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Preparation method of novel composite anti-coccidium, antibiotic preparation

An anti-coccidial and preparation technology, applied in the directions of antibacterial drugs, anti-infective drugs, pharmaceutical formulations, etc., can solve the problems of reducing the effective use concentration of drugs, poor water solubility of trimethoprim, and insignificant effects, etc. Good absorption and bioavailability, pharmaceutical stability and safety, low cost effect

Active Publication Date: 2010-09-29
PU LIKE BIO ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The onset of coccidiosis is characterized by loss of appetite and increased drinking water, so choosing granules for drinking water can have a better therapeutic effect. Sulfachlorpyrazine sodium is a kind of chicken coccidiosis that has a better effect. Drug, and combined with trimethoprim can enhance its antibacterial activity, but the water solubility of trimethoprim is not good, which reduces the effective concentration of the drug, resulting in large dosage and insignificant effects.

Method used

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  • Preparation method of novel composite anti-coccidium, antibiotic preparation
  • Preparation method of novel composite anti-coccidium, antibiotic preparation

Examples

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Effect test

Embodiment 1

[0040] A kind of compound anti-coccidian, antibacterial preparation, it is the medicament that is made of sulfachlorpyrazine sodium and trimethoprim as raw material, gets trimethoprim 0.6kg, adds 12L glacial acetic acid, lukewarm makes dissolving, drips into 240L, Cyclodextrin saturated aqueous solution at 75°C, stirred for 30 minutes, stopped heating and continued to stir for 5 hours, a white precipitate was obtained, left at room temperature for 12 hours, filtered, the precipitate was dried at 60°C, passed through a 80-mesh sieve, and passed through a P 2 o 5 Vacuum-dried to obtain the clathrate. Mix the clathrate with 3 kg of sulfachlorpyrazine sodium and appropriate amount of glucose powder to 10 kg, mix them evenly, and make granules through a boiling drying granulator to obtain the product.

Embodiment 2

[0042] A kind of compound anti-coccidia, antibacterial preparation, it is the medicament that is made of sulfachlorpyrazine sodium and trimethoprim as raw material, gets trimethoprim 0.5kg, adds 10L glacial acetic acid, lukewarm makes dissolving, drips into 200L, Cyclodextrin saturated aqueous solution at 75°C, stirred for 30 minutes, stopped heating and continued to stir for 5 hours, a white precipitate was obtained, left at room temperature for 12 hours, filtered, the precipitate was dried at 60°C, passed through a 80-mesh sieve, and passed through a P 2 o 5 Vacuum-dried to obtain the clathrate. Mix the clathrate with 2.5kg of sulfachlorpyrazine sodium and appropriate amount of glucose powder to 10kg, stir evenly, and make granules through a boiling drying granulator to obtain the product.

Embodiment 3

[0044] A kind of compound anti-coccidia, antibacterial preparation, it is the medicament that is made by sulfachlorpyrazine sodium and trimethoprim as raw material, gets trimethoprim 0.7kg, adds 14L glacial acetic acid, lukewarm makes dissolving, drips into 280L, Cyclodextrin saturated aqueous solution at 75°C, stirred for 30 minutes, stopped heating and continued to stir for 5 hours, a white precipitate was obtained, left at room temperature for 12 hours, filtered, the precipitate was dried at 60°C, passed through a 80-mesh sieve, and passed through a P 2 o 5 Vacuum-dried to obtain the clathrate. Mix the clathrate with 3.5 kg of sulfachlorpyrazine sodium, and appropriate amount of glucose powder to 10 kg, mix, stir evenly, and make granules through a boiling drying granulator to obtain the product.

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Abstract

The invention discloses a preparation method of a novel compound anti-coccidiosis and antibacterial preparation which is prepared by taking sulfachloropyrazine sodium and trimethoprim as raw materials. The preparation method comprises the steps of: taking 0.5kg to 0.7kg of trimethoprim, adding 10l to 14l of glacial acetic acid to form a mixture, heating the mixture slightly to dissolve the trimethoprim and the glacial acetic acid, dropping 200l to 280l of cyclodextrin saturated water solution with at temperature of 75 DEG C, stirring the mixture for 30min, stopping heating and continuously stirring for 5h to obtain a white sediment, filtering the mixture after being rested at room temperature for 12h, drying the sediment at 60 DEG C, sieving the sediment by an 80-mesh sieve, and drying the sediment by P2O5 in vacuum to obtain a clathrate. The clathrate is mixed with 2.5kg to 3.5kg of sulfachloropyrazine sodium and glucose of a proper amount up to 10kg, evenly mixed and made into particles by a fluidized drying granulator to obtain the finished product. The compound anti-coccidiosis and antibacterial preparation has efficient and quick therapeutic effect on explosive coccidiosis (caecal coccidiosis) of poultry, rabbits, and the like, and on mixed infections caused by various bacteria, such as chicken cholera, typhoid and the like.

Description

Technical field: [0001] The invention relates to a preparation method of veterinary medicine, in particular to a preparation method of compound anticoccidial and antibacterial preparations. Background technique: [0002] In recent years, my country's poultry industry has developed rapidly, and its inventory has leapt to the first place in the world. It has gradually developed towards scale, intensification and modernization. However, my country's overall breeding management level is relatively backward, and poultry diseases have always been It is an important factor restricting the development of my country's poultry industry, especially coccidiosis is one of the decisive factors restricting the success or failure of intensive chicken farming. Insect medicine. It can be said that wherever there are chickens, there is chicken coccidiosis. Intensive chicken farms are the most suitable places for coccidiosis outbreaks. The incidence rate is 50%-70%, and the mortality rate is 20%...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K9/16A61P31/04A61P33/02A61K31/505
Inventor 张许科刘兴金张晓会李兴国朱华伟蔡敏孙雪峰张志娟
Owner PU LIKE BIO ENG
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