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45 results about "Targeted Radiotherapy" patented technology
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Targeted radiation is meant to deliver a higher dose of radiation to the cancer without causing so much damage to surrounding tissues. Targeted radiation therapy is in use to treat prostate cancer and is under study with other types of cancer including lung cancer, brain tumors and cancer of the head and neck.
Composite nanoparticle for sensitizing tumor radiotherapy and preparation method and application of composite nanoparticle
ActiveCN109771442AGood dispersionGood biocompatibilityPowder deliveryInorganic active ingredientsRadiation DosagesUltrafiltration
The invention discloses a composite nanoparticle for sensitizing tumor radiotherapy and a preparation method and application of the composite nanoparticle. The composite nanoparticle comprises proteinand bismuth selenide and manganese dioxide which grow on the protein. The preparation method comprises the steps that a manganese salt solution is added into a aqueous dispersion of bismuth selenide-protein nanoparticles, after uniform mixing is carried out, a strong alkaline solution is added, the pH value is adjusted to alkaline, a heating temperature control reaction is carried out, ultrafiltration and washing are carried out, and the composite nanoparticle is obtained. The composite nanoparticle has the advantages that the water dispersibility and biocompatibility are good, radiotherapy is sensitized by increasing the local radiation dosage through bismuth selenide and improving tumor hypoxia through manganese dioxide, and computed tomography, magnetic resonance and photoacoustic multimode imaging angiography can be achieved simultaneously; the preparation method of the composite nanoparticle is simple, convenient and practical, the condition is mild, the controllability is good,and the implementation and promotion are easy; the composite nanoparticle can achieve the integration of targeted radiotherapy sensitization, diagnosis and treatment of the tumor, and has a broad application prospect in the fields of nano-medicine, disease diagnosis, tumor treatment and the like.
Owner:HUAZHONG UNIV OF SCI & TECH
Tracking of tumor location for targeted radiation treatment
ActiveUS20130023715A1Reduce the amount requiredAccurate measurementX-ray/gamma-ray/particle-irradiation therapyBeam trajectoryLight beam
Systems, methods, and apparatuses are provided for targeting diseased tissue with a radiation beam. Functional models can be used to accurately obtain a location of specific tissue using sensors at identifiable locations of the patient's body. Using the relative distances between the identifiable sensor locations can allow a patient to be in various positions. The functional models can be prepared using accurate pre-treatment scans, which can be taken at various body positions (e.g., rotations and / or translations). The trajectory of the beam can be measured efficiently and accurately using beam sensors attached to a beam assembly, where a model maps the beam sensor locations to a trajectory of the beam. Further, a motion model can use measurements made during treatment to obtain a time-dependent functions of the movement of the specific tissue, the change of an optimal beam trajectory over time, or the change in input commands to a beam positioner.
Owner:HEADWATER PARTNERS I
Targeted radiation treatment using a spectrally selective radiation emitter
InactiveUS20050242301A1Minimum energy lossEfficient productionX-ray/infra-red processesFood preservationOptical coatingLength wave
Radiation from a spectrally broad radiation source is reduced to radiation of limited spectral range with high efficiency by an emitter that includes a radiation source and a multilayer optical coating that reflects radiation of certain wavelengths back toward the source, allowing other wavelengths to pass. The multilayer optical coating provides a high efficiency reflectance, thereby minimizing loss of radiation energy despite limiting the escaping energy to one or more narrow selected wavelength bands. The resulting radiation is useful in treating a host to destroy or deactivate undesirable pathogens, cells, or tissues.
