flare fluorescent probe for the quantitative detection of telomerase activity for the detection of telomerase activity, and is based on gold nanoparticles (AuNPs) with a diameter of about 13 nm (about 13 ± 5 nm). ) is a carrier, and a high-density DNA double-strand with different fluorescent groups that specifically recognizes telomerase is connected on its surface.
[0037] One DNA single strand in the DNA double strand is FL-R flare long chain, and described FL-R flare long chain is successively fluorescent dye (F 1 ...
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