511 results about "Medicine field" patented technology

The present invention belongs to the field of medical instrument structure design technology. The endoscopic optical tomographic imaging scanning probe device based on micro motor includes transparent jacket, light guide unit and transverse scanning unit, and features that it has also fixing unit for fixing separately the light guide unit and the transverse scanning unit in the same shaft. The transverse scanning unit consists of micro motor and connected reflector, and the reflector is driven by the motor to reflect light to the sample for scanning. The present invention utilizes micro motor to provide OCT transverse scanning so as to obtain the high resolution cross section image of human internal organ. The probe unit has the features of small size, simple operation, etc. and utilizes the high resolution and fast imaging of OCT imaging, so that it has excellent application foreground in medicine field.

The invention discloses Fe3O4 nano-particles with high dispersion stability in water phase, and a preparation method of the Fe3O4 nano-particles. The surface ligand of each Fe3O4 nano-particle is poly-carboxyl organic molecule with three or more carboxyl groups; the preparation method of the Fe3O4 nano-particles comprises the steps of: firstly, taking high boiling point organic solvent as solvent and oleic acid as the ligand; carrying out high-temperature thermal decomposition on iron oleate to obtain mono-dispersed oil-soluble Fe3O4 nano-particles; and then, adopting a method of ligand exchange, and using the poly-carboxyl organic molecules to replace the oleic acid ligands on the surfaces of the oil-soluble Fe3O4 nano-particles to obtain the water-soluble Fe3O4 nano-particles. The preparation method is convenient in operation process, low in requirement for equipment and low in price of the needed raw materials, and by-products are pollution-free. The water-soluble Fe3O4 nano-particles have better water system dispersion stability within the pH value range of 2-13, and a new economical and practical method is provided for preparing hydrophilic Fe3O4 nano-particles applied to the biological medicine field.

The invention discloses a preparation method of functional fluorescence carbon nanoparticles (CNPs) based on natural saccharide materials and representation and application thereof in measurement for biotechnique. The preparation method is characterized by comprises the following steps of dissolving 1g of carbon sources (cellulose, starch, chitosan and cyclodextrin) and 0.1g of NaOH into 15ml of deionized water, then reacting reacting for 4 hours in an autoclave at 160 DEG C, and carrying out acid-base neutralization and microwave treatment on the obtained carbon nanoparticles. According to the preparation method, the raw materials are abundant and cheap and are easily available, the preparation method is simple, and the synthesized nanoparticles have good fluorescence characteristic and the characteristics of stable fluorescence, dark flashing, tunable wavelength, wide excitation spectra, narrow emission spectrum and the like, and can be used as a fluorescence indicator in the biological medicine field.

The present invention provides a novel intelligent psychological assessment and intervention system through combination of a virtual reality (VR) technology. The system comprises a software subsystem,a hardware subsystem and a database subsystem. The software subsystem mainly comprises user data collection and analysis software, virtual reality environment construction and processing software andbackground control software; the hardware subsystem mainly comprises a computer platform, a location base station tower, virtual reality glasses, operation handles, data gloves, a tracker and earphones; and the database subsystem is mainly configured to manage immersion 3D scene, video, audio, user physiology, psychological data and analysis results, psychological intervention content and data oftheory teaching content of psychology and other related medicine fields. The novel intelligent psychological assessment and intervention system is convenient for operators to instantly and scientifically assess and relieve the psychologic problems and physical complaints, can make up the deficiency of medicine resources related to the psychology and the deficiency of low efficiency, can be widelyused to promote psychological knowledge and can promote well-developed both in mind and body in the whole people.

