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Elastic membrane, and preparation method and application thereof

A technology of elastic membrane and elastic mold, which is applied in the field of medical devices, can solve the problems of patients with great side effects, reduce the probability of adhesion, and increase the endometrium, etc., and achieve the effect of long drug test cycle, stable release, and stable drug release

Active Publication Date: 2019-06-25
YIPURUN SHANGHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Most of the above-mentioned treatment methods only temporarily reduce the chance of adhesion. After the effect of the device or drug disappears, the probability of re-adhesion is very high, especially for patients with moderate to severe adhesions.
It is a difficult problem to grow the endometrium, especially the endometrium that has destroyed the basal layer. Large doses of oral drugs have little effect on the endometrium that has damaged the basal layer, and have great side effects on patients.

Method used

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  • Elastic membrane, and preparation method and application thereof
  • Elastic membrane, and preparation method and application thereof
  • Elastic membrane, and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0074] This embodiment provides an elastic membrane, the elastic membrane includes a drug storage area and silicone rubber coated on the surface of the drug storage area, the drug storage area includes silicone rubber for the drug core and medicine, wherein the thickness of the silicone rubber is 0.02mm, The elastic modulus is 0.7MPa, and the crosslink density is 2000g / mol; the thickness of the drug storage area is 0.2mm, and the elastic modulus is 1.3MPa; the shortest distance from the edge of the drug storage area to the edge of the silicone rubber is 3mm; the drug is estradiol , the particle size is 2000 mesh; the content of estradiol in one of the elastic membranes is 100mg.

[0075] This embodiment also provides a preparation method of an elastic film, the preparation method is as follows:

[0076] (1) Mix 5g 17βestradiol (average particle size 2000 mesh), 30g HTV medical silicone rubber (molecular weight 20-1 million), 10g silicon dioxide, 5g hydroxyl silicone oil, 6g me...

Embodiment 2

[0084] This embodiment provides an elastic membrane, the elastic membrane includes a drug storage area and silicone rubber coated on the surface of the drug storage area, the drug storage area includes silicone rubber for the drug core and medicine, wherein the thickness of the silicone rubber is 0.02mm, The elastic modulus is 0.7MPa, and the crosslink density is 2000g / mol; the thickness of the drug storage area is 0.2mm, and the elastic modulus is 1.3MPa; the shortest distance from the edge of the drug storage area to the edge of the silicone rubber is 5mm; the drug is estradiol , the particle size is 2000 mesh; the content of estradiol in one of the elastic membranes is 100mg. This embodiment also provides a preparation method of an elastic film, the preparation method is as follows:

[0085] (1) 5g 17βestradiol (average particle size 2000 mesh), 3g Span 20, 30g HTV medical silicone rubber (molecular weight 20-1 million), 10g silicon dioxide, 5g hydroxyl silicone oil, 6g med...

Embodiment 3

[0091] This embodiment provides an elastic membrane, the elastic membrane includes a drug storage area and silicone rubber coated on the surface of the drug storage area, the drug storage area includes silicone rubber for the drug core and medicine, wherein the thickness of the silicone rubber is 0.5mm, The elastic modulus is 0.5MPa, and the crosslinking density is 5000g / mol; the drugs are estradiol and aspirin, and the particle size of estradiol is 5000 mesh; the content of estradiol in one elastic film is 50mg, and the content of aspirin is 10mg .

[0092] This embodiment also provides a preparation method of an elastic film, the preparation method is as follows:

[0093] (1) Mix 5g of 17βestradiol (average particle size 5000 mesh), 1g of aspirin, 3g of silicon dioxide, 0.5g of simethicone, 0.3g of povidone and 4g of distilled water, and put an appropriate amount in the mold Molded into a drug core to make a drug storage area containing 50 mg of estradiol and 10 mg of aspir...

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Abstract

The invention provides an elastic membrane, and a preparation method and application thereof. The elastic membrane comprises a silicone rubber and a medicine. The medicine is coated inside the silicone rubber in a mode of a medicine storage area, and the medicine comprises estrogen. The elastic membrane achieves an efficient therapeutic effect through micro-release of the medicine, and the medicine release is more stable. The elastic membrane has a longer medicine release cycle and better slow release capacity and is used for treatment of uterine cavity damage in a medicine slow-release system. The method for preparing the elastic membrane is simple, raw materials are easy to obtain, the price is low, and industrial large-scale production application is facilitated.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to an elastic membrane, a preparation method and an application. Background technique [0002] The uterus is an organ that produces menstruation and conceives a fetus. It is located in the center of the pelvic cavity and is a unique organ for women. The size of the uterus is related to age and fertility. A nulliparous person is about 7.5cm long, 5cm wide, and 3cm thick. The uterus can be divided into three parts: the bottom, the body, and the neck. The uterine cavity is an inverted triangle, about 6cm deep, and the upper two corners are "uterine horns", which lead to the fallopian tubes. The narrow lower end is the "isthmus", about 1cm long. [0003] Miscarriage, ring removal, surgery and other uterine operations, as well as infection, will cause various lesions in the uterus area. Uterine disease is one of the most common diseases in women, which seriously affects the normal life and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14A61L31/16
CPCA61L31/06A61L31/14A61L31/16A61L2300/43C08L83/04A61K31/565B29B7/7495B29B7/002A61M31/002A61M2210/1433B29C48/16B29C48/022A61K9/0039A61M31/007C08J5/18C08J7/0427C09D183/04C08L83/00C08K3/30C08K3/22C08K5/14C08K2003/2272C08K2003/3045A61K47/32A61M31/00B29B7/90B29L2007/002A61M2205/0216B29K2083/00B29K2509/02B29K2105/0035B29C48/07
Inventor 夏佩佩魏征晏伟杨瑞
Owner YIPURUN SHANGHAI BIOTECH CO LTD
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