Owner:ADVANCED LIGHT TECH
Location mark based radiotherapy positioning method
ActiveCN110227214AImprove calculation accuracyPrecise positioningX-ray/gamma-ray/particle-irradiation therapyPositioning systemTargeted Radiotherapy
The invention provides a location mark based radiotherapy positioning method. The method includes the following steps: a step of a radiotherapy planning phase, namely the step of determining locationmark pasting points at the periphery of a target radiotherapy target area, respectively pasting a first location mark at each location mark pasting point, adopting a CT system to scan a target radiotherapy object, and removing the first location marks after obtaining the target radiotherapy object CT images of mark points with the first location marks; and a step of a radiotherapy implementation phase, namely the step of respectively pasting a second location mark at each location mark pasting point, adopting an image guiding and positioning system to scan the target radiotherapy object, obtaining the target radiotherapy object guiding and positioning images of the mark points with the second location marks, performing registration on the target radiotherapy object CT images and the targetradiotherapy object guiding and positioning images based on the mark points of the first location marks and the mark points of the second location marks so that the positioning deviation of patientscan be obtained, and adjusting the positioning of the patients based on the positioning deviation. Thus, the accurate registration positioning of the target radiotherapy object guiding and positioningimages and the target radiotherapy object CT images during radiotherapy can be realized.
Owner:江苏瑞尔医疗科技有限公司
Screening for CXCR4 receptor antagonism polypeptides for treating breast carcinoma and its uses
InactiveCN101334411AAbility to block transferHigh specific binding activityPeptide/protein ingredientsBiological testingLymphatic SpreadBinding site
The invention provides a screening and modification method, a marker and an application of polypeptide drugs which are used in the treatment of CXCR4 receptor-mediated breast cancer. A human chemokine SDF-1 Alpha and the homology region of a human herpes virus 8 MIP-II are compared, thereby obtaining a binding site of vMIP-II and CXCR4 receptor and further obtaining a CXCR4 specific binding active peptide. With the role of specific binding CXCR4 and the blocking of the physiological binding of the SDF-1 Alpha and the CXCR4, the CXCR4 specific binding active peptide is a high-efficient and specific chemokine receptor antagonist. The chemotactic activity of wide type SDF-1 Alpha to breast cancer cells and the growth of the breast cancer cells can be inhibited, and the growth and the metastasis of the CXCR4-positive tumor cells are simultaneously inhibited, thereby having the dual-target effect. The invention further provides a marked polypeptide to be targetedly positioned in sentinel lymph node and metastatic site, thereby being used in the detection and the targeted radiotherapy of the metastatic status of the sentinel lymph node before and in the operation of the breast cancer.
Owner:BENGBU MEDICAL COLLEGE
Immunogenic Treatment Of Cancer
ActiveUS20190224294A1Safe and well-tolerated and effective methodCombination is synergisticBacterial antigen ingredientsBacteria material medical ingredientsRadiofrequency ablationRadiation exposure
The present invention provides an immunomodulator for use in the treatment and / or control of a neoplastic disease in a patient intended to undergo immunogenic cell death therapy simultaneously, separately or sequentially with administration of the immunomodulator. The therapy can be selected from microwave irradiation, targeted radiotherapy, embolization, cryotherapy, ultrasound, high intensity focused ultrasound, cyberknife, hyperthermia, radiofrequency ablation, cryoablation, electrotome heating, hot water injection, alcohol injection, embolization, radiation exposure, photodynamic therapy, laser beam irradiation, and combinations thereof.
Owner:IMMODULON THERAPEUTICS
Immunogenic Treatment Of Cancer
InactiveUS20140356397A1Bacterial antigen ingredientsElectrotherapyRadiofrequency ablationRadiation exposure
Owner:IMMODULON THERAPEUTICS
Radiotherapy plan generation system and device and storage medium
ActiveCN110931107AImprove optimization efficiencyAvoid the process of repeatedly manually adjusting constraintsMechanical/radiation/invasive therapiesInternal combustion piston enginesIndustrial engineeringTargeted Radiotherapy
The embodiment of the invention discloses a radiotherapy plan generation system and device and a storage medium. The system comprises a memory, a processor and a computer program which is stored on the memory and can run on the processor. When the processor executes the program, the following steps are implemented: determining a plurality of current constraint points according to a pre-plan imageand a radiotherapy prescription; if each current constraint point does not meet a first preset convergence condition, determining a current candidate constraint point corresponding to the target constraint point from the current constraint points, and completing movement of each current constraint point based on the current candidate constraint point so as to iteratively update each current constraint point until each updated current constraint point meets the first preset convergence condition; and taking the updated current candidate constraint point as a target constraint point, and generating a target radiotherapy plan according to the target constraint point. Through the technical scheme, the optimization efficiency of the radiotherapy plan is improved.
