Cell nucleus targeted radiosensitizer and preparation method thereof
A technology of cell nuclei and sensitizers, applied in the field of nano-biomedicine, can solve the problems of single imaging mode, low efficiency of targeted transport, lack of synergy, etc., and achieve high imaging sensitivity and spatial resolution, good diagnosis and treatment efficiency, and high-efficiency The effect of synergistic treatment
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[0055] First, refer to figure 1 with image 3 The preparation method of core / shell cavity mesoporous silica structure (RUMSNs) is described. The preparation of the core / shell cavity mesoporous silica structure mainly includes: the preparation of the inner core gadolinium-doped upconversion luminescent nanoparticle core, the wrapping of the mesoporous silica shell, and the formation of the cavity between the inner core and the outer shell. The formation of the cavity can be achieved by two methods: introducing a solid silicon oxide layer between the inner core and the mesoporous silicon oxide shell and then etching it away (see figure 1 Steps 1, 2, 3); or directly form a mesoporous silica shell on the outer surface of the core and etch away part of the mesoporous silica on the inner side (see figure 1 Steps 4, 5, and 6). An example of the preparation of core / shell cavity mesoporous silica structures (RUMSNs) is specifically described below.
[0056] (1) Preparation of core gadolin...
Embodiment 1
[0068] Example 1 Preparation of gadolinium-doped up-conversion fluorescent nanoparticles UCNPs
[0069] 1. Preparation of rare earth chlorides. Weigh 1.28mmol (388.3008mg) YCl respectively 3 -6H 2 O, 0.36mmol (139.4964mg) YbCl 3 -6H 2 O, 0.04mmol (15.2684mg) ErCl 3 -6H 2 O, 0.02mmol (5.5087mg) TmCl 3 , 0.3mmol (79.083mg) GdCl 3 -6H 2 O. These powders are placed in the same sample bottle, then dissolved in 4mL deionized water, and transferred to a 100mL three-necked flask;
[0070] 2. Add 15 mL of oleic acid and 30 mL of octadecene to a three-necked flask, and stir at room temperature for 1 hour. Then argon gas was passed for 5 minutes to remove the air in the bottle, and the system began to slowly remove water. Raise the temperature to 80 degrees and keep it for 1 hour or longer (removing free water); then raise it to 120 degrees and keep it for 1 hour; then raise it to about 156 degrees and keep it for 1 hour to obtain a yellow clear liquid. Stop heating and let the system cool...
Embodiment 2
[0075] Example 2 The outer surface of UCNPs is coated with solid silicon oxide UCNPsSiO 2
[0076] The inverse microemulsion method is adopted to realize the encapsulation of solid silica. Add 1 mL of NP-5 to 20 mL of cyclohexane and stir magnetically for 40 minutes. 1.5mL 100mM UCNPs cyclohexane solution was added to the NP-5 / cyclohexane system, colorless and transparent, sealed and stirred for 3h. 0.14 mL 30% ammonia water was added dropwise to the mixed solution, and sealed and stirred for 2 hours. 0.16mL TEOS was dissolved in 1ml cyclohexane and introduced into the system at a rate of 1mL / h. After 36 hours, methanol was added to destroy the inverse microemulsion system. After stirring for 30 minutes, the mixture was collected by centrifugation. The whole process was washed with ethanol and dispersed by ultrasound, repeated three times, and finally dispersed in 5 mL of deionized water. See the TEM image of the product Figure 4 In (b 2 ).
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