Implant as well as preparation method and application thereof

An implant and implant technology, applied in the field of medical devices, can solve the problems of no sterilization and anti-inflammatory, and the drug can not be released uniformly and slowly, and achieve the effect of reducing pain, good control release effect, and small release amount.

Inactive Publication Date: 2019-09-27
TONGYAN (SHANGHAI) MEDICAL EQUIPMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] CN103491884A discloses a kind of suture, which is used to complete the suture without tying some or all of the knots that should be tied during suture. This invention provides a suture support, which supports to prevent the end of the suture from being pulled into A suturing part, a needle accommodating body having the shape of a pipe with through holes penetrating both ends, and a suture thread having the suture thread supporting body and the needle accommodating body, the suture thread having good suture effect, but it does not have the effect of sterilization and anti-inflammation
[0008] CN109224118A discloses a medical surgical suture, the disclosed medical surgical suture has the advantages of complete absorption, high tensile strength, good biocompatibility, can promote cell growth, and has the advantages of sterilization, anti-inflammation and hemostasis, but its drug Can not play a uniform and slow release effect

Method used

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  • Implant as well as preparation method and application thereof
  • Implant as well as preparation method and application thereof
  • Implant as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] This embodiment provides an implant, figure 1 is a schematic diagram of an implant, such as figure 1 As shown, the implant includes a bell wire and a drug coating 1 sprayed on the surface of the bell wire, the bell wire includes a wire body 2 and at least a plurality of bell parts 3, the wire body 1 runs through the bell part 3, and the bell part 3 includes The inside of the thread body and the outside away from the thread body, wherein the drug coating 1 is coated on the surface of the thread body 2 and the outer surface of the bell part 3; the drug coating 1 includes drugs and controlled release factors; wherein the drug is mometasone furoate, controlled release The factor is polylactic acid-glycolic acid (the content of polylactic acid structural unit in polylactic acid-glycolic acid is 50%, and the content of glycolic acid structural unit is 50%); the thickness of the drug coating is 0.02mm; a single implant The drug dose is 3mg.

[0076] This embodiment also prov...

Embodiment 2

[0082] This embodiment provides an implant, image 3 is a schematic diagram of an implant, such as image 3As shown, the implant includes a barb line and a drug coating 1 sprayed on the surface of the barb line. The barb line includes a line body 2 and at least a plurality of barbs 4. The barb 4 is set on the line body 2, wherein the drug Coating 1 is coated on the outer surface of thread body 2 and barb 4; drug coating 1 includes drug and controlled release factor; wherein the drug is a combination of aspirin and lidocaine, and the controlled release factor is polydioxanone ; The thickness of the drug coating is 0.03mm, the amount of aspirin carried by a single implant is 3 mg, and the amount of drug carried by lidocaine is 1.25 mg.

[0083] This embodiment also provides a preparation method of the implant, the preparation method comprising the following steps:

[0084] (1) 800mg of aspirin, 200mg of lidocaine and 1500mg of polydioxanone were dissolved in 50mL of dichlorome...

Embodiment 3

[0089] This embodiment provides an implant, including a bell wire and a drug coating sprayed on the surface of the bell wire. The structure of the implant is the same as in Example 1, and the drug coating includes a drug, a release-controlling factor, and a hydrophilic polymer; Wherein the medicine is mometasone furoate, and the controlled-release factor is polylactic acid-glycolic acid (wherein the content of polylactic acid structural unit in polylactic acid-glycolic acid is 50%, and the content of glycolic acid structural unit is that mass ratio is 50%:50% ), the hydrophilic polymer is polyethylene glycol; the thickness of the drug coating is 0.02mm, and the amount of drug carried by a single implant of mometasone furoate is 3mg.

[0090] This embodiment also provides a preparation method of the implant, the preparation method comprising the following steps:

[0091] (1) 1500mg of mometasone furoate, 1700mg of polylactic acid-glycolic acid and 300mg of polyethylene glycol w...

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Abstract

The invention provides an implant as well as a preparation method and application thereof. The implant comprises an implant suture and a drug coating arranged on the surface of the implant suture, wherein the drug coating comprises a drug and a controlled release factor. According to the implant provided by the invention, the implant can achieve an effect of quantitatively and slowly releasing the drug so as to eliminate or reduce pain, inflammatory swelling, infection and other risks in the implantation process on the basis of ensuring that the implant can be smoothly implanted into the human body, and a high-efficiency treatment effect can be achieved at a small dosage; moreover, by modifying the surface of the implant suture, good adhesion is maintained between the implanted implant suture and the drug coating. The drug coating is sprayed onto the implant suture in a spray manner, so that the drug on the surface of the implant suture can be uniformly dispersed, and convenience is brought to uniform and stable release of the drug. The implant is simple in preparation method, readily available in raw materials and easy to realize and has excellent effects in aspects such as inflammation control and swelling subsidence.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to an implant, its preparation method and application. Background technique [0002] Due to factors such as age and environment, the soft tissue and bone volume of the human face will shrink, the ligaments will begin to relax, and the superficial muscle fascia system will gradually sag. Decreased elasticity, increased wrinkles, deepened groove formation, etc. And with the increase of age, the hormone level in the body changes, the loss of collagen and the atrophy of facial glands and other factors together make the face show an undesirable characteristic change-aging. [0003] With the progress and development of society, people's demand for beauty is gradually increasing, especially for the rejuvenation of the face, and there is an increasing trend year by year. Related surgery has always been the focus of plastic and cosmetic surgery research. [0004] At present, to improve and mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14
CPCA61L31/10A61L31/14A61L31/16A61L2300/402A61L2300/406A61L2300/41A61L2300/43A61L2300/604A61L2300/606C08L67/04C08L5/08
Inventor 夏佩佩晏伟魏征
Owner TONGYAN (SHANGHAI) MEDICAL EQUIPMENT CO LTD
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