Owner:SHANGHAI UNITED IMAGING HEALTHCARE
Radiotherapy plan generation equipment, radiotherapy plan generation device and storage medium
PendingCN111128340AImprove production efficiencyImprove accuracyMedical simulationMechanical/radiation/invasive therapiesNetwork modelExecution control
The invention discloses radiotherapy plan generation equipment, a radiotherapy plan generation device and a storage medium. The equipment comprises one or more processors; and a memory for storing oneor more programs. When one or more programs are executed by one or more processors, the one or more processors realize the following operations: inputting image information and prescription dose information into a preset neural network model to obtain a current operation instruction; controlling a radiotherapy plan module to generate a current radiotherapy plan according to the current operationinstruction; if the current radiotherapy plan does not meet a preset cycle end condition, feeding back the current score corresponding to the current radiotherapy plan to a preset neural network modelto update the output current operation instruction, and returning to execute the operation of controlling the radiotherapy plan generation module; and if the current radiotherapy plan satisfies the preset cycle end condition, determining the current radiotherapy plan as a target radiotherapy plan so as to improve plan generation efficiency and plan generation accuracy.
Owner:SHANGHAI UNITED IMAGING HEALTHCARE
Therapy for glioblastoma multiforme
ActiveUS10773098B2Efficient killingReduce chanceOrganic active ingredientsUltrasound therapyAmino-Levulinic AcidNanocarriers
The invention provides a therapy method for glioblastoma multiforme (GBM). The therapy method uses a low-dose radiation to realize GBM tumor cell-targeted radiotherapy via sequentially administration of radiation enhancer-incorporated nanocarriers, 5-aminolevulinic acid, therapeutic ultrasound and therapeutic radiation.
Owner:NATIONAL YANG MING UNIVERSITY
Therapy for glioblastoma multiforme
ActiveUS20180207447A1Efficient killingReduce chanceOrganic active ingredientsUltrasound therapyAmino-Levulinic AcidNanocarriers
The invention provides a therapy method for glioblastoma multiforme (GBM). The therapy method uses a low-dose radiation to realize GBM tumor cell-targeted radiotherapy via sequentially administration of radiation enhancer-incorporated nanocarriers, 5-aminolevulinic acid, therapeutic ultrasound and therapeutic radiation.
Owner:NATIONAL YANG MING UNIVERSITY
Radiotherapy plan determination method and device, storage medium and processor
PendingCN114446440AReduce workloadAvoid hand sketchingImage enhancementImage analysisAdaptive radiotherapyNuclear medicine
The invention discloses a radiotherapy plan determination method and device, a storage medium and a processor. The method comprises the steps of shooting a first medical image for making a reference plan for a target patient, and performing region-of-interest sketching on the first medical image to obtain a first sketching result; generating a radiotherapy plan according to the sketching result I to obtain a reference plan; checking the reference plan, shooting a second medical image for the target patient under the condition that the reference plan passes the checking, and registering the second medical image with the first medical image to obtain a registration result; in the delineation platform, the delineation result I performs region-of-interest delineation on the medical image II based on the registration result to obtain a delineation result II; and determining a target radiotherapy plan according to the sketching result 2 and the reference plan. According to the invention, the problem that the design of the adaptive radiotherapy plan is too time-consuming in the prior art is solved.
