98results about "Contraceptive devices" patented technology

A method for reducing mitral regurgitation includes deploying deforming matter into a selected one of (i) a mitral valve annulus adjacent a posterior leaflet, and (ii) tissue adjacent the mitral valve annulus and proximate the posterior leaflet, to cause conformational change in the mitral valve annulus to increase mitral valve leaflet coaptation.

Medical devices (100) and methods for delivery or implantation of prostheses (106) within hollow body organs and vessels (600) or other luminal anatomy are disclosed. The subject technologies may be used in the treatment of atherosclerosis in stenting procedures or for other purposes.

The present invention relates to implantable or insertable medical devices that treat uterine and urological conditions that cause chronic pelvic pain and other symptoms. In another aspect, the present invention relates to methods of manufacturing such implantable or insertable medical devices.

Medical devices (100) and methods for delivery or implantation of prostheses (106) within hollow body organs and vessels (600) or other luminal anatomy are disclosed. The subject technologies may be used in the treatment of atherosclerosis in stenting procedures or for other purposes.

The present invention relates to implantable or insertable medical devices that treat uterine and urological conditions that cause chronic pelvic pain and other symptoms. In another aspect, the present invention relates to methods of manufacturing such implantable or insertable medical devices.

Devices for treatments of diseases and disorders associated with the gastrointestinal tract, especially the stomach, or urinogenital tract are described herein. Initially, the device is in a temporary form which is suitable for oral or rectal administration. After exposure to a stimulus, such as a temperature or pH change, the device changes shape to a permanent form, which allows it to become mechanically fixed in the stomach, esophagus or intestine. In one embodiment, the device is used to reduce the volume of the stomach, esophagus or intestine without interfering with the flow of the food through the gastrointestinal tract. The device may be used to help overweight patients lose weight and to deliver drugs to treat disorders and diseases in the in the stomach or intestine. The devices are manufactured from a stimuli-sensitive polymeric material, which is biocompatible and primarily adapted to the mechanical properties and geometry in the area to which it is applied. In the preferred embodiment, the material is a shape memory polymer. Depending on the desired application, the polymer may be either biodegradable or non-degradable.

A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the core, where at least one of the core and membrane, when present, is made of a siloxane-based elastomer composition including at least one elastomer and optionally a non-crosslinked polymer. The device is characterized in that the elastomer composition includes poly(alkylene oxide) groups and that the poly(alkylene oxide) groups are present in the elastomer or polymer as alkoxy-terminated grafts of polysiloxane units, or as blocks, the grafts or blocks being linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms.

The invention relates to a siloxane-based elastomer intended for controlling the permeation of drugs, wherein the elastomer includes 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units. The invention relates also to a method for the preparation of a siloxane-based elastomer including 3,3,3,-trifluoropropyl substituents, where the elastomer is intended for controlling the permeation of drugs. In the method either i) a 3,3,3,-trifluoropropyl-substituted vinyl-functional polysiloxane component and a silicon hydride-functional crosslinking agent are crosslinked in the presence of a catalyst, or ii) a 3,3,3,-trifluoropropyl-substituted polysiloxane component is crosslinked in the presence of a peroxide catalyst.

The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially a progestin or an estrogen, over a prolonged period of time, said device including a core which contains the therapeutically active agent, and a membrane encasing the core wherein said membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer which includes 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units.

The present invention provides positioning mechanisms for devices that cause conduction blocks or ablation in desired areas of tissue. The positioning mechanisms allow for variable geometry of the target sites and enable more accurate therapy at the tissue site.

The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and / or irregular endometrial bleeding over a prolonged period of time.

A delivery system including at least one core and a membrane. The core and the membrane include an elastomer composition containing, e.g., poly(dimethylsiloxane), a siloxane-based elastomer having 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units and / or poly(alkylene oxide) groups, present as alkoxy-terminated grafts or blocks linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms. The delivery system is preferably an implant or an interuterine, intracervical or intravaginal system.

A method for reducing mitral regurgitation includes deploying deforming matter into a selected one of (i) a mitral valve annulus adjacent a posterior leaflet, and (ii) tissue adjacent the mitral valve annulus and proximate the posterior leaflet, to cause conformational change in the mitral valve annulus to increase mitral valve leaflet coaptation.

A rail stent-graft with increased longitudinal flexibility and sealing properties that is deployable within a body lumen, such as the aorta, for repairing an aneurysm. The rail stent-graft includes an anchoring assembly for securing the rail stent-graft to a portion of the vessel above a junction with another vessel.

The invention provides a double-layer sandwich or multi-layer sandwich multi-latex condom and a preparation method thereof. The preparation method of the condom comprises the following steps: vulcanizing natural latex; emulsifying and dispersing polymer materials such as polyurethane or polyisoprene or butyronitrile or other non-natural latex and making the polymer materials into synthetic latex; and dipping a condom die in the natural latex and the synthetic latex respectively and then drying to finally obtain the double-layer sandwich or multi-layer sandwich multi-latex condom the middle layer of which is made from the natural latex or the synthetic latex, wherein, the innermost layer and the outermost layer of the condom can be made from the same material or different materials. The double-layer sandwich or multi-layer sandwich multi-latex condom of the invention has stretch rate and comfortability of the natural latex as well as high compactness of the synthetic latex, thus being applicable to obstructing penetration of small molecules such as hepatitis, AIDS virus and the like.

The present invention provides positioning mechanisms for devices that cause conduction blocks or ablation in desired areas of tissue. The positioning mechanisms allow for variable geometry of the target sites and enable more accurate therapy at the tissue site.

