51 results about "Promethazine Hydrochloride" patented technology

The invention discloses a drug combination and a preparation method thereof. The compositions of the drug combination comprise reserpine, hydrochlorothiazide, promethazine hydrochloride, dihydralazine sulfate, vitamin B6, calcium pantothenate, vitamin B1, magnesium trisilicate, potassium chloride and one or more acidic substances. The drug combination and the preparation method thereof provided by the invention have the advantages that the manufactured drug combination can be used for treating early-stage and middle-stage hypertension diseases.

A pharmaceutical composition for treating hypertension and a preparation method of the pharmaceutical composition are disclosed. The invention provides compound reserpine tablets, which comprise reserpine, hydrochlorothiazide, vitamin B6, vitamin B1, calcium pantothenate, magnesium trisilicate, potassium chloride, dihydralazine sulfate, promethazine hydrochloride and a pharmaceutically-acceptable carrier, wherein vitamin B1 is available in the form of coated granules.

The invention discloses a formula of a cough-relieving medicament and a preparation method thereof. The medicament is composition solution prepared by procedures such as decoction, filtering, boiling and mixing of folium eriobotryae, pericarpium papaveris, radix stemonae, cynanchum glaucescens, the root bark of white mulberry, platycodon grandiflorum, menthol crystal, cane sugar, citric acid, essence, sodium benzoate, dextromethorphan hydrobromide, promethazine hydrochloride, 75% of alcoholic solution, distilled water and the like. The cough-relieving medicament can be suitable for curing cough caused by various respiratory incentives. After patients orally take the cough-relieving medicament, no body function allergic reaction occurs. The cough-relieving medicament has no toxic or side effect and can be rapidly absorbed and utilized by bodies. The cure purpose of relieving cough and asthma can be achieved by tonifying kidneys, strengthening spleens and moistening lungs. The cough-relieving medicament is low in cost, and the preparation process is simple, convenient and easy to implement.

The invention discloses a method for determining the dissolution rate of five components in compound reserpine tablets through ultra-performance liquid chromatography, and relates to the field of analytic chemistry. The method comprises the steps that gradient elution is performed on a mobile phase composed of a mobile phase A and a mobile phase B; the mobile phase A is a water solution containinghexanesulfonate, wherein the concentration of the hexanesulfonate is 0.05-0.1%, and pH is 2.5-3.0; the mobile phase B is a mixing solution of methyl alcohol and acetonitrile, and the volume ratio ofmethyl alcohol to acetonitrile is (4.5-5.5):1; peaks can be effectively separated out from the five components of vitamin B1, vitamin B6, hydrochlorothiazide, dihydralazine sulfate and promethazine hydrochloride in the compound reserpine tablets, the number of theoretical plates and the separation degree meet the requirements, the separation effect is obvious, and the dissolution rate of five components in compound reserpine tablets can be determined; the method has the advantages of being simple, rapid, high in sensitivity, good in selectivity and the like.

The invention relates to a high stability composite guaiacol phenolsulfonic acid oral liquid and a preparation method thereof, and belongs to the technical field of pharmaceutics. The oral liquid is prepared by adopting promethazine hydrochloride, guaiacol phenolsulfonic acid, ammonium chloride, sodium citrate, benzoic acid, ethylparaben, cane sugar, caramel, Litchi chinensis essence and banana essence as raw and auxiliary materials, adding an antioxidant cysteine hydrochloride or vitamin C and adopting ethanol and water as a solvent. According to the invention, deficiencies of conventional formula are improved, and the antioxidant is added to effectively prevent promethazine hydrochloride form being oxidized. The guaiacol phenolsulfonic acid oral liquid prepared by the formula and process is high in stability in the placing process, so that the medicine quality and medication safety of patients can be effectively ensured.