Owner:MANTEIA TECH CO LTD
Micromolecule lung cancer targeted radioactive therapeutic agent and preparation method thereof
InactiveCN102641511AImprove stabilityImprove featuresRadioactive preparation carriersAntineoplastic agentsParanasal Sinus CarcinomaOncology
The invention discloses a micromolecule lung cancer targeted radioactive therapeutic agent. Isotope 131I is marked with eight-peptide molecules with XGXG structures, wherein G shows L glycine, and X shows optional one of 20 amino acids. The invention further discloses a preparation method of the micromolecule lung cancer targeted radioactive therapeutic agent. The micromolecule lung cancer targeted radioactive therapeutic agent has good stability and biological distribution characteristics, can obviously suppress growth of tumour in a human lung cancer nude mouse animal model body, does not have obvious toxic and side effects to vitals such as livers, kidneys, lungs, hearts and the like, is applicable to targeted therapy for patients suffering from non-small cell lung cancer (squamous carcinoma and glandular cancer), and has an important clinical application value in the aspect of molecule targeted treatment for lung cancer.
Owner:ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
A gamma spectrometer for boron neutron capture therapy irradiation beams
InactiveCN110967727AAccurate measurementGood energy resolutionX-ray spectral distribution measurementShieldingNuclear engineeringHigh energy
The invention belongs to the technical field of binary targeted radiotherapy, in particular to a gamma spectrometer for boron neutron capture therapy irradiation beams, the spectrometer is used for measuring a BNCT irradiation beam, and comprises a gamma shielding cylinder (2) internally provided with a high-purity germanium semiconductor detector (1), a gamma shielding collimator (3) arranged inthe incident end of the gamma shielding cylinder (2), and a first neutron shielding layer (4) and a second neutron shielding layer (5) which are arranged outside the incident end of the gamma shielding cylinder (2), a BNCT irradiation beam sequentially passes through the first neutron shielding layer (4), the second neutron shielding layer (5) and the gamma shielding collimator (3) to irradiate the high-purity germanium semiconductor detector (1). The gamma energy spectrometer has the advantages of high energy resolution, small size, light weight and convenience in operation.
Owner:CHINA INSTITUTE OF ATOMIC ENERGY
Pharmaceutical composition for targeted radiation and immune combined treatment of tumors
ActiveCN113616818APromote infiltrationActivate anti-tumor immune responseRadioactive preparation carriersAntibody ingredientsRadioactive drugT lymphocyte
In particular, the present invention relates to a pharmaceutical composition containing a labeled complex Nu-BFC-A-(L) n-RGD polypeptide as defined in the present invention, an immunotherapeutic drug, and an optional nano antibody molecular imaging probe. The labeled complex provided by the invention is an effective targeted radiotherapy drug, can significantly increase infiltration of CD4 + and CD8 + T lymphocytes (rather than T-reg cells), and can significantly up-regulate PD-L1 expression on the surface of host myeloid immune cells (rather than tumor cells) in tumors. Therefore, the optimal synergistic effect can be obtained by carrying out PD-L1 blocking treatment after targeted radioactive drug delivery treatment. Besides, by applying the PD1 or PD-L1 nano antibody molecular imaging probe, the expression of PD-L1 in the tumor after targeted radiation treatment can be observed, and the method has guiding significance for making a treatment strategy of targeted radiation and immune combined treatment and is beneficial to improving the effect of the combined treatment.
