Oil-in-water cinnamic aldehyde nano emulsion medicament

A technology of oil-in-water type and cinnamaldehyde, which is applied in the field of medicine, can solve the problems of poor stability, easy volatilization, and low bioavailability, and achieve the effects of improving storage stability, increasing solubility, and simple method and process

Inactive Publication Date: 2012-01-04
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both oil and alcohol solvents have the disadvantages of easy volatility, poor stability and low bioavailability

Method used

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  • Oil-in-water cinnamic aldehyde nano emulsion medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 1) Weigh 31.70g of Tween-80, 2.53g of absolute ethanol, 2.00g of 1,2-propanediol, 1.20g of vitamin E oil, 3.33g of cinnamaldehyde, and 59.24g of distilled water, and set aside;

[0053] 2) Mix Tween-80 with absolute ethanol and 1,2-propanediol, and stir well;

[0054] 3) Mix cinnamaldehyde and vitamin E oil, stir well;

[0055] 4) Mix the solution prepared in step 2) with the solution prepared in step 3), stir evenly, then slowly add distilled water dropwise to the mixture, stirring while adding, the mixture system will change from thin to viscous during the process of adding distilled water and stirring Thickness, and a series of changes from viscous to thin, until the formation of oil-in-water nanoemulsion.

Embodiment 2

[0057] RH40 37.19g, wheat germ oil 1.03g, cinnamaldehyde 3.10g, distilled water 58.68g.

Embodiment 3

[0059] RH40 33.22g, cinnamaldehyde 8.31g, distilled water 58.47g.

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Abstract

The invention discloses an oil-in-water cinnamic aldehyde nano emulsion medicament. The particle diameter of the nano emulsion is between 10 and 100 nanometers; and the medicament is prepared from the following raw materials: 18.09 to 37.19 percent of surfactant, 0 to 6.86 percent of cosurfactant, 0 to 8.62 percent of oil, 0.10 to 8.31 percent of cinnamic aldehyde and the balance of distilled water, wherein the mass percentage sum of the components is 100 percent. According to the oil-in-water cinnamic aldehyde nano emulsion medicament, the dissolubility of the cinnamic aldehyde is enhanced, the stability of the medicament is improved, the bioavailability is improved, the medicament metabolizing time of the cinnamic aldehyde in vivo is delayed, the consumption of the auxiliary material is reduced, and the production cost is lowered; and the medicament has broad market prospect in the field of medicine.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of cinnamaldehyde that can kill fungi, inhibit bacteria, resist ulcers, enhance gastrointestinal function, and lower blood sugar and blood lipids, in particular to a clear and transparent oil-in-water type cinnamaldehyde nanoemulsion drug. Background technique [0002] Cinnamaldehyde, also known as cinnamaldehyde, occurs naturally in essential oils such as cinnamon, cassia, patchouli, hyacinth, and rose oils. Cinnamaldehyde can now be chemically synthesized. Cinnamaldehyde has the function of sterilization, disinfection and anticorrosion, especially for fungi. Cinnamaldehyde has a mild stimulating effect on the stomach, can promote the secretion of saliva and gastric juice, enhance digestive function, and relieve gastrointestinal smooth muscle spasm and pain. It is used to treat stomach pain, flatulence and colic, and has obvious effects of invigorating the stomach and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/11A61P31/10A61P31/04A61P1/04A61P1/14A61P3/06A61P3/10
Inventor 欧阳五庆吴敬超欧阳伸雨
Owner NORTHWEST A & F UNIV
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