Externally-used gel preparation for treating erythromelalgia and preparation method of externally-used gel preparation

Abstract

The invention discloses an externally-used gel preparation for treating erythromelalgia and a preparation method of the externally-used preparation. The externally-used gel preparation is mainly prepared from components in parts by weight as follows: 2-4 parts of promethazine hydrochloride, 1.1-1.5 parts of paeonol, 0.3-1.2 parts of diphenhydramine hydrochloride, 0.1-0.42 parts of an alpha adrenergic receptor stimulant, 0.5-1.3 parts of ursolic acid, 0.6-0.7 parts of diclofenac sodium, 1.2-2.0 parts of bergapten, 1.5-3.4 parts of magnesium sulfate, 0.1-0.7 parts of chavicol, 0.12-0.25 parts of naringin, 0.8-2.0 parts of eucalyptol, 20-34 parts of a gel matrix, 0.03-0.06 parts of an antioxidant, 0.02-0.04 parts of a preservative and 0.05-0.1 parts of a solubilizer. The externally-used gel preparation for treating erythromelalgia has the functions of shrinking blood vessels and reducing the vascular permeability, can also relieve pain and resist inflammation and bacteria and can remarkably relieve redness, swelling, heat and pain of lower limbs in a short period of time; the externally-used gel preparation which is locally applied is prepared from the medicines, the absorption and utilization rate of the preparation is high, the safety is also higher, and clinical experiments show that the externally-used gel preparation has a good curative effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an external gel preparation for treating erythromelalgia and a preparation method thereof. Background technique [0002] Erythromelalgia (Erythromelalgia) is a peripheral vasomotor dysfunction of unknown cause, clinically characterized by skin redness, swelling, pain, and heat on the extremities, mostly occurring on the feet. In 1878, Mitchell first reported a disease characterized by red, swollen, hot, and painful skin on the fingertips, and named it erythromelalgia. In 1964, Babb et al. divided the disease into two types: primary and secondary. In 1995, Professor Wang Jiaju defined a type of erythromelalgia with epidemic characteristics that mainly occurred in southern my country as idiopathic erythematalgia. [0003] The etiology and pathogenesis of erythromelalgia have not been clarified, and it may be related to the dysfunction of extremity capillary dilation caused by co...

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs for the treatment of this disease mainly include: painkillers such as aspirin, drugs that constrict and dilate blood vessels such as anti-serotonin antagonists Descelil, ephedrine, diazepam, isoproterenol, nitroglycerin, sodium nitroprusside, Reserpine, chlorpromazine, rifampin, and corticosteroids and other drugs, and traditional Chinese medicine treatments such as traditional Chinese medicine fumigation, acupuncture, nursing cold compress, etc., can all achieve certain curative effects, but the effect is not significant enough