Drug-loaded Prussian blue and manganese fibrin composite gel, and preparation method and application thereof

Abstract

The invention belongs to the field of biological medicine, and provides drug-loaded Prussian blue and manganese fibrin composite gel, and a preparation method and application thereof. Mesoporous Prussian blue nanoparticles are etched to form hollow Prussian blue nanoparticles; the hollow Prussian blue nanoparticles are coated with manganese ions to form hollow Prussian blue and manganese nanoparticles; the hollow Prussian blue and manganese nanoparticles are subjected totargeted modification; holes of the hollow Prussian blue and manganese nanoparticles are loaded with a sound-sensitive agent and coated with oligomeric hyaluronic acid; and finally, it is mixed with a fibrinogen solution under the stimulation of thrombin to form the composite gel. According to the invention, the novel sound-sensitive agent is loaded in the holes of the hollow Prussian blue nanoparticles; the oligomeric hyaluronic acid is modified on the outer surface, so that the targeting effect can be achieved, and the immunosuppressive microenvironment of tumors can be adjusted; and the composite gel not only can realize the enhanced sonodynamic-immune synergistic treatment effect on postoperative residual tumor tissues, but also can accelerate the repair and healing of postoperative wounds.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a drug-loaded Prussian blue@manganese fibrin composite gel, a preparation method and an application thereof. Background technique [0002] Cancer is one of the major diseases that endanger human health. Clinically, the main strategies for the treatment of cancer can be divided into: surgery, radiotherapy, chemotherapy and biological therapy. Surgical treatment is still the most important method in clinical treatment, but the high recurrence rate of cancer after surgery is still an urgent problem to be solved. Sonodynamic therapy (SDT) is a new anti-tumor treatment method established and developed on the basis of photodynamic therapy. The function of SDT is based on the synergistic effect of three substances: sound sensitizer, ultrasonic wave and oxygen. SDT mainly uses ultrasound to penetrate deep into the tissue, activate sound-sensitizers such as porphyrin and its deri...

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Problems solved by technology

[0008] The purpose of the present invention is to overcome the deficiencies of the existing preparations, and provide drug-loaded Prussian blue@manganese fibrin composite gel and its preparation method and application. It activates immune pathways, realizes the therapeutic effect of sonodynamics-immunity synergy, and also promotes the repair and healing of wounds, thereby solving the problems of low bioavailability, high toxicity, and multidrug resistance in current treatments.

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