The invention provides a composition for treating anaphylactic rhinitis and a drug pillow. The composition comprises astragali radix, bran-fried largehead atractylodes rhizome, divaricate saposhnikovia roots, wild flat-cover ganoderma applanatum, wild sessile ganoderma lucidum, wild laetiporus sulphureus, wild ganoderma capense, liquor rhizoma polygonati, radix polygonati officinalis, mulberry fruits, pokeberry roots, eclipta alba, dangshen, poria cocos, fried cocklebur fruits, biond magnolia flowers, centipeda minima, as arum, angelica roots, cicada sloughs, burdock, mint, borneol, camphor, promethazine hydrochloride and chlorpheniramine maleate. The composition and the drug pillow are simple, convenient and feasible, safe and reliable, and stable in curative effect when used for treating the anaphylactic rhinitis.

The invention belongs to the field of pharmacy, and particularly relates to a compound reserpine orally disintegrating tablet for treating hypertension and a preparation method of the compound reserpine orally disintegrating tablet. The compound reserpine orally disintegrating tablet is prepared from the following raw and auxiliary materials in parts by weight: 0.03 part of reserpine, 1 part of hydralazine hydrochloride, 0.025 part of cyclopenthiazide, 1.5 parts of hydrochlorothiazide, 2 parts of promethazine hydrochloride, 30 parts of potassium chloride, 5 parts of rutin, 2.5 parts of phosphate chloroquine, 1 part of vitamin B1, 1 part of vitamin B6, 2-10 parts of a stabilizer fumaric acid and other pharmaceutical adjuvants. An experiment result shows that the orally disintegrating tablet is short in onset time, long in medicine duration time, and convenient for treatment of a patient for a long period of time; the medication safety is improved; meanwhile, the prescription is high in process stability, and is free of effects of environmental temperature and humidity; and the difference between batches of the preparations is significantly reduced; and the stability of a sample is improved.

The invention discloses a compound drug, particularly relating to a compound antihypertensive drug and a preparation method thereof and belonging to the field of medicine technology. The compound antihypertensive drug is prepared by the following bulk drugs according to parts by weight: 2 parts of hydrochlorothiazide, 1.5 parts of dihydralazine sulfate, 2 parts of promethazine hydrochloride, 5 parts of rutin, 2.5 parts of chloroquine phosphate, 30 parts of potassium chloride, 1 part of thiamine hydrochloride, 1 part of pyridoxin hydrochloride, 0.03 part of reserpine, 30 parts of magnesium trisilicate, 2 to 5 parts of starch, 0.1 to 0.8 part of magnesium stearate and 10 to 30 parts of starch slurry. The compound antihypertensive drug generates low fluctuation of blood pressure in the process of reducing blood pressure for hypertension and the compound antihypertensive drug is also characterized by excellent treatment effect, low side effect, high treatment efficiency and long-lasting drug effect.

The invention belongs to the field of pharmacy, and particularly relates to a compound reserpine medicine composition for treating hypertension and a preparation method of the compound reserpine medicine composition. The compound reserpine medicine composition comprises raw materials in parts by weight as follows: 0.03 parts of reserpine, 1 part of hydralazine hydrochloride, 0.025 parts of cyclopenthiazide, 1.5 parts of hydrochlorothiazide, 2 parts of promethazine hydrochloride, 30 parts of potassium chloride, 5 parts of rutin, 2.5 parts of chloroquine phosphate, 1 part of vitamin B1, 1 part of vitamin B6, 2-10 parts of a stabilizer fumaric acid and other pharmaceutical adjuvants. Experiment results show that the medicine composition takes effect quickly, has long-lasting medicine efficacy, facilitates long-term treatment of a patient and is safe to take; besides, the formula has a high technological stability and is not influenced by environmental temperature and humidity, differences between different bathes of preparations are remarkably reduced, and the stability of samples is improved.

The invention belongs to the field of medicine preparation, and in particular relates to a promethazine hydrochloride tablet and a preparation method thereof. The preparation method comprises the following steps: firstly, weighing poloxamer and PEG6000 to prepare an auxiliary solution, further preparing a main medicine solution from an effective component promethazine hydrochloride, and uniformly mixing the auxiliary solution and the main medicine solution, thereby obtaining a mixed solution; performing vacuum drying on the mixed solution; crushing the obtained solid material, adding other excipient, putting into a granulator for shearing and granulation, and putting into a boiling dryer for drying; screening and shaping the dried granules, mixing the obtained granules and a lubricant of the formula, and subsequently tabletting.