Owner:PEKING UNIV
Application of therapeutic isotope labeled Evans blue and its derivatives in preparing tumor targeted radiotherapy medicaments
InactiveCN102488909AEffective in treating tumorsNon-immunogenicRadioactive preparation carriersAntineoplastic agentsTumor targetTumor therapy
The invention relates to therapeutic isotope labeled Evans blue and its derivatives. The compound contains a chemical element or isotope with an unstable nucleus. During the decay of the compound into a stable state, radiation can be emitted, and the radiation is sufficient to destroy adjacent cells or tissues so as to be used for targeted radiotherapy, thus improving the curability of warm-blooded animals receiving necrosis induced anti-tumor treatment. The invention has a special advantage that after tumor treatment through chemotherapy and physical methods, live edges can be supplemented by therapeutically and radioactively labeled Evans blue in single or multiple doses so as to improve curability. Necrosis induced treatment cases include, for example, minimally invasive tumor ablationconducted by chemical methods like percutaneous ethanol or acetic acid injection, or by physical methods like cryotherapy, microwave, focused ultrasound, interstitial laser therapy and radiofrequencyablation; chemotherapy utilizing cytotoxic drugs or vascular targeting agents (VTA ); as well as external or internal radiotherapy.
Owner:JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
Multi-modal imaging guided radiotherapy method, device and system
PendingCN111325703AAccurate radiotherapySolve the problem of not being able to meet the needs of high-precision radiotherapyImage enhancementImage analysisTreatment effectComputer vision
The embodiment of the invention discloses a multi-modal imaging guided radiotherapy method, device and system. The method comprises the steps that a multi-modal image set of a target radiotherapy partis acquired, and the multi-modal image set comprises at least two images of an absorption image, a phase image and a dark field image; according to the tissue structure type of the target radiotherapy part, performing image fusion on at least two images in the multi-modal image set to obtain a fused image of the target radiotherapy part; and controlling radiotherapy equipment to execute radiotherapy operation according to the fused image and the planned radiotherapy image. According to the embodiment of the invention, the method achieves the fusion of the at least two types of images of the target radiotherapy part, solves a problem that the single imaging cannot meet the high-precision radiotherapy demands, improves the radiotherapy positioning precision, enables the radiotherapy equipment to carry out the precise radiotherapy of the target radiotherapy part, and improves the treatment effect of radiotherapy.
Owner:SHANGHAI UNITED IMAGING HEALTHCARE
PSMA targeted radiotherapy medicine and preparation method thereof
PendingUS20210121585A1Improve the quality of lifeTime can be spentRadioactive preparation carriersAntigenDisease
The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.
Owner:LI MING HSIN +7
Dose determination system and method and computer readable storage medium
The invention relates to a dose determination system, a dose determination method and a computer readable storage medium. The method comprises the following steps of: acquiring a target radiotherapy plan of an object, wherein the target radiotherapy plan comprises sub radiotherapy plans corresponding to a rack angle; based on the sub-radiotherapy plan corresponding to the rack angle, determining a target flux graph corresponding to the rack angle, wherein the target flux graph comprises a plurality of first sub-regions, and each first sub-region corresponds to a first weight value; based on the first weight value corresponding to each first sub-region, determining the number of sampling particles corresponding to each first sub-region; and determining target dose distribution of the object at the rack angle according to a Monte Carlo algorithm on the basis of the number of the sampling particles corresponding to each first sub-region.
Owner:SHANGHAI UNITED IMAGING HEALTHCARE
Methods of protecting vascular integrity induced by targeted radiation therapy
PendingUS20200164039A1Induced erectile dysfunctionPeptide/protein ingredientsPharmaceutical non-active ingredientsThrombopoietin mimeticsPlatelet
Methods of protecting vascular integrity in a subject exposed to a targeted radiation therapy are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as TPOm, is used to protect vascular integrity following the radiation therapy.
Owner:JANSSEN PHARMA NV
Methods of protecting vascular integrity induced by targeted radiation therapy
PendingCN111432845APeptide/protein ingredientsPharmaceutical non-active ingredientsThrombopoietin mimeticsPlatelet
Methods of protecting vascular integrity in a subject exposed to a targeted radiation therapy are described. In particular, an effective amount of a thrombopoietin (TPO) mimetic, such as TPOm, is usedto protect vascular integrity following the radiation therapy.
