Compound antihypertensive drug and preparation method thereof

A drug and compound technology, applied in the field of compound antihypertensive drugs and its preparation, can solve the problems of long onset time, short drug effect duration, and large blood pressure fluctuations

Active Publication Date: 2009-10-07
SHENZHEN OASIS PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of hypertension, conventional antihypertensive drugs have large blood pressure fluctuations in the process of reducing blood pressure in hypertension, poor drug treatment effect, large side effects, long onset time, and short drug effect duration

Method used

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  • Compound antihypertensive drug and preparation method thereof
  • Compound antihypertensive drug and preparation method thereof
  • Compound antihypertensive drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The medicine of the present invention is prepared by the following raw materials according to the weight: hydrochlorothiazide 2g, dihydralazine sulfate 1.5g, promethazine hydrochloride 2g, rutin 5g, chloroquine phosphate 2.5g, potassium chloride 30g, sulfur hydrochloride Amine g, pyridoxine hydrochloride 1g, reserpine 0.03g, magnesium trisilicate 30g, starch 3.57g, magnesium stearate 0.4g, starch slurry 20g.

[0078] It is prepared into tablets as follows:

[0079] Dihydralazine sulfate, reserpine, hydrochlorothiazide, promethazine hydrochloride, rutin, chloroquine phosphate, potassium chloride, thiamine hydrochloride, pyridoxine hydrochloride, magnesium trisilicate, and starch were added to the wet method according to the stated weight. Mix in the granulator; slowly add the starch slurry in said parts by weight into the wet granulator, the starch content in the starch slurry is 2-10%; stir for 10--60 minutes while adding to make a suitable The granules are then dried....

Embodiment 2

[0081] The medicine of the present invention is prepared by the following raw materials according to the weight: hydrochlorothiazide 2g, dihydralazine sulfate 1.5g, promethazine hydrochloride 2g, rutin 5g, chloroquine phosphate 2.5g, potassium chloride 30g, sulfur hydrochloride Amine g, pyridoxine hydrochloride 1g, reserpine 0.03g, magnesium trisilicate 30g, starch 2g, magnesium stearate 0.1g, starch slurry 10g.

[0082] Its preparation method is with embodiment 1.

Embodiment 3

[0084] The medicine of the present invention is prepared by the following raw materials according to the weight: hydrochlorothiazide 2g, dihydralazine sulfate 1.5g, promethazine hydrochloride 2g, rutin 5g, chloroquine phosphate 2.5g, potassium chloride 30g, sulfur hydrochloride Amine g, pyridoxine hydrochloride 1g, reserpine 0.03g, magnesium trisilicate 30g, starch 5g, magnesium stearate 0.8g, starch slurry 30g.

[0085] Its preparation method is with embodiment 1.

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Abstract

The invention discloses a compound drug, particularly relating to a compound antihypertensive drug and a preparation method thereof and belonging to the field of medicine technology. The compound antihypertensive drug is prepared by the following bulk drugs according to parts by weight: 2 parts of hydrochlorothiazide, 1.5 parts of dihydralazine sulfate, 2 parts of promethazine hydrochloride, 5 parts of rutin, 2.5 parts of chloroquine phosphate, 30 parts of potassium chloride, 1 part of thiamine hydrochloride, 1 part of pyridoxin hydrochloride, 0.03 part of reserpine, 30 parts of magnesium trisilicate, 2 to 5 parts of starch, 0.1 to 0.8 part of magnesium stearate and 10 to 30 parts of starch slurry. The compound antihypertensive drug generates low fluctuation of blood pressure in the process of reducing blood pressure for hypertension and the compound antihypertensive drug is also characterized by excellent treatment effect, low side effect, high treatment efficiency and long-lasting drug effect.

Description

technical field [0001] The invention relates to a compound medicine, in particular to a compound antihypertensive medicine and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Hypertension is a clinical syndrome characterized by elevated systemic arterial systolic blood pressure (SBP) and diastolic blood pressure (DBP), and it is currently one of the most common and important clinical cardiovascular diseases. With the continuous improvement of people's living standards, the prevalence of hypertension is also increasing year by year. Hypertension is a clinical syndrome mainly manifested by sustained increase in systemic arterial blood pressure. The cause of hypertension is unknown, called essential hypertension, accounting for more than 95% of total hypertensive patients. Secondary hypertension is high blood pressure secondary to kidney, endocrine and nervous system diseases. Most of them are temporary. After the pri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K47/36A61P9/12A61K31/20A61K31/4415A61K31/475A61K31/502A61K31/51A61K31/5415A61K31/549A61K31/661A61K31/718A61K33/12
Inventor 赖福平
Owner SHENZHEN OASIS PHARMA
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