The invention discloses a preparation method of a hydroxyapatite nano-rod, which adopts an oleic acid-ethanol-water phase transfer system with low cost to prepare the hydroxyapatite nano-rod with uniform size, controllable appearance and nano-scale. The hydroxyapatite nano-rod is prepared by the steps as follows: a. firstly, the oleic acid, ethanol and an additive are mixed; b. secondly, a calcium salt aqueous solution is dispersed into the oleic acid-ethanol mixed medium; the volume content of the calcium salt aqueous solution in a final mixed solution is 5 percent to 15 percent; the mass volume concentration of the calcium salt is 0.1 percent to 10 percent; c. then,a phosphate aqueous solution is added and mixed at room temperature; the mass volume concentration of the phosphate is 0.1 percent to 10 percent; d. the mixture generated from step c reacts in a reactor between 80 DEG C and 200 DEG C; e. centrifugation is carried out to remove a supernatant fluid and the obtained object is washed by a cleaning solvent and then dried so as to obtain the hydroxyapatite nano-rod. The preparation method is characterized by low production cost and comparatively high product quality, thus being hopeful to be applied in the medical field.

The invention relates to novel application of berberine and derivatives thereof in preparation of medicines, in particular to application of berberine and derivatives thereof in preparation of indole amine 2, 3-dioxygenase IDO inhibitor, belonging to the medicine field. According to IDO inhibition activity detection, reversible inhibition judgment, inhibitor type judgment, Ki value determination and median effective inhibition concentration IC50 determination, the results show that berberine is reversible inhibitor and inhibition constant Ki is 8muM; and jatrorrhizine hydrochloride and palmatine hydrochloride are irreversible inhibitors, and the median effective inhibition concentrations IC50 thereof are respectively 123muM and 126muM. When the berberine and the derivatives thereof disclosed in the invention are used as IDO inhibitors, the application prospect is wide and the IDO inhibitors can be used for treating serious diseases such as cancers, AIDS, Alzheimer diseases, tristimania, cataract and the like with pathological feature of IDO-mediated tryptophan metabolism.

The invention provides an artificial hollow micro-nano motor and a preparation method thereof, relating to artificial motors and preparation methods thereof and solving the problem that the existing solid spherical motor, tubular motor and linear motor are poor in loading performance. The artificial hollow micro-nano motor is made from a polyelectrolyte double-layer skeleton and a catalyst or is made from a cationic polyelectrolyte skeleton and the catalyst; and the preparation method of the artificial hollow micro-nano motor comprises the following steps of: (1) preparing micro-nano catalyst particles; (2) synthesizing a core substrate; (3) synthesizing an artificial hollow micro-nano motor skeleton; and (4) removing the core substrate by using a template solvent so as to obtain the artificial hollow micro-nano motor. The preparation method has the advantages of simplicity and feasibility, stable process, good repeatability and convenience in mass production, and the prepared artificial hollow micro-nano motor is good in transportability and loading function, has a wide application prospect in a plurality of aspects, such as drug release control, blood purification, clinical diagnosis, and is simple in operation. The artificial hollow micro-nano motor prepared by the preparation method provided by the invention is applicable to the medical field.

The invention provides knowledge graph-based precise-recommendation technology of offline medicine retail. The technology is based on a medicine knowledge graph. The graph mainly includes entities ofdiseases, Chinese and Western medicine, people groups, health products and the like and association relationships among the entities. The association relationships mainly include contraindication relationships, interaction relationships, inclusion relationships, adjoining relationships, assistance relationships, affiliation relationships and the like. A people group set is generated through a people group label generation algorithm based on density clustering, and contains people group category labels and medicine commodities belonging to all the labels; then a target user is labeled accordingto a medicine combination bought by the user; and finally, interest degrees of the user are calculated according to a label, and a recommendation result list is generated. The technology can solve the problems which are of sparseness and single categories of user data and are encountered by medicine retail enterprises in precise recommendation, and the medicine knowledge graph on which the technology is based can also solve the problem of particularity of the medicine commodities and the problem of medicine field knowledge lacking of users. The technology can satisfy most precise-recommendation service demand in an offline medicine retail environment, and has very high market competitiveness and broad application prospects.