The invention belongs to the field of medicines, and provides a long-acting pain relieving mixture used after anorectal surgery. The long-acting pain relieving mixture is prepared from methylene blue injection, promethazine hydrochloride injection, lidocaine hydrochloride injection and sodium chloride injection in certain proportion, has a long-acting pain relieving effect after surgery and can also be used for solving local burning pain caused within 3-4 hours. Compared with a conventional local injection long-acting pain relieving mixture, the long-acting pain relieving mixture has the obvious advantages of definite curative effect, long-acting pain relieving and no side effects. The long-acting pain relieving mixture is suitable for infiltrating injection below wound surface mucosae after anorectal surgery such as hemorrhoids, anal fissure, anal fistula and rectocele.

The invention relates to a medicinal composition for treating phlegm and relieving cough, and in particular relates to a high-stability compound potassium guaiacolsulfonate oral solution and a preparation method thereof. The composition comprises the following components: potassium guaiacolsulfonate, promethazine hydrochloride, ammonium chloride, citric acid, sodium citrate, xylitol, benzoic acid, an antioxidant, a pH regulator and propylene glycol and purified water as solvents. The compound potassium guaiacolsulfonate oral solution prepared by the method has the advantages of high stability during storage process, low tendency to crystallization, long validity period and the like, and effectively ensures the quality of a medicine and the safety of patient's medication.

The invention relates to an oral medicine for treating asthma, and a preparation method thereof, and aims to solve problems that traditional Chinese medicine takes effect slowly while the curative effect of western medicine can not meet patients' satisfaction. The oral medicine is prepared by raw drug materials according to the following weight ratio: 150-300 of pheretima, 2.5-5 of promethazine hydrochloride, 20-50 of radix asteris, 50-100 of white ammonium chloride, 20-50 of radix stemonae, 56-112 of extractum glycyrrhizae, 1-2 of camphor and 1-2 of star anise oil. The preparation method comprises the following steps of (1) smashing a specified amount of pheretima, promethazine hydrochloride, radix asteris, white ammonium chloride, radix stemonae, and camphor into fine powder respectively; and (2) mixing the smashed raw drug materials with a specified amount of extractum glycyrrhizae and star anise oil thoroughly, and making into tablets, pulvis and capsules or other oral preparations. The oral medicine has the functions of relieving asthma, tranquilization, moistening lung to relive cough and resisting allergy, can be used for treating bronchitis, emphysema and asthma, takes effect quickly, and has high cure rate.

The invention discloses a decoction for eliminating phlegm and relieving asthma and a preparation technology. The decoction is characterized by being a composition solution prepared from the following steps: mixing and decocting bulbus fritillariae cirrhosae, common nightblooming cereus, steamed egg white, perillaseed, apricot kernel, pork lung, root bark of white mulberry, folium eriobotryae, semen brassicae, fresh ginger, brown sugar, oleum menthae, citric acid, potassium sorbate, dextromethorphan hydrobromide, promethazine hydrochloride and the substances such as white vinegar and distilled water. The decoction can be applicable to various kinds of sputum, cough and asthma caused by respiratory tracts, and is free of anaphylactic reaction in body function after being orally taken, and free of a toxic or side effect; the medicines can be rapidly absorbed and utilized by the body, so that the aims of eliminating phlegm and relieving asthma are achieved by reinforcing the kidneys, strengthening the spleen and moistening the lung; the cost is low; and the preparation technology is simple and feasible.

