Chiral graphene quantum dot and preparation method and application

A graphene quantum dot and quantum dot technology, applied in the field of nanomaterials, can solve the problems of single application, less research on chiral nanomaterials, health and environmental hazards, etc., and achieve the effects of good water solubility, good fluorescence properties, and low cost.

Active Publication Date: 2016-08-03
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the research on chiral nanomedicine based on nanotechnology is of great significance, there are still few studies on chiral nanomaterials, and the biological activity of chiral nanomaterials, and its research in the field of disease treatment is even blank, and based on semiconductors, noble metals, etc. The heavy metal elements contained in chiral nanomaterials bring serious health and environmental hazards, so it is necessary to develop novel chiral nanomaterials free of heavy metals and explore their applications in the field of biomedicine
[0006] Graphene quantum dots are a new type of fluorescent carbon nanomaterial with a size below 10nm. They have excellent fluorescence stability, no "light flickering" phenomenon, good biocompatibility, low toxicity, easy functional modification of the surface, and a wide range of sources for preparation materials, etc. It has attracted extensive attention from researchers in the fields of materials science and other fields, but its current application is relatively single, mainly limited to the field of biological imaging

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  • Chiral graphene quantum dot and preparation method and application
  • Chiral graphene quantum dot and preparation method and application
  • Chiral graphene quantum dot and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Preparation of Chiral Graphene Quantum Dots

[0072] D-glutamic acid-modified chiral graphene quantum dots are synthesized by a bottom-up one-step small molecule pyrolysis method, and the specific steps are as follows:

[0073] (1) Weigh citric acid monohydrate (1.8g) and D-glutamic acid (0.2g), mix thoroughly, and add to a 5mL small beaker;

[0074] (2) Place the above-mentioned small beaker in a blast drying oven at 200°C. The white solid gradually melts and produces a large number of bubbles, and then the color gradually deepens. After about 25 minutes, the mixture turns into a reddish-brown liquid. Stop heating, and after cooling, Obtain dark orange solid sample;

[0075] (3) Add a certain amount of ultrapure water to dissolve, and adjust the pH value to 6 with a sodium hydroxide aqueous solution with a concentration of 10mol / L;

[0076] (4) The obtained product was purified by dialysis to completely remove unreacted small molecule amino acids, and the crude produ...

Embodiment 2

[0081] Preparation of Chiral Graphene Quantum Dots

[0082] The difference with embodiment 1 only lies in:

[0083] Replace the D-glutamic acid of step (1) with the mass such as L-glutamic acid, obtain L-Glu-GQD (L-glutamic acid modified graphene quantum dot).

Embodiment 3

[0085] Preparation of Chiral Graphene Quantum Dots

[0086] D-phenylalanine-modified chiral graphene quantum dots are synthesized by a bottom-up one-step small molecule pyrolysis method, and the specific steps are as follows:

[0087] (1) Weigh citric acid monohydrate (1.8g) and D-phenylalanine (0.3g), mix well, and add to a 5mL small beaker;

[0088] (2) Place the above-mentioned small beaker in a blast drying oven at 195°C, the white solid gradually melts and produces a large number of bubbles, and then the color gradually deepens. After about 30 minutes, the mixture turns into a reddish-brown liquid. Stop heating, and after cooling, Obtain dark orange solid sample;

[0089] (3) Add a certain amount of ultrapure water to dissolve, and adjust the pH value to 6 with a sodium hydroxide aqueous solution with a concentration of 10mol / L;

[0090] (4) The obtained product was purified by dialysis to completely remove unreacted small molecule amino acids, and the crude product was...

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Abstract

The invention relates to a chiral graphene quantum dot.The chiral quantum dot nano material is a single-layer graphene quantum dot modified with chiral amino acid.The chiral graphene quantum dot has the advantages that the chiral graphene quantum dot has the antibacterial property and is not prone to cause bacterial drug resistance, capable of selectively killing bacteria and free of toxicity to mammalian cells; the chiral graphene quantum dot is good in stability and water solubility and low in cost; the chiral graphene quantum dot has a novel chiral optical signal.

Description

technical field [0001] The present invention relates to the technical field of nanomaterials, in particular to a chiral graphene quantum dot, its preparation method and application, in particular to a graphene-based chiral quantum dot nanomaterial, its preparation method and its application in antibacterial, biological imaging, Applications in chiral sensing. Background technique [0002] Chirality refers to the characteristic that an object cannot coincide with its mirror image, just like the left and right hands of a human being. Chirality exists widely in nature. In the field of chemistry, molecules with this characteristic are called chiral molecules. Chiral molecules have a special property - optical activity, which can make the vibration plane of polarized light passing through it occur deflection at a certain angle. [0003] In the field of life sciences, the DNA of living organisms is composed of D-type sugar and deoxyribose, and almost all proteins are composed of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B31/04B82Y30/00A61K33/44A61K47/48A61P31/04B82Y40/00
CPCA61K33/44C01B2204/04C01B2204/32C01P2002/85C01P2004/02C01P2004/04C01P2006/60Y02A50/30
Inventor 宫建茹刘倩辛琪
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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