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Method for preparing ultrahigh-drug-loaded nanoparticles by sequential precipitation and complexation coacervation technology

A drug-carrying nanotechnology and agglomeration method, which is used in pharmaceutical formulations, active ingredients of heterocyclic compounds, and medical preparations with non-active ingredients.

Active Publication Date: 2018-10-23
刘东飞 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a method for preparing ultra-high drug-loaded nanoparticles by an ultra-fast sequential precipitation complexation coagulation method, which can well solve some problems faced by traditional nano-drug delivery systems

Method used

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  • Method for preparing ultrahigh-drug-loaded nanoparticles by sequential precipitation and complexation coacervation technology
  • Method for preparing ultrahigh-drug-loaded nanoparticles by sequential precipitation and complexation coacervation technology
  • Method for preparing ultrahigh-drug-loaded nanoparticles by sequential precipitation and complexation coacervation technology

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Embodiment 1

[0100] like figure 1 As shown, this embodiment discloses a preparation device for ultra-high drug-loaded nanoparticles, including a first reactor 1 and a second reactor 2; the first reactor includes a first inlet 1a, a second inlet 1b and a first outlet 1c, the second reactor comprises a third inlet 2a and a fourth inlet 2b.

[0101] Optional situation 1: the first inlet 1a is used to add the first reactant, and the first reactant enters the first reactor 1 through the first inlet 1a; the second inlet 1b is used to add the second reactant, and the second inlet 1b is used to add the second reactant. Two reactants along figure 1 The direction of the arrow next to the second inlet 1b enters the first reactor 1; the first reactor 1 is used to accommodate the reaction of the first reactant and the second reactant. Optional situation 2: the first inlet 1a is used to add the second reactant, and the second reactant enters the first reactor 1 through the first inlet 1a; the second i...

Embodiment 2

[0105] like figure 2 As shown, the difference between this embodiment and embodiment 1 is that the pre-accommodating chamber 3 is not used, the first inlet and the first reactor are arranged on the same straight line, and the first reactor and the second reactor are arranged on the same straight line . There are two second inlets, which are respectively perpendicular to the straight line formed by the first inlet and the first reactor. There are two third inlets, which are respectively perpendicular to the straight line formed by the first reactor and the second reactor. The first reactant and the second reactant enter the first reactor through the first inlet and the second inlet respectively, or the first reactant and the second reactant enter the first reactor through the second inlet and the first inlet respectively. Interchanging the piping of the first reactant and the second reactant into the first reactor does not affect the production of nanoparticles. This exampl...

Embodiment 3

[0107] like image 3 As shown, the difference between this embodiment and embodiment 2 is that there is one second inlet, and the first inlet and the second inlet are respectively obliquely connected to the first reactor, forming an incident angle with the first reactor ( 0 to 180 degrees), and the rest are the same. The first reactant and the second reactant enter the first reactor through the first inlet and the second inlet respectively, or the first reactant and the second reactant enter the first reactor through the second inlet and the first inlet respectively. Interchanging the piping of the first reactant and the second reactant into the first reactor does not affect the production of nanoparticles. This example is directed to a reactor prepared by using polymer materials such as PDMS. The dashed part in the middle indicates that the length of the reactor can be adjusted.

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Abstract

The invention discloses a method for preparing ultrahigh-drug-loaded nanoparticles by a sequential precipitation and complexation coacervation technology. The method comprises the following steps: mixing a first reactant with a second reactant in a first reactor to make active drug components precipitate in the first reactor in order to form a drug nanoparticle core; and allowing the reaction product of the first reactor to rapidly flow into a second reactor and be mixed with a third reactant, and carrying out a complexation coacervation reaction on a shell material to make the shell materialdeposited on the surface of the drug nanoparticle core in order to form the ultrahigh-drug-loaded nanoparticles with a core-shell structure.

Description

technical field [0001] The invention relates to a method for preparing ultrahigh drug-loaded nanoparticles by a sequential precipitation complexation coagulation method, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] The development of nanotechnology has greatly accelerated research in medical science. The application of nanotechnology to the prevention, diagnosis and treatment of diseases is called nanomedicine. The global market for nanomedicine will increase from US$5.5 billion in 2011 to US$12.7 billion in 2016. Nano drug delivery systems, such as nanoparticle carriers, are mainly composed of lipid materials and / or polymers, as well as their entrapped therapeutic drugs [1] , can improve the curative effect of traditional medicine. Although some nano-drug delivery systems have been successfully applied to the diagnosis and treatment of clinical diseases, such as cancer, pain and infection, there are still many aspects t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/24A61K47/26A61K31/337A61K31/12A61K31/44A61K31/635A61K38/13
CPCA61K9/5123A61K9/5146A61K9/5169A61K9/5192A61K31/12A61K31/337A61K31/44A61K31/635A61K38/13A61K9/51A61K47/24A61K47/26
Inventor 刘东飞海尔德A.桑托斯凡进殷国勇
Owner 刘东飞
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