Novel method for detecting promethazine hydrochloride

A technology of promethazine hydrochloride and modified electrodes, which is applied in the field of electrochemical analysis and detection, can solve the problems of slow electrode reaction, low sensitivity, and large overpotential, and achieve the effects of increased peak current, low analysis cost, and reliable measurement results

Inactive Publication Date: 2015-05-27
大连杰信生物科技有限公司
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  • Abstract
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Problems solved by technology

Yet when adopting electrochemical method, the overpotential of promethazine hydrochloride on the unmodified solid electrode is bigger, and electrode reaction is slow, and sensitivity is lower, so the electrochemical behavior of promethazine hydrochloride is being researched by chemically modified electrode method at present. attention

Method used

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  • Novel method for detecting promethazine hydrochloride
  • Novel method for detecting promethazine hydrochloride
  • Novel method for detecting promethazine hydrochloride

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Experimental program
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Embodiment 1

[0027] 1 Glassy carbon electrode pretreatment

[0028] Put the glassy carbon electrode on metallographic sandpaper (3000 # ), and then sequentially applied 1.0, 0.3 and 0.05 μm Al on the suede pad 2 o 3 Powder polishing, finally with twice distilled water, HNO 3 (1+1), ultrasonic cleaning with absolute ethanol and double distilled water for 3 minutes each. Place the treated glassy carbon electrode in 0.5mol / L H 2 SO 4 In the solution, at a scanning speed of 50mV / s, cycle scanning in the potential range of -0.5 ~ +1.4V until there is no peak. After taking out the electrode, rinse it with double distilled water. After the glassy carbon electrode is treated, its surface has reached the requirements of cleaning and activation. Finally, the cleaned electrodes were stored in double distilled water for later use.

[0029] 2 Preparation of β-cyclodextrin / multi-walled carbon nanotubes modified electrode

[0030] With GC as the base electrode, at 5×10 -3 mol / L β-CD +0.5mol / L H ...

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Abstract

The invention relates to a preparation method of beta-cyclodextrin (CD) / carbon nanotube (MWNTs) modified electrode and an application of modified electrode in determination of promethazine hydrochloride. The beta-cyclodextrin / carbon nanotube modified electrode can be used for determining promethazine hydrochloride content in a medicine sample.

Description

technical field [0001] The invention relates to the technical field of electrochemical analysis and detection, in particular to a preparation method of a multi-walled carbon nanotube glassy carbon electrode modified by β-cyclodextrin and its application in the determination of the active ingredient content of promethazine hydrochloride. [0002] Background technique [0003] Promethazine Hydrochlorine (PTH), also known as promethazine hydrochloride, can competitively block histamine H1 receptors to produce antihistamine effects, has strong anti-allergic and significant central stabilizing effects, and can Enhances the effects of narcotics and analgesics. At present, methods for the determination of promethazine hydrochloride include spectrophotometry, fluorescence photometry, flow injection analysis, resonance light scattering, capillary electrophoresis, and liquid chromatography. Most of these methods involve expensive instruments and complicated operations. The electroc...

Claims

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Application Information

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IPC IPC(8): G01N27/48G01N27/30
Inventor 申贵隽李东霞李珂珂
Owner 大连杰信生物科技有限公司
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