Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound having radiosensitization function and application of compound

A technology of radiation sensitization and radiation sensitizer, which is applied in the field of compounds with radiation sensitization, and can solve problems such as failure of tumor radiotherapy and radiation tolerance of tumor cells

Active Publication Date: 2016-10-26
ZHEJIANG CANCER HOSPITAL
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the current radiotherapy technology continues to develop, the probability of tumor radiotherapy failure is still high, mainly due to the existence of radiation resistance of tumor cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound having radiosensitization function and application of compound
  • Compound having radiosensitization function and application of compound
  • Compound having radiosensitization function and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] The embodiments of the present invention will be described in detail below in conjunction with the drawings and specific examples. It should be understood that these examples are only used to illustrate the present invention and should not be regarded as limiting the scope of the present invention.

[0033] For those who do not indicate specific techniques or conditions in the following examples, the procedures shall be carried out in accordance with the techniques or conditions described in the literature in the field or in accordance with the product specification. The reagents or instruments used without the manufacturer's indication are all conventional products that can be purchased on the market.

[0034] 1. Material description

[0035] Dimethyl sulfoxide (DMSO), RPMI-1640 medium and fetal bovine serum were purchased from GIBCO. 0.25% trypsin and 0.02% disodium diethylenetetraacetate (EDTA) were purchased from GIBCO. The cell cycle ABC kit is a product of Becton, Dic...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
control rateaaaaaaaaaa
control rateaaaaaaaaaa
Login to View More

Abstract

The invention discloses a compound having a radiosensitization function and an application of the compound. The compound has an anti-proliferation effect on p53 wild tumor cells and p53 mutant tumor cells and can reduce TG2 gene expression of two kinds of cells while no remarkable change occurs to p53 gene expression. The compound and IR are subjected to combined treatment, two kinds of cells have remarkable cell apoptosis increasing and remarkable cell cycle arresting, the radiosensitivity is remarkably improved, and the TG2 gene expression is remarkably reduced. Therefore, the compound has a remarkable radiosensitization function on the p53 wild tumor cells and the p53 mutant tumor cells and is expected to substantially improve the tumor radiotherapy effect after being applied to tumor radiotherapy as an active ingredient of a radiosensitizer and particularly applied to p53 signal path activation enhanced tumor radiotherapy after excessive activation of a p53 signal path and ionizing radiation induction.

Description

Technical field [0001] The invention belongs to the fields of biomedicine and pharmacy, and specifically relates to a compound with radiosensitization effect and its application. Background technique [0002] Cancer is a major health problem all over the world. Lung cancer is the most common malignant tumor, its incidence is 12.4% of the tumor incidence, and the mortality rate is as high as 17.8%. In China, the smoking behavior that easily leads to lung cancer has not been effectively controlled, and coupled with the environmental deterioration factors in recent years, the incidence and death of lung cancer have shown an upward trend year by year. [0003] Radiotherapy is one of the conventional treatments for cancer, and the same is true for lung cancer. Although the current radiotherapy technology continues to develop, the probability of tumor radiotherapy failure is still high, the main reason is the existence of tumor cell radiation tolerance. Therefore, radiosensitivity is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D261/04A61P35/00
CPCC07D261/04
Inventor 陈明冯建国
Owner ZHEJIANG CANCER HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com