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Composite nano-particles used in inorganic photodynamic therapy, and preparation method thereof

A technology of composite nanoparticles and photodynamic therapy, which is applied in the direction of medical preparations containing active ingredients, wave energy or particle radiation treatment materials, drug combinations, etc. Tissue damage and other problems, to achieve the effect of avoiding weak penetration of ultraviolet light, low biological toxicity, and suitable particle size

Active Publication Date: 2014-06-25
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, nano-TiO 2 or ZrO 2 The photodynamic therapy function generally requires the excitation of ultraviolet light. Due to the weak penetration ability of ultraviolet light in body tissues, it cannot effectively reach the target area, and the direct irradiation of ultraviolet light will cause damage to human skin and other body tissues. Major damage
At present, there are no reports on the research and application of inorganic photodynamic therapy reagents excited by infrared light

Method used

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  • Composite nano-particles used in inorganic photodynamic therapy, and preparation method thereof
  • Composite nano-particles used in inorganic photodynamic therapy, and preparation method thereof
  • Composite nano-particles used in inorganic photodynamic therapy, and preparation method thereof

Examples

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Embodiment 1

[0038] (1) Firstly, upconversion luminescent nanoparticles were prepared, and Y(NO 3 ) 3 , Yb(NO 3 ) 3 and Tm(NO 3 ) 3 The aqueous solution is mixed and stirred according to the molar ratio of 8.9:1.0:0.1, and then 12.5 mL of an aqueous solution of 0.1 M sodium citrate and 30 mL of an aqueous solution of 0.5 M sodium fluoride are sequentially added thereto as a modifier and a complexing agent, and Stir for 1 hour. Put the mixed solution into the reaction kettle, and conduct a hydrothermal reaction at 120°C for 2 hours to obtain NaYF 4 :Yb 3+ / Tm 3+ Nanoparticles, the product is cleaned and purified.

[0039] (2) The prepared NaYF 4 :Yb 3+ / Tm 3+ Re-disperse 100mg of nanoparticles into 50mL of ethanol / water mixed solution, ultrasonically disperse, control the ratio of alcohol to water to 4:1, then add 1mL of 0.1M tetrabutyl titanate ethanol solution to it, and fully stir at 70°C 1 hour;

[0040] (3) After the reaction is completed, the product is cleaned and purifi...

Embodiment 2

[0048] (1) Firstly, upconversion luminescent nanoparticles were prepared, and Y(NO 3 ) 3 , Yb(NO 3 ) 3 and Tm(NO 3 ) 3 The aqueous solution is mixed and stirred according to the molar ratio of 7.8:2.0:0.2, and then 10mL of 0.1M sodium citrate aqueous solution and 0.5M sodium fluoride aqueous solution 25mL are sequentially added thereto as modifier and complexing agent, and stirred 1 hour. Put the mixed solution into the reaction vessel, and conduct a hydrothermal reaction at 180°C for 2 hours to obtain NaYF 4 :Yb 3+ / Tm 3+ Nanoparticles, the product is cleaned and purified.

[0049] (2) The prepared NaYF 4 :Yb 3+ / Tm 3+ Re-disperse 100mg of nanoparticles into 50mL aqueous solution, ultrasonically disperse, then add 5mL of 0.1M titanium tetrachloride aqueous solution to it, and fully stir for 1 hour in an ice bath;

[0050] (3) Add NH dropwise to the above reaction vessel 3 ·H 2 O solution, adjust its pH value between 7.0-8.0, and fully stir for more than 2 hours;...

Embodiment 3

[0054] (1) Firstly, upconversion luminescent nanoparticles were prepared, and Y(NO 3 ) 3 , Yb(NO 3 ) 3 and Tm(NO 3 ) 3 The aqueous solution is mixed and stirred according to the molar ratio of 8.9:1.0:0.1, and then 15 mL of an aqueous solution of 0.1 M sodium citrate and 30 mL of an aqueous solution of 0.5 M sodium fluoride are sequentially added thereto as modifiers and complexing agents, and stirred 1 hour. Put the mixed solution into the reaction kettle, and conduct a hydrothermal reaction at 120°C for 6 hours to obtain NaYF 4 :Yb 3+ / Tm 3+ Nanoparticles, the product is cleaned and purified.

[0055] (2) The prepared NaYF 4 :Yb 3+ / Tm 3+ Nanoparticles 100mg are redispersed in the mixed solution of 15mL of oleic acid / oleylamine / ethanol, the volume ratio of oleic acid / oleylamine / ethanol is 3:2:10, then add the tetrabutyl titanate of 0.1M wherein 10mL ethanol solution, after fully stirring, carry out hydrothermal reaction at 180°C for 12 hours;

[0056] (3) After ...

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Abstract

The invention discloses composite nano-particles used in inorganic photodynamic therapy, and a preparation method thereof. According to the invention, nano-particles with an up-conversion luminescence property under infrared light excitation are composed with TiO2, ZrO2 or Zr-Ti-O nano-particles with good biocompatibility with cell killing property under ultraviolet light irradiation, such that composite nano-particles are prepared. The composite nano-particles can be adopted as a near-infrared-light-excited novel inorganic photodynamic therapy reagent, and has characteristics of good body tissue penetration capacity, good safety, and no damage. Because the particles have nano-grade dimensions, the retention time of the nano-particles in bodies is long, and the nano-particles have stability better than that of traditional organic photo-sensitizers. Therefore, the nano-particles have important application potential in photodynamic therapies of malignant tumors.

Description

technical field [0001] The invention relates to an inorganic photodynamic therapy agent, in particular to an inorganic photodynamic therapy agent excited by near-infrared light and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards and the continuous development of medical technology, non-invasive, low-injury, efficient and sensitive treatment methods and technologies have been widely concerned. Due to the characteristics of high efficiency, non-invasiveness and good selectivity, photodynamic therapy has become one of the research hotspots in the fields of clinical medicine, chemistry, materials science and biomedicine. Photodynamic therapy generally utilizes a carried photosensitizer to irradiate the lesion with an external light source to stimulate the photosensitizer molecules to generate singlet oxygen and kill the diseased cells. Especially after coupling the up-conversion luminescent nanoparticles w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/24A61P35/00
Inventor 曾乐勇吴爱国
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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