Owner:JANSSEN PHARMA NV
Using targeted radiotherapy (TRT) to drive Anti-tumor immune response to immunotherapies
PendingCN111565762AProof of validityRapid responseAntibody mimetics/scaffoldsPharmaceutical delivery mechanismImmunomodulating AgentMetal chelate
The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid ether metal chelate, a radiohalogenated phospholipid ether, or other targeted radiotherapy (TRT) agent that is differentially retained within malignant solid tumor tissue, and performing immunotherapy in the subject by systemically administering to the subject an immunostimulatory agent, such as an immune checkpoint inhibitor. In a non-limiting example, the radioactive phospholipid ether metal chelate or radiohalogenatedphospholipid ether has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half-lifeof greater than 6 hours and less than 30 days, or wherein R1 comprises a radioactive halogen isotope. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is -N+(CH3)3.
Owner:WISCONSIN ALUMNI RES FOUND
Clinical target region identification method and device applied to cervical cancer radiotherapy
PendingCN114004813ARealize automatic sketchingImprove efficiencyImage enhancementImage analysisNerve networkRadiology
The invention discloses a clinical target region identification method and device applied to cervical cancer radiotherapy, and the method comprises the steps: obtaining a to-be-identified target image which is a 3D cervical cancer CT image; identifying the target image based on a target segmentation network model to obtain a segmentation result, the target segmentation network model being a neural network model generated by training based on a training sample corresponding to a 3D cervical cancer CT image, and the segmentation result being a to-be-determined radiotherapy clinical target region identified by the target segmentation network model; and based on the segmentation result, determining a cervical cancer target radiotherapy clinical target region. According to the invention, cervical cancer radiotherapy clinical target area sketching is realized based on the target segmentation network model, the efficiency and accuracy of cervical cancer radiotherapy clinical target area automatic sketching are improved, and the labor cost is reduced.
Owner:UNIV OF SCI & TECH OF CHINA
A composite nanoparticle for sensitizing tumor radiotherapy and its preparation method and application
ActiveCN109771442BGood dispersionGood biocompatibilityPowder deliveryInorganic active ingredientsDiseaseRadiation Dosages
Owner:HUAZHONG UNIV OF SCI & TECH
Intelligent processing method for breast cancer lesion pictures
The invention provides a breast cancer lesion picture intelligent processing method, which comprises the following steps: marking existence state information of breast tissues on a breast region reference picture obtained by shooting a preset breast region of a target object for the first time to obtain a breast region reference picture; according to a preset time interval, continuously shooting a preset mammary gland region of the target object to obtain a plurality of mammary gland region tracking pictures, and marking existence state information of mammary gland tissues to obtain a mammary gland region diagnosis picture; and comparing all breast region diagnosis pictures with the breast region reference picture, determining existence state information of a breast cancer focus region, and obtaining breast cancer cell growth and diffusion judgment information, thereby adjusting operation parameters for performing radiotherapy treatment on the target object, and improving radiotherapy treatment efficiency. In this way, the data processing amount of picture analysis and recognition can be reduced, time progressive recognition and judgment can be carried out on the breast cancer lesion condition of the target object, and therefore targeted radiotherapy treatment can be carried out on breast cancer cells.
Owner:SUZHOU HONG XI CONVERGENT MEDICAL AI INC
Radioactive device
InactiveUS20090297437A1Efficient removalPrevent disseminationPowder deliveryNeutron capture therapyMedicineNanostructure
A radioactive or radioactivable nanostructure has a core, the core including at least two atoms, at least one of which being radioactive or radioactivable, and a shell encapsulating the core and selected among a selected material so that at the most, 20% of the radioactive radiation produced by the core are stopped or absorbed by the shell and the manufacturing method thereof.The various uses of such a nanostructure, and more specifically the use thereof in the medical field, and more specifically in targeted radiotherapy are also disclosed.