The invention relates to the technical field of preparation and application of capillary electrochromatography monolithic columns, and discloses preparation and application of a bis[-6-N-(imidazolyl-2-amino-propionic acid-3-)]-beta-CD (beta-CD-E2) capillary electrochromatography (CEC) monolithic column; the CEC column is prepared from beta-CD-E2, and enantiomers of chiral substances can be split.The preparation comprises the steps: 1, constructing a chiral environment by beta-CD-E2, preparing a unique chiral CEC column from beta-CD-E2, a secondary functional monomer and the like, and applyingthe unique chiral CEC column to efficient capillary electrophoresis; 2, searching the optimal formula and conditions through proper characterization means, and optimizing the method and conditions; and 3, preparing a chiral CEC column detachable chiral compound from the prepared beta-CD-E2 with an acid-base amphoteric group, and establishing four receptor antagonists, namely terazosin hydrochloride (TER), promethazine hydrochloride (PMZ), doxazosin mesylate (DOX) and hydroxypropyl piperazine (DROP), two herbicides, namely imazethapyr (IMZR) and imazethapyr (IMZC) and other chiral compounds. The invention discloses an enantiomer resolution and qualitative and quantitative analysis method.

The invention relates to a compound dibazole and hydrochlorothiazidum capsule and process for preparation, wherein the raw materials include dibazole, promethazine, chloroquine phosphate, guanoxan sulfate, vitamin B6, potassium chloride, crystoserpine, hydrochlorothiazidum, calcium lactate, vitamin B1, magnesium trisilicate and medicinal starch. The end product can effectively lower blood pressure.

The invention relates to a compound reserpine tablet for treating hypertension and belongs to the technical field of Western medicine preparation. The compound reserpine tablet is composed of the following components: 3.2 parts of reserpine, 310 parts of hydrochlorothiazide, 100 parts of vitamin B6, 100 parts of mixed spiral calcium pantothenate, 300 parts of magnesium trisilicate, 300 parts of potassium chloride, 100 parts of vitamin B1, 420 parts of dihydralazine sulfate and 210 parts of promethazine hydrochloride. A specific grain mixer is adopted for mixing. The tablet provided by the invention is slowly and stably released.

The invention belongs to the technical fields of medicines and medicine production, and in particular relates to a promethazine hydrochloride tablet and a preparation method thereof. On the basis of selecting related adjuvants and carriers, the tablet, by combining stevioside and promethazine hydrochloride, is quite ideal in formability and disintegrating performance; and meanwhile, a formula is also further simplified.

The invention discloses a phlegm-reduction asthma-relieving tablet and a preparation method thereof. The phlegm-reduction asthma-relieving tablet comprises, by mass, 220-280 parts of ladybell root, 220-280 parts of lumbricus, 700-780 parts of amur lilac seed, 120-180 parts of radix stemonae, 110-130 parts of pumice, 220-280 parts of radix scutellariae and 1-2 parts of promethazine hydrochloride. The phlegm-reduction asthma-relieving tablet obtained by the preparation method has the advantages of obvious effects, stable performances, simple preparation processes, less flow processes and low cost.

The invention discloses medicine for treating bronchitis based on the traditional Chinese and western medicine therapy. The medicine comprises the following components in parts by weight: 25-30 parts of ephedra, 10-15 parts of raw astragalus membranaceus, 20-25 parts of rhizoma discoreae, 20-25 parts of folium eriobotryae, 5-10 parts of milkwort, 8-10 parts of almond powder, 25-30 parts of dried orange peel, 20-30 parts of radix codonopsitis, 3-5 parts of raw rhizoma atractylodis macrocephalae, 5-10 parts of Szechuan-fritillary bulb, 8-12 parts of liquorice, 5-8 parts of common coltsfoot flower, 5-10 parts of white poria cocos, 8-10 parts of natural fresh bamboo juice, 3-5 parts of epimedium, 0.8-1.2 parts of promethazine hydrochloride, 0.2-0.5 part of a mixed solution of a nucleotide and casein injection as well as a BCG polysaccharide and nucleic acid injection, 1-1.5 parts of dextromethorphan hydrobromide and 2.5-3.5 parts of compound sulfamethoxazole. The medicine can effectively treat bronchitis and other respiration medicine diseases, and is convenient to take, short in treating course, effective, and free of toxic and side effects and medicine dependence. A preparation method of the medicine is simple and low in cost.

