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Water gel wound dressing containing radiation sensitive agent and preparing method

A wound dressing and hydrogel technology, which is applied in the preparation of industrialized production operations, and in the field of hydrogel wound dressings, can solve the problems of unfavorable technical industrial production, difficulty in applying for and setting up equipment, and high equipment requirements, so as to promote wound healing and reduce the risk of injury. The formation of small scars, the effect of simplification of the process

Inactive Publication Date: 2005-05-18
杭州拜康医用产品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current method of preparing hydrogel wound dressings is mainly to perform physical cross-linking through repeated freezing. This method generally requires 3-5 repeated freezing, and requires the lowest freezing temperature to reach -20°C. Not only is the process cumbersome, Moreover, the requirements for equipment are also very high.
There is also chemical crosslinking by electron beam or cobalt 60 source irradiation, but the current method is to directly irradiate the dissolved polymer solution, which requires the production unit to have irradiation equipment, but this equipment It is very difficult to apply for establishment, so it is not conducive to the industrial production of technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0014] Example 1 Dissolve 24g of polyvinyl alcohol in 188g of hot water at 95°C. After dissolving completely, cool the solution to 60°C, add 180g of polyvinylpyrrolidone, 4g of sodium carboxymethylcellulose, 4g of polyethylene glycol, and 4g of 1% The triethanolamine solution, stirred evenly and fully dissolved, vacuumed and degassed, after degassing, the polymer aqueous solution was poured on the non-woven fabric on the film coating machine, freeze-solidified and formed, covered with release paper, cut and packaged, and used cobalt 60 Irradiated, the dose is 35kGy, and the cross-linking degree of the product is 32%.

example 2

[0015] Example 2 Dissolve 160g of polyvinyl alcohol in 212g of hot water at 90°C. After dissolving completely, cool the solution to 50°C, add 4g of polyvinylpyrrolidone, 8g of solid aloe extract, 8g of glycerin, and 1% sodium dihydrogen phosphate 8g of the solution was stirred evenly and fully dissolved, vacuumed for degassing, after degassing, the polymer aqueous solution was poured on the non-woven fabric on the film coating machine, freeze-solidified and formed, covered with release paper, cut and packaged, irradiated with cobalt 60, The dosage is 30kGy, and the cross-linking degree of the product is 45%.

example 3

[0016] Example 3 Dissolve 32g of polyvinyl alcohol in 280g of hot water at 100°C. After complete dissolution, cool the solution to 70°C, add 16g of polyvinylpyrrolidone, 40g of sodium alginate, 20g of glycerin, and 12g of 1% sodium dihydrogen phosphate solution Stir evenly, stir evenly and fully dissolve, vacuumize and defoam, after defoaming, pour the polymer aqueous solution on the non-woven fabric on the film coating machine, freeze and solidify, cover with release paper, cut and package, and irradiate with cobalt 60 , the dosage is 35kGy, and the cross-linking degree of the product is 42%.

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PUM

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Abstract

The aquogel wound dressing containing radiosensitizer has aquogel comprising PVP, PVA, radiosensitizer, plasticizer, pH regulator, water, etc. The components of PVP, PVA, radiosensitizer, plasticizer and pH regulator are dissolved in water to prepare polymer aqua; the aqua is defoamed, poured onto non-woven fabric, frozen to cure and covered with stripping paper; and through cutting, radiating with Co-60 light source in the dosage of 15-65 kGy for chemical reaction and sterilization, the aquogel wound dressing is prepared. The aquogel wound dressing consists of three layers, including aquogel, non-woven fabric and stripping paper. It is suitable for use in protecting and treating wound of burns, scalds, ulcer, cutting, etc.

Description

technical field [0001] The invention relates to a wound dressing, in particular to a hydrogel wound dressing containing a radiation sensitive agent, and to a preparation method for the industrial production operation of the wound dressing. technical background [0002] Wound dressings have developed greatly in recent decades, and many new types of dressings have appeared, especially wound dressings with biomedical polymer materials as the main components have attracted more and more attention. This new type of dressing has various forms: film type, foam type, hydrocolloid type, hydrogel type (paste or film), alginate type, etc. These products have their own characteristics and are suitable for one or more types of wounds such as scalds, burns, chemical corrosion, various ulcers, scratches, cuts, lacerations, and surgical injuries. [0003] Membrane-shaped hydrogel wound dressing is one of the special wound dressings. It has almost all the properties of an ideal dressing, su...

Claims

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Application Information

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IPC IPC(8): A61L15/24
Inventor 王雪亮郭冬梅方国芳赵栋芳徐文娟
Owner 杭州拜康医用产品有限公司
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