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Prescription of compound bendazol and hydrochlorothiazide capsule and its preparation process

A technology for azole hydrochlorothiazide and production technology, which is applied to the formulation of compound diprazol and hydrochlorothiazide capsules and the field of production technology, can solve the problems of inability to batch and produce, complex formula, chemical instability, etc. Even, avoid mutual influence effect

Active Publication Date: 2006-02-08
FUZHOU CHENXING PHARMA
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0002] Compound dipazole hydrochlorothiazide capsule is a kind of antihypertensive drug. Its traditional formula is relatively complicated. There are 12 kinds of chemical raw materials. Only a few tenths of a milligram are used in capsules, so it is not possible to use general wet granulation for granulation and mixing, nor can it be used for batching and production under normal production conditions; These deficiencies have led to the uncertainty of product quality and curative effect of compound dimethazol hydrochlorothiazide capsules produced by many manufacturers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] (1) Formula: dimethazole 10kg, promethazine hydrochloride 3.6kg, chloroquine phosphate 3.0kg, guanidine sulfate 1.44kg, vitamin B 6 1.2kg, potassium chloride 36kg, reserpine 0.36kg, chlordiazepoxide 2.4kg, hydrochlorothiazide 3.6kg, calcium lactate 1.2kg, vitamin B 1 1.2kg, 36kg of magnesium trisilicate, appropriate amount of medicinal starch;

[0009] (2) According to the following process:

[0010] ① Dissolve 1.2kg of calcium lactate, 36kg of potassium chloride and 40L of water to make solution A; take 5kg of starch and add water to 50L, stir evenly, add solution A, boil to make a uniform 10% composite starch slurry B;

[0011] ②Crush magnesium trisilicate and pass through 80 meshes, weigh 36kg and mix it with 198.33kg of medicinal starch according to the method of equal increase, and mix evenly to obtain mixed powder C, then add 10% composite starch slurry, stir evenly, and cut to make Granules, boiled and dried below 60°C until the water content is less than 3.0%,...

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PUM

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Abstract

The invention relates to a compound dibazole and hydrochlorothiazidum capsule and process for preparation, wherein the raw materials include dibazole, promethazine, chloroquine phosphate, guanoxan sulfate, vitamin B6, potassium chloride, crystoserpine, hydrochlorothiazidum, calcium lactate, vitamin B1, magnesium trisilicate and medicinal starch. The end product can effectively lower blood pressure.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a formula of compound dipazole hydrochlorothiazide capsules and a production process thereof. technical background [0002] Compound dipazole hydrochlorothiazide capsule is a kind of antihypertensive drug. Its traditional formula is relatively complicated. There are 12 kinds of chemical raw materials. Only a few tenths of a milligram are used in capsules, so it is not possible to use general wet granulation for granulation and mixing, nor can it be used for batching and production under normal production conditions; These deficiencies have just led to the uncertainty of product quality and curative effect of compound dimethazol hydrochlorothiazide capsules produced by many manufacturers. Contents of the invention [0003] The object of the present invention is to provide a formula of compound dipazole hydrochlorothiazide capsule and its production process. The finished product prepared...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5415A61K9/48A61P9/12
Inventor 董惠芳
Owner FUZHOU CHENXING PHARMA
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