The present invention provides a release oxygen type stephanoporate abio/organic composite stent material which is composed of abio-hyperoxide, anhydrous hydrogen phosphate and degradable polymericcompound which contains non-ionic surface active agent, wherein, hyperoxide weight is 1%-10% of degradable polymericcompound weight, molar ratio of anhydrous hydrogen phosphate to hyperoxide is 1.0-2.0:1, non-ionic surface active agent weight is 10%-40% of degradable polymericcompound weight, the porosity of the stent material is larger than 90%. A preparing method includes steps as follows: preparing a ceresin wax micro-ball firstly, preparing a symmetric suspension body composed of non-ionic surface active agent, hyperoxide, anhydrous hydrogen phosphate and degradable polymericcompound, pouringin a die equipment filled with ceresin wax micro-ball, then freezing forming, freezing dehydration and removing organic solvent, finally, removing ceresin wax micro-ball by using organic solvent andobtaining the products. The stent material has advantages of continuous oxygen releasing, favorable biocompatibility, biodegradability, biological activity and hydrophilicity which is suitable for thebiological medicine field and the organizing engineering project field.

The invention relates to a polyurethane which uses poly(exsilon-caprolactone) as soft block and has shape memory function. It is made up by using poly(epsilon-caprolactone) (PCL) of double hydroxyl and diisocyanate and small moleculeg glycol (EO) through process of reaction. Its melting point is in the range of 40 deg.C-60 deg.C, and is dependent on the molecular weight of PCL and the mole ratio of PCL and EO, and its restorable deformation temperature is room temperature to 60 deg.C and the deformation restorable temperature is room temperature to 60 deg.C and the deformation restorable temperature is room temperature to 50 deg.C, and also is dependent on the molecular weight of PCL and mole ratio of PCL and EO. Under the condition of that the extension is 300% and compresses is three times its deformation restoration rate can be up to 100%. Its deformation restorable temperature can be controlled near by human body temperature by utilizing regulation of polymer composition, so that it has biodegradation function and can obtain important application in medicine field.

The invention discloses a mesoporous silica particle compound carrier with a controlled-release function. The core of the carrier is a spherical or rodlike mesoporous silica particle with a regular mesoporous passage; the external surface of the particle is covered by a silica nano-particle or titanium dioxide nano-particle thin layer; the thickness of the thin layer is 30-150nm and can be specifically controlled by changing the mass ratio of mesoporous particles in a suspending liquid and nano-particles in sol; the preparation method of the mesoporous silica particle compound carrier comprises the following steps of: dispersing a certain amount of silica sol or titanium dioxide sol and rodlike SBA-15 or spherical MCM-41 in water to prepare a suspending liquid, and then carrying out spray drying on the suspending liquid by using a spray dryer, wherein the drying temperature is 160-220 DEG C. The mesoporous silica particle compound carrier prepared by using the preparation method can be used as the controlled-release carrier of a functional object such as an inorganic packing material, an antibacterial agent and the like in fields of rubber plastics and coatings and the carrier of medicine controlled-release formulations in medicine fields and can be applied to the environmental friendliness field for adsorbing harmful substances.

The invention belongs to the biological medicine field, and relates to a method using penicillin fermentation liquor for direct preparation of 6-aminopenicillanicacid. Preparation methods of the 6-aminopenicillanicacid in the prior art have the technical problems of large environmental pollution, high energy consumption, low product yield and the like; in order to overcome the technical problems, the invention provides the method using the penicillin fermentation liquor for direct preparation of the 6-aminopenicillanicacid, the method avoids use of butyl acetate, n-butyl alcohol and other organic solvents, improves the product yield, reduces the energy consumption in the process of preparation, is a green energy-saving 6-aminopenicillanicacid production method, and is very suitable for popularization and application in industry.

