Compound reserpine orally disintegrating tablet for treating hypertension and preparation method of compound reserpine orally disintegrating tablet

Abstract

The invention belongs to the field of pharmacy, and particularly relates to a compound reserpine orally disintegrating tablet for treating hypertension and a preparation method of the compound reserpine orally disintegrating tablet. The compound reserpine orally disintegrating tablet is prepared from the following raw and auxiliary materials in parts by weight: 0.03 part of reserpine, 1 part of hydralazine hydrochloride, 0.025 part of cyclopenthiazide, 1.5 parts of hydrochlorothiazide, 2 parts of promethazine hydrochloride, 30 parts of potassium chloride, 5 parts of rutin, 2.5 parts of phosphate chloroquine, 1 part of vitamin B1, 1 part of vitamin B6, 2-10 parts of a stabilizer fumaric acid and other pharmaceutical adjuvants. An experiment result shows that the orally disintegrating tablet is short in onset time, long in medicine duration time, and convenient for treatment of a patient for a long period of time; the medication safety is improved; meanwhile, the prescription is high in process stability, and is free of effects of environmental temperature and humidity; and the difference between batches of the preparations is significantly reduced; and the stability of a sample is improved.

Description

technical field [0001] The invention relates to pharmaceutical preparation technology in the pharmaceutical field, in particular to a compound reserpine orally disintegrating tablet for treating hypertension and a preparation method thereof. Background technique [0002] Reserpine is an adrenergic neuron-blocking antihypertensive drug, which achieves antihypertension, slows heart rate and inhibits blood pressure by depleting adrenaline at peripheral sympathetic nerve endings, catecholamines and serotonin in heart, brain and other tissues. The role of the central nervous system. Widely used in the treatment of mild and moderate hypertension; antihypertensive and stable drugs, the antihypertensive effect is slow, but the effect is long-lasting, and the effect disappears slowly after stopping the drug, especially when combined with thiazide diuretics, it has a good effect , is one of the main components of commonly used compound antihypertensive drugs. Hyalalazine hydrochlori...

AI Technical Summary

Problems solved by technology

However, orally disintegrating tablets often have the following disadvantages: problems with the taste of the drug, such as gritty feeling; packaging and transportation problems caused by too low hardness

[0007] In the treatment of hypertension, conventional antihypertensive drugs have large blood pressure fluctuations in the process of reducing blood pressure in hypertension, poor drug treatment effect, large side effects, long onset time, and short drug effect duration

In addition, in the formula of compound reserpine orally disintegrating tablets, the contents of reserpine and pentathiazide are extremely low, which is more than 30 times different from other active ingredients with lower contents, and thousands of times different from other active ingredients with higher contents. times, it is very easy to cause the content uniformity of the drug to not meet the regulations. Through appropriate methods, the drug content uniformity of the active ingredient can be improved to obtain the compound reserpine orally disintegrating tablet preparation that all indicators meet the requirements.

Images