Magnetic nano-balls carried with cisplatin and its prepn. method

A magnetic nanosphere and nanotechnology, applied in the field of nanometers, can solve the problems of low molecular weight of cisplatin, inability to exert anticancer effect well, and large toxic and side effects

Inactive Publication Date: 2006-06-14
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cisplatin-based chemotherapy still has many problems: ① Cisplatin has a low molecular weight and is transported too quickly in the blood circulation, so it cannot exert its anti-cancer effect well; ② Intravenous administration, systemic chemotherapy, has large toxic and side effects; ③ After long-term chemotherapy, it is easy to lead to drug resistance in the body
Liposomes, polymers, polysaccharides, etc. are currently being studied. These carriers can control the release of drugs, but they do not have targeting

Method used

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  • Magnetic nano-balls carried with cisplatin and its prepn. method
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  • Magnetic nano-balls carried with cisplatin and its prepn. method

Examples

Experimental program
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Effect test

Embodiment 1

[0034] ① Take 9.6g FeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 60% 3 solution, weighing 5g FeSO 4 .7H 2 O, formulated as FeSO with a mass concentration of 20% 4 solution, the two solutions are mixed to form an iron salt mixed solution (ferrous sulfate: the molar ratio of ferric chloride=1:2). The sodium alginate that 20g weight average molecular weight is 20,000 is dissolved in 100ml concentration and is made into sodium alginate ammonia water mixed solution (ammonia water: the mol ratio of ferric chloride is 40: 1, and sodium alginate is to The mass ratio of ferric oxide is 5:1). The iron salt mixed solution and the sodium alginate ammonia mixed solution were mixed under stirring at 800 rpm, and then reacted under stirring for 50 minutes, and the reaction temperature was stabilized at 90°C. ②After the reaction, use a centrifuge to centrifuge the prepared water-based ferroferric oxide magnetic liquid to remove the precipitated large particles, ensure ...

Embodiment 2

[0036] ① Take 9.6 g FeCl 3 .6H 2 O, formulated as FeCl with a mass concentration of 30% 3 solution, weighing 6g FeSO4 .7H 2 O, made into FeSO with a mass concentration of 15% 4 solution, the two solutions were mixed to form a mixed solution of iron salt (the molar ratio of ferrous sulfate: ferric chloride = 1.2:2). Dissolving 16g of potassium alginate with a weight-average molecular weight of 20,000 in 80 ml of concentrated ammonia water with a concentration of 25Wt% is made into a mixed solution of potassium alginate ammonia water (aqueous ammonia: the mol ratio of ferric chloride is 32:1, potassium alginate The mass ratio to ferric tetroxide is 4:1). The mixed solution of iron salt and the mixed solution of potassium alginate and ammonia water were mixed under stirring at 800 rpm, and then reacted under stirring for 50 minutes, and the reaction temperature was stabilized at 90°C. Step 2. and step 3. are the same as in Example 1, and obtain potassium alginate modified na...

Embodiment 3

[0038] ① Take 9.6 g FeCl 3 .6H 2 O, made into FeCl with a mass concentration of 45% 3 solution, weighing 7 g FeSO 4 .7H 2 O, made into FeSO with a mass concentration of 20% 4 solution, the two solutions were mixed to prepare a mixed solution of iron salt (the molar ratio of ferrous sulfate: ferric chloride = 1.4:2). Dissolving 16g of alginic acid with a weight-average molecular weight of 20,000 in 100 ml of concentrated ammonia water with a concentration of 25Wt% is made into a mixed solution of alginate ammonia water (aqueous ammonia: the mol ratio of ferric chloride is 40:1, and the alginic acid to tetroxide The mass ratio of tri-iron is 4:1). The iron salt mixed solution and the alginate ammonia mixed solution were mixed under stirring at 800 rpm, and then reacted under stirring for 50 minutes, and the reaction temperature was stabilized at 90°C. Step 2 and step 3 are the same as in Example 1, to obtain alginic acid-modified nano-iron tetroxide particles (the mass rat...

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Abstract

A magnetic nanoball carrying cisplatin is disclosed, which can be used as the medicine carrier to provide magnetic targetability. Its preparing process includes such steps as preparing the carboxypolyose modified Fe3O4 nanopartieles by chemical codeposition method under existence of carboxypolyose, and coordination between the free carboxy in carboxypolyose on the surface of Fe3O4 nanoparticle and Pt atoms for coupling the cisplatin with said nanoparticle. It can be used for the controlled slow-release medicine applying system.

Description

technical field [0001] The invention relates to the field of nanotechnology, in particular to a cisplatin-loaded nanosphere and a preparation method thereof. Background technique [0002] Cisplatin (Cis-dichlorodiamine platinum) is the most commonly used cell cycle non-specific high-efficiency anti-tumor drug in clinic. It can be used to treat ovarian cancer, testicular cancer, bladder cancer, gastrointestinal tumors, especially head and neck tumors. Its anticancer The main mechanism is to inhibit DNA replication by forming cross-links between DNA or between DNA and proteins. However, there are still many problems in cisplatin-based chemotherapy: ① Cisplatin has a low molecular weight and is transported too fast in the blood circulation, so it cannot exert its anti-cancer effect well; ② Intravenous administration, systemic chemotherapy, has large toxic and side effects; ③ After long-term chemotherapy, it is easy to lead to drug resistance in the body. In order to increase ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/282A61P35/00
Inventor 谢民强徐雪青沈辉李仲汉陈帅君许家瑞
Owner SUN YAT SEN UNIV
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