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Drug carrier system based on supramolecular recognition self-assembly as well as preparation method and application thereof

A carrier system and self-assembly technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of poor solubility, instability, low bioavailability, etc. Bacteria sterilize infection, prevent infection, and reduce the burden of degradation and metabolism

Pending Publication Date: 2020-03-06
上海曜爱生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most active substances are hydrophobic or insoluble molecules, which have problems such as poor solubility, instability, and low bioavailability

Method used

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  • Drug carrier system based on supramolecular recognition self-assembly as well as preparation method and application thereof
  • Drug carrier system based on supramolecular recognition self-assembly as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0048] In a 100mL beaker, take 3.0g of β-glucan and 1.0g of chitosan, add 20mL of deionized water, stir mechanically at room temperature, stir and swell for 8 hours at a stirring speed of 500r / min, and obtain a transparent Viscous gel-like product. Then carry out intermolecular self-assembly. Specifically, transfer the obtained transparent and viscous gel-like product into a closed container, place it in a freezer at -25°C, freeze it for 12 hours, then take it out, and thaw it at room temperature for 12 hours. Freezing-thawing was repeated 5 times to obtain a transparent jelly-like product; then freeze-dried for 24 hours to obtain a white flocculent solid. The sample was numbered 001 and stored at 4°C for future use.

preparation Embodiment 2

[0050] In a 100mL beaker, take 3.0g of β-glucan and 0.3g of ε-polylysine, add 20mL of deionized water, stir mechanically at room temperature, stir and swell for 8 hours at a stirring speed of 500r / min, A clear, low-viscosity solution was obtained. Then carry out intermolecular self-assembly, specifically transfer the transparent low-viscosity solution into a closed container, place it in a freezer at -25°C, freeze it for 12 hours, then take it out, and thaw it at room temperature for 12 hours, so freeze-thaw Repeat 5 times to obtain a transparent low-viscosity solution, and then freeze-dry for 24 hours to obtain a white flocculent solid. The sample was numbered 002 and stored at 4°C for future use.

preparation Embodiment 3

[0052] In a 100mL beaker, take 3.0g of β-glucan and 3.0g of sodium alginate, add 20mL of deionized water, stir mechanically at room temperature, and stir and swell for 8 hours at a stirring speed of 500r / min to obtain a transparent medium viscosity solution. Then perform intermolecular self-assembly, specifically transfer the transparent medium-viscosity solution into a closed container and place it in a freezer at -25°C for 12 hours, then take it out and thaw it at room temperature for 12 hours, and freeze-thaw repeatedly 5 times, a transparent jelly-like gel was obtained, and then freeze-dried for 24 hours to obtain a white flocculent solid. The sample was numbered 003 and stored at 4°C for future use.

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Abstract

The invention relates to a slow-release system of a supramolecular structure, in particular to a drug carrier system based on supramolecular recognition self-assembly as well as a preparation method and an application thereof. The drug carrier system provided by the invention is formed by self-assembling beta-glucan and a high-molecular compound with positive charges; wherein the high-molecular compound is selected from polysaccharides, polypeptides or compositions or polymers of polysaccharides and polypeptides. The drug carrier system provided by the invention has important application valuein the aspects of active drug wrapping and delivery.

Description

technical field [0001] The invention relates to a supramolecular structure sustained-release system, in particular to a drug carrier system based on supramolecular recognition self-assembly and its preparation method and application. Background technique [0002] In the field of medicine, most anti-tumor, anti-oxidant and anti-inflammatory drugs such as paclitaxel, curcumin and evodiamine are hydrophobic compounds that are insoluble in water. Therefore, when the drug is administered orally, due to incomplete absorption, the bioavailability of the drug is reduced, thereby affecting the therapeutic effect; and when the drug is injected intravenously, the drug is prone to aggregation due to low solubility and causes vascular obstruction, resulting in serious side effects. It may also cause poisoning reactions or even life-threatening. In the field of daily chemical products, most bioactive ingredients, such as β-carotene, vitamin E, coenzyme Q10, hesperidin and hesperetin, are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/36A61K47/34A61K8/88A61K8/73A61K8/02A61Q9/00
CPCA61K8/022A61K8/73A61K8/733A61K8/736A61K8/88A61K9/19A61K47/34A61K47/36A61K2800/84A61Q9/00
Inventor 孙乐青赵瑾贺琼雯
Owner 上海曜爱生物科技有限公司
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