One embodiment of the invention provides a dental cement composition which includes (a) an acid group-having polymerizable monomer, (b) a polyalkenoic acid, (c) an ion-leachable glass filler, (d) a polymerizable monomer not having an acid group, (e) water, (f) a peroxide, (g) a salt of an aromatic sulfinic acid, and (h) an aromatic secondary amine and / or an aromatic tertiary amine.

Damage indicating packaging is disclosed. A damage indicating material may be applied between inner and outer wrapper layers. When the damage indicating material is exposed to oxygen, excessive heat and / or excessive pressure, the material changes in appearance to thereby alert the user that the package may be compromised. The damage indicating material may include an anti-counterfeiting taggant material. Active and intelligent tamper-evident packaging is thus provided.

The invention provides a condom with a natural antibacterial hydrophilic lubrication coating, which is characterized in that the main hydrophilic components are a polymer or a copolymer formed by one or more monomers of polyacrylamide, polyethylene glycol, polyvinylpyrrolidone, carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl methyl cellulose; and chitosan, a plant extract with antibacterial action and a mixture of the chitosan and the plant extract are added to the hydrophilic lubrication coating. The condom spontaneously generates the lubrication action when meeting the moisten environment of the vagina in the course of the sexual life, and simultaneously absorbs and inhabits the microorganisms of the vagina so as to clean the vagina.

The present invention is directed to a means for storing condoms that will protect and conceal the packaged condoms while they are carried on the person or stored by the consumer subsequent to purchase but prior to use. According to the present invention, the storage means, or condom card, comprises two separable half portions each containing a storage compartment for storing at least one condom therein. The two halves of the condom card are separably attached together by known means in the art, such as juxtaposed tabs and slots.

The present invention is directed to a means for storing condoms that will protect and conceal the packaged condoms while they are carried on the person or stored by the consumer subsequent to purchase but prior to use. According to the present invention, the storage means, or condom card, comprises two separable half portions each containing a storage compartment for storing at least one condom therein. The two halves of the condom card are separably attached together by known means in the art, such as juxtaposed tabs and slots.

The present disclosure provides methods and compositions comprising a autophagy inhibitors. Also provided herein are autophagy inhibitors for use as a contraceptive device. Also provided are autophagy inhibitors delivered by an intrauterine delivery system (IUS) to prevent pregnancy or provide contraception. Also provided herein are newly identified compositions for use as autophagy inhibitors.

An electronic capsule (200) features a reservoir (204), and is configured for placement within a reproductive organ, such as the uterus or cervix. While located therein, the capsule dispenses (208), from the reservoir, a substance, such as a reproductive hormone, semen, acidic buffer, fertility drug or other drug, effectively administered from within the organ. In some embodiments, the capsule has on-board sensors(238, 244), and control circuitry in wireless communication with an external processor functioning automatically or guided by a clinician or user, for decisions and timing in administering the substance.

Described is a process for reducing the antigenicity of sap and products made from the sap of the Hevea brasilisensis plant and other rubber plants. The process involves contacting sap or a latex rubber product with a mono or dialdehyde, a semialdehyde or any chemical containing an aldehyde group, to cross-link antigenic proteins within the sap or the latex product. The cross-linked proteins no longer have the capability to cause an allergic reaction to persons coming into contact with the latex products made by the process of the invention. The cross-linking reaction between the proteins in the latex sap and the aldehyde can take place in the solution used to the final product, or after the final latex product has been formed, or during various intermediate steps of the processes for forming the latex products.

Damage indicating packaging is disclosed. A damage indicating material may be applied between inner and outer wrapper layers. When the damage indicating material is exposed to oxygen, excessive heat and / or excessive pressure, the material changes in appearance to thereby alert the user that the package may be compromised. The damage indicating material may include an anti-counterfeiting taggant material. Active and intelligent tamper-evident packaging is thus provided.

An electronic capsule (200) features a reservoir (204), and is configured for placement within a reproductive organ, such as the uterus or cervix. While located therein, the capsule dispenses (208), from the reservoir, a substance, such as a reproductive hormone, semen, acidic buffer, fertility drug or other drug, effectively administered from within the organ. In some embodiments, the capsule has on-board sensors (238, 244) and control circuitry in wireless communication with an external processor functioning automatically or guided by a clinician or user, for decisions and timing in administering the sub stance.

A method and apparatus are provided for fitting a condom-style catheter to a penis of a user. The apparatus includes at least two jaw members movable towards and away from each other. The jaw members, in a first position relative to each other, surround a first portion of the catheter and retain against external surfaces of the jaws a toroidal roll formed of a rolled-up open-ended end sheath portion of the catheter adjoining the first portion. The jaw members are then moved outwardly to a second position relative to each other so that an opening bounded by a wall of the first portion of said catheter between the jaws is shaped and opened up sufficiently to admit placement of an end of a penis therein. The jaws can then be moved inwardly to a position in which the catheter is located on the penis and the toroidal roll can be unrolled from the jaws and thereafter along said penis by a user, so that the penis is located within the catheter. A device for rolling up the sheath portion of the catheter into a toroidal roll is also provided either separately or as part of the above apparatus. This device has movable arms which are inserted into the sheath portion of the catheter and spread apart, so that rolling the sheath portion off the spread arms causes rolling up of the sheath portion into a toroidal roll.

The invention provides an elastic membrane, and a preparation method and application thereof. The elastic membrane comprises a silicone rubber and a medicine. The medicine is coated inside the silicone rubber in a mode of a medicine storage area, and the medicine comprises estrogen. The elastic membrane achieves an efficient therapeutic effect through micro-release of the medicine, and the medicine release is more stable. The elastic membrane has a longer medicine release cycle and better slow release capacity and is used for treatment of uterine cavity damage in a medicine slow-release system. The method for preparing the elastic membrane is simple, raw materials are easy to obtain, the price is low, and industrial large-scale production application is facilitated.