Application of LncRNA RET in regulating and controlling radiosensitivity of tumor cells

A tumor cell, tumor cell apoptosis technology, applied in the application field of LncRNARET regulating tumor cell radiosensitivity, can solve the problem of unclear role and functional mechanism
CN109010831AActive Publication Date: 2018-12-18ACADEMY OF MILITARY MEDICAL SCI
0 Cites 3 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ACADEMY OF MILITARY MEDICAL SCI
Publication Date
2018-12-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses an application of LncRNA RET in regulating and controlling the radiosensitivity of tumor cells. The invention provides an application of RET-related biomaterials in preparationof products for regulating and controlling the radiosensitivity of the tumor cells; the RET-related biomaterials are RET or substances capable of promoting / inhibiting RET expression. With downregulation of RET expression, the growth of the tumor cells under radiation pressure can be inhibited and the radiosensitivity of the tumor cells can be increased; a possible mechanism comprises promotion oftumor cell apoptosis induced by radiation, reduction of the DNA damage repair caused by radiation, and reversion of epithelial mesenchymal cell transformation induced by radiation. RET regulates andcontrols the radiosensitivity of the tumor cells by regulating PTEN. Under radiation pressure, PTEN can reverse the tumor cell growth, apoptosis increasing, DNA damage repair and EMT generation induced by RET silencing, thereby regulating the tumor cell radiosensitivity induced by RET.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to the application of LncRNA RET in regulating radiosensitivity of tumor cells. Background technique

[0002] Genome-wide transcriptome studies have shown that there are a large number of non-coding RNAs (ncRNAs). Non-coding RNAs (non-coding RNAs, ncRNAs) refer to RNA molecules that are not translated into proteins in the transcriptome, including microRNAs (microRNAs, miRNAs), Small nuclear RNA (snRNA), nucleolar small RNA (small nucleolarRNAs, snoRNA), interfering small RNA (small interfering RNA, siRNA), RNA interacting with piwi protein (piwi-interacting RNA, piRNA) etc., long non-coding RNA (long non-codingRNA, LncRNA) and so on. Recent studies estimate that the number of lncRNAs in the human body is about 15,000, and the expression patterns of most lncRNAs are found to be tissue-specific. According to the location and characteristics of LncRNA, it can be divided into five types: ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More