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Application of bergapten in treatment of depression

A technology of bergamot lactone and depression, which is applied in the field of medicine, can solve the problems of bergamot lactone action and efficacy that have not been reported yet, and achieve good anti-inflammatory effect, reduce the amount, and good preventive effect

Pending Publication Date: 2021-12-17
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the present invention relates to the effect and efficacy of bergamot lactone in antidepressant and there is no relevant report

Method used

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  • Application of bergapten in treatment of depression
  • Application of bergapten in treatment of depression
  • Application of bergapten in treatment of depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 animal feeding and grouping

[0031] (1) Experimental animals

[0032] Forty 6-week-old male C57BL / 6J mice were purchased from Beijing Weitong Lihua Experimental Animal Co., Ltd., with an average body weight of 21-25 g. The mice were kept in a clean or SPF animal room with a room temperature of 23°C and a 12-hour day-night cycle. Before the start of the experiment, they were adaptively fed for one week and had free access to water during the feeding period. Mice were housed in groups until behavioral testing began.

[0033] All animal experiments were reviewed and approved by the Biological and Medical Ethics Committee of Minzu University of China.

[0034] (2) Drug preparation and administration

[0035] 1) Dissolve bergamot lactone (BG) in dimethyl sulfoxide (DMSO), and inject intraperitoneally at 10 mg / kg mice

[0036] 2) LPS was dissolved in physiological saline and administered by intraperitoneal injection at 1 mg / kg to mice.

[0037] (3) Establis...

Embodiment 2

[0041] Example 2 Effect of bergamot lactone on depressive-like behavior in mice

[0042] 1. Behavioral test

[0043] (1) Open field test

[0044] The open field test is a method to evaluate the autonomous behavior, exploratory behavior and tension of mice in a novel environment. The mice were put into the experimental environment 2 hours before the experiment for pre-adaptation. During the experiment, the mice were placed in a test box with a size of 32 × 32 cm. Start the test program, record the spontaneous activities of the mice within 5 minutes, and count the total distance of the mice's activities and the time spent in the central area. After each mouse was tested, it was cleaned with 75% ethanol solution and put into the next one after drying. Experimental results such asfigure 1 As shown in A-C, there was no significant difference in the total moving distance and the time spent in the central area of ​​the four groups of mice, and bergamot lactone had no significant ...

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Abstract

The invention discloses application of bergapten in treatment of depression, and belongs to the technical field of medicines. The invention provides a natural medicine bergapten for preventing and treating depression by regulating inflammatory response for the first time, and the depression symptom is remarkably improved. The bergapten enables the immobility time of lipopolysaccharide (LPS)-induced anti-depression mice in a tail suspension test and a forced swimming test to be obviously reduced; the sweet water preference percentage is increased, and the autonomous activity is enhanced; and the action mechanism is related to the neuroinflammatory response mediated by the activation of depression mouse microglial cells. The invention provides a new way for improving the current depression treatment method. According to the scheme, new use of old medicines can be realized, and the time from medicine discovery to clinical transformation can be greatly shortened.

Description

technical field [0001] The invention relates to the application of bergamot lactone in treating depression and belongs to the technical field of medicine. Background technique [0002] Depression is a major mental illness that plagues human health around the world. About 350 million people around the world have been diagnosed with depression, and the incidence of depression is increasing year by year. The pathogenesis of depression is relatively complex, and a clear and unified theoretical mechanism has not yet been formed. Studies have shown that the inflammatory response produced by stress is an important way to induce depression. Most of the antidepressant drugs currently used clinically have unacceptable side effects and slow effect, so safe and effective new antidepressant drugs urgently need to be further developed. [0003] In recent years, traditional Chinese medicine has achieved remarkable clinical efficacy in the treatment of depression, and more and more reports...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61K45/06A61P25/24A23L33/105
CPCA61K31/37A61K45/06A61P25/24A23L33/105A23V2002/00A61K2300/00A23V2200/322A23V2250/21
Inventor 程金波闫美辰薄雪娜
Owner MINZU UNIVERSITY OF CHINA
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