The invention belongs to the genetic engineering and tumour medicine fields and discloses an SNP marker related to primary hepatocellular carcinoma auxiliary diagnosis and an application of the SNP marker. The marker is a combination of rs7574865, rs1012068, rs17401966, rs2596542, rs455804, rs9272105, rs9275319 and rs9275572. The marker can be used for preparing a hepatic carcinoma auxiliary diagnosis kit.

The invention relates to a preparation method of a segmented copolymer material P(MMA-co-DMAEMA)-b-PPEGMA with temperature and pH (Potential of Hydrogen) sensitivity. According to the method, a copolymer poly(methyl methacrylate-co-dimethylaminoethyl methacrylate) is synthesized by adopting a reversible addition-fragmentation chain transfer polymerization method firstly; the synthesized poly(methyl methacrylate-co-dimethylaminoethyl methacrylate) as a macromolecular chain transfer agent is subjected to RAFT (Reversible Additive Fragment Transfer) polymerization with polyethylene glycol methyl ether methacrylate, so as to obtain the segmented copolymer material P(MMA-co-DMAEMA)-b-PPEGMA with the temperature and pH sensitivity. The method provided by the invention has the characteristics of simplicity and convenience, high preparation yield, no pollution to environment and the like; the prepared polymer material has high functionality and narrow molecular weight distribution, can be applied to organic dye adsorption and heavy metal adsorption, and medicine fields including in-vivo transportation of difficultly-soluble anti-cancer medicines and the like.

The invention relates to a composition for preparing a modified starch matrix-containing hard capsule, which relates to the food and medicine fields. The composition for preparing the modified starch matrix-containing hard capsule comprises 55-95wt% of modified starch and 5-45wt% of gellant as matrix; and the modified starch is the modified starch containing 1-2.5wt% of acetyl and 0-6.5wt% of hydroxyl propoxy. The modified starch matrix-containing hard capsule is capable of performing molecular chain modification on the starch matrix, a steric group is introduced on the starch molecule and then hydrophobic modification is carried out, intermolecular hydrogen bond force of starch is overcome, so that the modified starch matrix-containing hard capsule has toughening enhancement effect; a tridimensional net structure is constructed by adding a composite plant gelatinizing agent, so that toughening and plasticising effects are generated, and thereby hard capsule with good flexibility can be prepared.

The invention provides an intelligent medicine cabinet system and relates to the field of intelligent medicine cabinets. The intelligent medicine cabinet system is achieved based on an intelligent medicine cabinet touch screen and an intelligent medicine cabinet lock and comprises a bar code reader, an upper computer module and a lower computer module; the intelligent medicine cabinet touch screen is used for displaying and inputting information; the bar code reader is used for reading identity data information and sending the data information to the upper computer module; the upper computer module is used for performing identity authentication and sending control instruction data, wherein the identity authentication is achieved through a medicine storage location matching library and an identity matching library which are arranged in the upper computer module; the lower computer module is used for receiving the control instruction sent out of the upper computer module and driving the intelligent medicine cabinet lock and accordingly opening, closing and early-warning of the intelligent medicine cabinet lock can be performed. The intelligent medicine cabinet system is applied to the medicine field specifically. According to the intelligent medicine cabinet system, the problems that the service efficiency is low, the security is poor, the medicine storage is lax, and the medicine information cannot be tracked timely in the existing process of traditional population register medicine storage and fetch management are solved.

The invention belongs to the medicine field, and particularly relates to repairing gel containing growth factors and a preparation method of the repairing gel .The repairing gel is prepared from 0.001%-0.02% of the growth factors, 0.05%-1% of alkaline polysaccharides, 0.5%-2% of a cellulose derivative water-soluble polymer, 0.05%-2% of natural plant polysaccharides, 0.01%-1% of a natural water-soluble polymer of extracellular polysaccharides, 0.1%-2% of carbomer, 12%-40% of a wetting agent, 0.05%-4% of a pH regulating agent, 0.01%-2% of hyaluronic acid, 0.6%-3% of a transdermal absorption agent, 0.1%-0.3% of a penetration enhancer and the balance deionized water .The repairing gel has the excellent antibacterial effect and the good moisture absorption performance and can significantly increase the cure rate of a wound surface, shorten the healing time of the wound surface and prevent scar formation.