The invention relates to a traditional Chinese medicine, in particular to phlegm-reducing asthma-relieving tablets and a preparation method thereof. The tablets have good curative effects for treating symptoms such as acute and chronic trachitis, pulmonary emphysema and the like. 1000 phlegm-reducing asthma-relieving tablets are prepared from the following raw medicinal materials in grams by weight: 740g of manchurian lilac bark, 250g of adenophora tetraphylla, 250g of earthworm, 250g of scutellaria baicalensis, 150g of the tuber of stemona, 125g of honeysuckle, 124g of pumex, 200g of liquorice, 170g of semen armeniacae amarae, 130g of common hogfennel root, 100g of isatis root, 100g of perilla leaf, 100g of rehmannia, 100g of dried tangerine or orange peel, 75g of schisandra chinensis, 50g of ephedra, 50g of bulbus fritillariae cirrhosae, 50g of folium eriobotryae, 50g of flos farfarae, 50g of gypsum, 50g of fructus aurantii, 30g of bighead atractylodes rhizome, 20g of acanthopanax, 20g of radix ophiopogonis and 1.254g of promethazine hydrochloride. According to clinical statistical analysis, the curative effect of the product disclosed by the invention is obviously improved.

The invention relates to an oral medicine for treating asthma, and a preparation method thereof, and aims to solve problems that traditional Chinese medicine takes effect slowly while the curative effect of western medicine can not meet patients' satisfaction. The oral medicine is prepared by raw drug materials according to the following weight ratio: 150-300 of pheretima, 2.5-5 of promethazine hydrochloride, 20-50 of radix asteris, 50-100 of white ammonium chloride, 20-50 of radix stemonae, 56-112 of extractum glycyrrhizae, 1-2 of camphor and 1-2 of star anise oil. The preparation method comprises the following steps of (1) smashing a specified amount of pheretima, promethazine hydrochloride, radix asteris, white ammonium chloride, radix stemonae, and camphor into fine powder respectively; and (2) mixing the smashed raw drug materials with a specified amount of extractum glycyrrhizae and star anise oil thoroughly, and making into tablets, pulvis and capsules or other oral preparations. The oral medicine has the functions of relieving asthma, tranquilization, moistening lung to relive cough and resisting allergy, can be used for treating bronchitis, emphysema and asthma, takes effect quickly, and has high cure rate.

The invention discloses cough relieving medicine, which is prepared from the following raw materials in parts by weight: 1 to 3 parts of vitamin, 0.5 to 3 parts of saccharose, 4 to 10 parts of loquat juice, 2 to 6 parts of dementholised peppermint oil, 0.5 to 3 parts of propanediol, 5 to 9 parts of glycerol, 2 to 3 parts of sodium benzoate, 3 to 10 parts of ethanol solution, 150 to 300 parts of distilled water, 0.2 to 2 parts of promethazine hydrochloride and 0.5 to 1.5 parts of tartaric acid. The invention also discloses a preparation method of the cough relieving medicine. The cough relieving medicine and the preparation method provided by the invention have the advantages that the raw material resources are wide; the preparation process is simple; the production equipment investment cost is low; the medicine is applicable to large-scale industrial production. All ingredients achieve cooperated effects; the treatment time is short; the time and the money of patients can be saved; the treatment effect is much superior to that of the existing product; no toxic and side effects exist; the use effect is good; the market prospects are wide.

