The invention discloses an acute respiratory failure treatment medicine and a preparation method thereof, and belongs to the field of traditional Chinese medicines. Effective components of the medicine comprise Salvia miltiorrhiza, benzoin, Rhizome of Medical Angiopteris, flower of official magnolia, Micromeria biflora benth, vine of Stelmatocrypton khasianum (Benth.) H. Baill, Herba Houttuyniae, Radix et Rhizoma Nardostachyos, Herba Canscorae Lucidissimmae and Radix Scutellariae. The medicine has the efficacy of clearing heat, detoxifying, inducing resuscitation, tranquilizing mind, warming the middle warmer, moving qi and loosening the center, is convenient to use, can be used for treating acute respiratory failure induced expiratory dyspnea, dysphoria, convulsion coma and other clinic symptoms, can realize simultaneous treatment of principal and subordinate symptoms, has substantial curative effects, and can avoid complication initiation; and the medicine has the advantages of reasonable composition, good absorption effect, no untoward or toxic or side effects, no dependence, short treatment course, high cure rate, no long-time taking, no drug resistance, and facilitation of rapid health recovery of patients.