The invention provides a new application of traditional Chinese medicine combination, namely a new application in healthcare food and medicine field. Actually, the invention relates to the applications of a medicine combination consisting of the following components in parts by weight ratio: 10-50 parts of ginseng, 10-50 parts of ganoderma lucidum, and 10-50 parts of fermentative cordyceps sinensis powder, in preparing healthcare foods and medicines capable of treating/preventing and releasing physical fatigue, or reducing blood fat, or preventing oxidation; in addition, the invention relates to the applications of a medicine combination consisting of the following components in parts by weight ratio: 10-50 parts of ginseng, 10-50 parts of ganoderma lucidum, 10-50 parts of fermentative cordyceps sinensis powder and 10-40 parts of rose, in preparing healthcare foods and medicines capable of treating/preventing and releasing physical fatigue, or reducing blood fat, or preventing oxidation.

The invention discloses a Chinese medicine for remedying lymphoma, nasopharyngeal carcinoma and brain tumor, and relates to the Chinese medicine field. The prior cancer remedying method of western medicine mainly adopts surgical operation, radiotherapy and chemotherapy methods, the curative effect of which is not ideal. The cancer remedying method of western medicine damages the healthy organisms to a certain extent. Chinese medicine cures the cancers dialectically, invigorates yang and restrains yin, and achieves the purpose of exterminating cancer cells. The Chinese medicine is made from a plurality of raw materials of field pennycress, sargentgloryvine stem, motherwort, flagleaf and so on. The raw materials are crushed and sieved by a 360 sieve. The ferruginous contents are removed by magnetization. After being sterilized, the crushed raw materials are filled in small bags. The Chinese medicine can be taken by decocting into decoction which can be taken separately or taken together with residues. The clinical trial proves that the invention has the beneficial effect that the Chinese medicine is quick to take effect, has high curative effect and simple preparation technology, is convenient to be popularized, has low cost, not only is favorable to the treatment of patients, but also is suitable for the illness prevention for healthy people.

The invention relates to the fields of rehabilitation engineering, neural engineering and dyskinesia mechanism research, in particular to an electroencephalogram and electromyogram synchronous acquisition and information transfer characteristic analysis method. The method includes an electroencephalogram and electromyogram synchronous acquisition step and a signal processing step, the electroencephalogram and electromyogram synchronous acquisition step includes electroencephalogram acquisition and electromyogram acquisition, and the signal processing step includes signal preprocessing and an electroencephalogram and electromyogram transfer characteristic analysis method. The method has applicability and adoptability and has significant application value in the rehabilitation medicine field.

The invention relates to the medicine field and specifically discloses an arthralgia relieving gel. The arthralgia relieving gel is prepared from raw materials including the following components in parts by weight: 160-240 parts of capsicum fluid extract, 90-140 parts of atropa belladonna fluid extract, 30-50 parts of dementholized peppermint oil, 70-90 parts of methyl salicylate, 160-240 parts of camphor, 10-15 parts of diphenhydramine hydrochloride, 1-10 parts of triethanolamine, 2-30 parts of carbomer, 1-3 parts of ethylparaben, 3-40 parts of hydroxypropyl methylcellulose, 50-100 parts of glycerin, 1-10 parts of ethanol, 1-5 parts of azone and a proper quantity of water; all the raw material components are of 1000 parts in total. The invention also discloses a preparation method of the arthralgia relieving gel. Compared with the existing arthralgia relieving plaster in the prior art, the arthralgia relieving gel has the advantages of good stability, easy absorption, remarkable medical effect, low skin irritation and safe production.