The invention discloses a medicine for treating rhinitis. The medicine consists of honeycombs and radix angelicae, wherein at least one traditional Chinese medicine can be added: flos magnolia, angelica sinensis, radix bupleuri, fried gardenia, radix scrophulariae, fritillaria and at least one of the following western medicines: cetirizine hydrochloride, promethazine hydrochloride and azelastine hydrochloride. The invention further discloses a production process of the medicine for treating rhinitis. The process comprises the following steps: (1) crushing raw materials; (2) adding other traditional Chinese medicines or / western medicines; and (3) preparing pills or capsules by mixed dust. The invention further discloses a production process of the medicine for treating rhinitis. The process comprises the following steps: (1) decocting the honeycombs and radix angelicae with water; (2) adding other traditional Chinese medicines or / western medicines; (3) filtering; and (4) adding propolis and beta-cyclodextrin to prepare a water decoction, an oral solution or an electuary. The medicine disclosed by the invention is good in curative effect, easily available in material, low in cost and high in utilization ratio of nutritional value.

A pharmaceutical composition for treating hypertension and a preparation method thereof. A compound reserpine tablet is provided, the tablet includes reserpine, hydrochlorothiazide, vitamin B6, vitamin B1, calcium pantothenate, magnesium trisilicate, potassium chloride, dihydralazine sulfate, promethazine hydrochloride And a pharmaceutically acceptable carrier, wherein the vitamin B1 exists in the form of coated granules.

The invention belongs to the technical fields of medicines and medicine production, and in particular relates to a promethazine hydrochloride tablet and a preparation method thereof. On the basis of selecting related adjuvants and carriers, the tablet, by combining stevioside and promethazine hydrochloride, is quite ideal in formability and disintegrating performance; and meanwhile, a formula is also further simplified.

The invention discloses an externally-used gel preparation for treating erythromelalgia and a preparation method of the externally-used preparation. The externally-used gel preparation is mainly prepared from components in parts by weight as follows: 2-4 parts of promethazine hydrochloride, 1.1-1.5 parts of paeonol, 0.3-1.2 parts of diphenhydramine hydrochloride, 0.1-0.42 parts of an alpha adrenergic receptor stimulant, 0.5-1.3 parts of ursolic acid, 0.6-0.7 parts of diclofenac sodium, 1.2-2.0 parts of bergapten, 1.5-3.4 parts of magnesium sulfate, 0.1-0.7 parts of chavicol, 0.12-0.25 parts of naringin, 0.8-2.0 parts of eucalyptol, 20-34 parts of a gel matrix, 0.03-0.06 parts of an antioxidant, 0.02-0.04 parts of a preservative and 0.05-0.1 parts of a solubilizer. The externally-used gel preparation for treating erythromelalgia has the functions of shrinking blood vessels and reducing the vascular permeability, can also relieve pain and resist inflammation and bacteria and can remarkably relieve redness, swelling, heat and pain of lower limbs in a short period of time; the externally-used gel preparation which is locally applied is prepared from the medicines, the absorption and utilization rate of the preparation is high, the safety is also higher, and clinical experiments show that the externally-used gel preparation has a good curative effect.

The invention discloses a method for determining the dissolution rate of five components in compound reserpine tablets through ultra-performance liquid chromatography, and relates to the field of analytic chemistry. The method comprises the steps that gradient elution is performed on a mobile phase composed of a mobile phase A and a mobile phase B; the mobile phase A is a water solution containinghexanesulfonate, wherein the concentration of the hexanesulfonate is 0.05-0.1%, and pH is 2.5-3.0; the mobile phase B is a mixing solution of methyl alcohol and acetonitrile, and the volume ratio ofmethyl alcohol to acetonitrile is (4.5-5.5):1; peaks can be effectively separated out from the five components of vitamin B1, vitamin B6, hydrochlorothiazide, dihydralazine sulfate and promethazine hydrochloride in the compound reserpine tablets, the number of theoretical plates and the separation degree meet the requirements, the separation effect is obvious, and the dissolution rate of five components in compound reserpine tablets can be determined; the method has the advantages of being simple, rapid, high in sensitivity, good in selectivity and the like.

The invention relates to a preparation method of beta-cyclodextrin (CD) / carbon nanotube (MWNTs) modified electrode and an application of modified electrode in determination of promethazine hydrochloride. The beta-cyclodextrin / carbon nanotube modified electrode can be used for determining promethazine hydrochloride content in a medicine sample.