The invention discloses an esophageal cancer clinical decision-making, teaching and scientific research auxiliary support system and method. According to the system and method, a medical and pharmaceutical data storage unit, a diagnosis and treatment parameter storage unit, an information input unit, a comparison processor unit, a diagnosis and treatment result output unit, and an early warning and operation recording unit are adopted, feasible clinical diagnosis and treatment scheme suggestions and corresponding clinical research and real world research evidence support can be provided for related medical workers according to patient disease specificity information parameter values, the whole disease cycle of screening diagnosis, treatment, monitoring follow-up visit, out-of-hospital management and the like is covered, and doctors are assisted to quickly improve the clinical diagnosis and treatment level, learn and update diagnosis and treatment knowledge, master the research status and development direction of clinical research and real-world diagnosis and treatment, and improve the scientific research level, thereby solving the contradiction that time and energy of medical workers are difficult to follow the clinical research progress.