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Enteric gelatinous nutrient and method of preparing the same

An enteral nutrition, gel-like technology, applied in food preparation, pharmaceutical formula, food ingredients as viscosity modifiers, etc., can solve problems such as development expectations

Active Publication Date: 2009-03-18
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As mentioned above, there has been no enteral nutrient and its preparation method designed on the basis of considering the physical properties and state of the enteral nutrient in the stomach, and its development has been expected

Method used

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  • Enteric gelatinous nutrient and method of preparing the same
  • Enteric gelatinous nutrient and method of preparing the same
  • Enteric gelatinous nutrient and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Dissolution Rate of Nutrient Components of Gel-form Enteral Nutrition in Simulated Fluid in Stomach

[0102] Regarding the effect of viscosity modifiers (thickeners, viscosity modifiers, and viscous presenting substances) on the gel-like (viscous) enteral nutrition in the simulated fluid (model gastric content fluid) inside the stomach (sometimes referred to as " The influence of the dissolution rate (dissolution amount) of nutrients (protein) in the matrix") was studied.

[0103] There are two types of gastric content fluid in the model, an acidic aqueous solution (pH = 2) close to the original normal internal state of the stomach and a neutral aqueous solution (pH = 7). The dissolution rate is defined by the following formula.

[0104] That is, dissolution rate [-]=(weight of protein released into model gastric content fluid) / (weight of protein initially contained in enteral nutrition).

[0105] The state inside the stomach was experimentally studied by studying th...

Embodiment 2

[0133] Dissolution Rate of Nutrient Components of Gel-like Enteral Nutrition in Simulated Fluid in Stomach

[0134] Under the experimental conditions of simulating the peristaltic movement of the stomach and intestinal tract, the influence of the dissolution rate of the nutrient components of the gel-like enteral nutrition was studied. The experimental conditions are basically the same as in Example 1.

[0135] The difference in specific experimental conditions between Example 1 and Example 2 is as follows.

[0136] In the case of adding the gel-form enteral nutrition to the model gastric content fluid and maintaining it, it was maintained while shaking in Example 2, as opposed to standing still in Example 1. The oscillation conditions here are about 35 mm in amplitude and 120 times / min. In addition, the temperature in Example 2 was 37°C, compared to 25°C (normal temperature) in Example 1.

[0137] As in Example 1, each enteral nutrient (concentration of agar, carrageenan, ...

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Abstract

Provided is an enteric gelatinous nutrient which can be safely and easily taken by a patient with dysphagia or a patient under tube feeding without causing gastro-esophageal reflux and a method for preparing the same. An enteric gelatinous nutrient having an appropriate physical value as specified below for preventing a patient with dysphagia or a patient under tube feeding from gastro-esophageal reflux: namely, immediately after mixing the enteric gelatinous nutrient with an aqueous solution having a definite pH value at a weight ratio of 3:7 and gently stirring for 5 seconds, the elution ratio of nutritional components being from 0 to 0.2. An enteric gelatinous nutrient having a physical value as specified below: namely, after mixing the enteric gelatinous nutrient with an aqueous solution having a definite pH value at a weight ratio of 3:7, allowing the mixture to stand for 30 minutes and then gently stirring for 5 seconds, the elution ratio of nutritional components being from 0 to 0.45.

Description

technical field [0001] The present invention relates to an enteral nutrient that can be safely and easily ingested without gastroesophageal reflux and a preparation method thereof for patients with dysphagia or patients in the process of feeding through a tube. More specifically, the present invention relates to a gel-form enteral nutrient capable of appropriately controlling the physical properties and state of the enteral nutrient in the stomach during tube nutrition, etc., and to the gel-form enteral nutrition The invention relates to a preparation method of a gel-like enteral nutrition agent whose viscosity is adjusted. Background technique [0002] Enteral nutrition is a route of physiological administration of nutrition through the digestive tract, which can solve the problem of high-calorie infusion methods, so it has recently received renewed attention. [0003] On the other hand, tube nutrition is effective for patients with eating and swallowing disorders (dysphag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/08A61K38/00A61P3/02
CPCA23V2002/00A61K38/01A23L1/00A23L1/30A23L33/10A61P3/02A23V2200/244A23V2200/32A23V2250/5036A23V2250/5086A61K9/08A61K38/16A61K47/36
Inventor 外山义雄越膳浩
Owner MEIJI CO LTD
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