Owner:UNIV DE NAMUR
Targeted Radiotherapy Chelates for In Situ Immune Modulated Cancer Vaccination
ActiveUS20200330621A1Maintain good propertiesClean emission profilePeptide/protein ingredientsPharmaceutical delivery mechanismVaccinationImmunomodulating Agent
The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula:wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.
Owner:WISCONSIN ALUMNI RES FOUND
Method for self-adaptive target area of radiotherapy system and radiotherapy system thereof
The invention discloses a radiotherapy system self-adaptive target area method and the radiotherapy system thereof. The radiotherapy system self-adaptive target area method includes obtaining the position change amount of the target area identification position; collecting the current time of the target area identification position the direction of movement; read the position change amount of the movement direction at the current time in the database; and control the radiation therapy device to move in the direction opposite to the movement direction at the current time. The radiotherapy system includes, for acquiring the position change amount of the target region identification position; a movement direction acquisition device for acquiring the movement direction of the target region identification position at the current time; for reading the position change of the movement direction at the current time in the database A processing device that issues an instruction to the radiation therapy device to move in a direction opposite to the current time motion direction; and a radiation therapy device that is used to move in a direction opposite to the current time motion direction according to the command issued by the processing device.
Owner:THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
Cervical cancer internal radiation therapy device
The invention discloses a cervical cancer internal irradiation treatment device which comprises a cervical canal source applicator, a uterine orifice lip source applicator, a rotating mechanism, a perspective locating machine, and an after-loading control cabinet. The invention aims to provide a cervical cancer internal irradiation treatment device which has a novel structure, is safe and has programmed and target control functions. For cervical cancer treatment in hospitals nowadays, fixed-pattern programmed control is adopted, which poses harm to the human body. A two-hemisphere lateral adjustment source applicator is adopted in radiotherapy of uterine orifice lip, which has the defect of limited radiotherapy radiation surface. Thus, improvement is made on the treatment mode and device of cervical cancer. The technical key points are as follows: an iridium source cavity and the rotating mechanism are arranged to implement rotating radiotherapy of uterine orifice lip, programmed radiotherapy is implemented for patients with severe cervical cancer, and clinical dynamic inching target radiotherapy is implemented using the perspective locating machine for patients with mild cervical cancer, thus overcoming the shortcomings of the prior art and achieving the purpose of curative effect improving. The cervical cancer internal irradiation treatment device is applicable to clinical application of internal irradiation therapy of patients with cervical cancer.
Owner:宋玲琴
Automatic sketching method and device for lumbosacral nerve roots and storage medium
PendingCN114796901AOut of shapeAvoid damageImage enhancementImage analysisComputer visionNuclear medicine
The invention discloses an automatic sketching method and device for lumbosacral nerve roots and a storage medium, and relates to the stereotactic body radiotherapy technology, and the method comprises the steps: obtaining a plurality of belly and pelvic CT images, obtained in a CT examination mode, of target radiotherapy patients from a database, and taking the belly and pelvic CT images as first images; images with clear lumbosacral nerve root deformation of the multiple target radiotherapy patients obtained in other examination modes are obtained from the database and serve as second images; correcting the first image by using the second image to obtain a CT image with clear lumbosacral nerve root deformation, and taking the CT image as a third image; an abdominal and pelvic CT image, obtained in a CT examination mode, of the patient to be subjected to radiotherapy is obtained and serves as a fourth image; and processing the fourth image of the patient to be subjected to radiotherapy by using an automatic sketching model obtained by training the first image and the third image to obtain a sketched lumbosacral nerve root deformation CT image of the patient to be subjected to radiotherapy. According to the method, the defects that the consistency is poor and learning is difficult when the lumbosacral nerve root deformation is artificially sketched on the CT plain scanning image can be overcome, the nerve root deformation is clearer compared with that of CT imaging, and the price and the requirement are lower compared with that of MRI imaging.
Owner:PEKING UNIV FIRST HOSPITAL
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