Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Promethazine hydrochloride tablet and preparation method thereof

A promethazine hydrochloride tablet and a promethazine hydrochloride technology are applied in the directions of anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., which can solve the problem of uneven content uniformity of active ingredients, save dosage and cost, and achieve compressibility. Good, compliance-increasing effect

Active Publication Date: 2015-06-03
常州康普药业有限公司
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: in the common promethazine hydrochloride tablet in the prior art, the active ingredient content uniformity is not high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Promethazine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Preparation of solid dispersion carrier: Add 20 g of Poloxamer 407 and 85 g of PEG6000 into 60% (ml / ml) ethanol of 1 / 3 of the prescription amount, heat and stir until Poloxamer 407 and PEG6000 are completely dissolved That is, the auxiliary material solution is obtained;

[0018] Promethazine hydrochloride (dry, pure) 250g is dissolved in 60% (ml / ml) ethanol of recipe quantity 1 / 3 to obtain main drug solution; Gained adjuvant solution and main drug solution are mixed uniformly to obtain mixed solution; Gained mixing The solution is dried in vacuum until the water content is less than 1% (mass percentage);

[0019] (2) Preparation of tablet: pulverize the material obtained in step (1) to 100 mesh to obtain a solid dispersion powder; put the gained solid dispersion powder, starch 180g, and microcrystalline cellulose 360g into a granulator, and dry mix Evenly, add 60% (ml / ml) ethanol of the remaining 1 / 3 of the prescription amount as a binder, set the shearing knife f...

Embodiment 2

[0021] (1) Preparation of solid dispersion carrier, add poloxamer 407 25g and PEG6000 80g into 60% (ml / ml) ethanol of 1 / 3 of the prescription amount, heat and stir until poloxamer and PVPk30 are completely dissolved Yes, excipient solution;

[0022] Promethazine hydrochloride (dry, pure) 250g is dissolved in 60% (ml / ml) ethanol of recipe quantity 1 / 3 to obtain main drug solution; Gained adjuvant solution and main drug solution are mixed uniformly to obtain mixed solution; Gained mixing The solution is dried in vacuum until the water content is less than 1% (mass percentage);

[0023] (2) Preparation of tablet: pulverize the material obtained in step (1) to 120 mesh to obtain solid dispersion powder; put the gained solid dispersion powder, starch 180g, and microcrystalline cellulose 360g into a granulator, and dry mix Evenly, add 60% (ml / ml) ethanol of the remaining 1 / 3 of the prescription amount as a binder, set the frequency of the shearing knife as 30 Hz, and shear and gran...

Embodiment 1、2

[0034] Embodiment 1, 2, and the outward appearance of product in each comparative example, content uniformity are as shown in table 1 (check by Chinese Pharmacopoeia 2010 editions)

[0035] Table 1

[0036]

[0037] (Dissolution is tested according to the standards in Appendix XC of Part Two of the Chinese Pharmacopoeia 2010 Edition).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of medicine preparation, and in particular relates to a promethazine hydrochloride tablet and a preparation method thereof. The preparation method comprises the following steps: firstly, weighing poloxamer and PEG6000 to prepare an auxiliary solution, further preparing a main medicine solution from an effective component promethazine hydrochloride, and uniformly mixing the auxiliary solution and the main medicine solution, thereby obtaining a mixed solution; performing vacuum drying on the mixed solution; crushing the obtained solid material, adding other excipient, putting into a granulator for shearing and granulation, and putting into a boiling dryer for drying; screening and shaping the dried granules, mixing the obtained granules and a lubricant of the formula, and subsequently tabletting.

Description

technical field [0001] The invention belongs to the field of medicine preparation, in particular to a preparation method of promethazine hydrochloride tablet. Background technique [0002] Promethazine hydrochloride tablet is a tablet-type drug with promethazine hydrochloride as the main component. Applicable symptoms ① Skin and mucous membrane allergy: long-term, seasonal allergic rhinitis, vasomotor rhinitis, contact with allergens or food Allergic conjunctivitis, urticaria, angioneurotic edema, allergic reaction to blood or plasma products, skin scratches; ② Motion sickness: motion sickness, seasickness, and airplane sickness. ③Sedation and hypnosis: suitable for preoperative, postoperative and obstetrics. In addition, it can also be used to reduce the fear of adults and children, showing a light sleep state. ④Treatment of nausea and vomiting: It is suitable for nausea and vomiting after some anesthesia and surgery, and is also used to prevent radiation sickness or drug...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/5415A61K47/10A61P37/08A61P11/02A61P27/02A61P17/00A61P9/00A61P1/08A61P25/20A61P29/00
Inventor 王苏南汤金春
Owner 常州康普药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com