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High stability composite guaiacol phenolsulfonic acid oral liquid and preparation method thereof

A technology of potassium guaiacol sulfonate and lignosulfonic acid, which is applied in the field of pharmacy, can solve the problems of unstable properties, easy oxidative discoloration, unstable drugs, etc., so as to improve stability, ensure safety, and ensure stability Effect

Inactive Publication Date: 2013-06-12
广东南国药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, because promethazine hydrochloride belongs to phenothiazine drugs, its properties are unstable, it is easy to oxidize and change color, and it turns blue when it is exposed to air and moisture for a long time, which makes the drug unstable and affects the use effect of patients.

Method used

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  • High stability composite guaiacol phenolsulfonic acid oral liquid and preparation method thereof
  • High stability composite guaiacol phenolsulfonic acid oral liquid and preparation method thereof
  • High stability composite guaiacol phenolsulfonic acid oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 A kind of highly stable compound guaiacol sulfonic acid oral solution and preparation method thereof

[0023] (1) Accurately weigh raw materials according to the content of the following components:

[0024] Promethazine hydrochloride 0.05% (m / v), potassium guaiacol sulfonate 0.012% (m / v), ammonium chloride 0.04% (m / v), sodium citrate 0.20% (m / v), Citric acid 0.03% (m / v), benzoic acid 0.13% (m / v), ethylparaben 0.02% (m / v), sucrose 20% (m / v), caramel 0.01% (m / v) ), vitamin C 0.2% (m / v), lychee essence 0.02 (v / v), banana essence 0.1 (v / v), ethanol amount, and the balance is purified water;

[0025] (2) Boil and dissolve the sucrose with an appropriate amount of purified water, then filter and set aside;

[0026] (3) After completely dissolving ammonium chloride, potassium guaiacol sulfonate, sodium citrate, and citric acid with an appropriate amount of purified water, add them to the sugar solution and mix well;

[0027] (4) Dissolve benzoic acid and ethylp...

Embodiment 2

[0028] Example 2 A kind of highly stable compound guaiacol sulfonic acid oral solution and preparation method thereof

[0029] (1) Accurately weigh raw materials according to the content of the following components:

[0030] Promethazine hydrochloride 0.06% (m / v), Potassium guaiacol sulfonate 0.013% (m / v), Ammonium chloride 0.06% (m / v), Sodium citrate 0.30% (m / v), Citric acid 0.04% (m / v), benzoic acid 0.14% (m / v), ethylparaben 0.04% (m / v), sucrose 30% (m / v), caramel 0.02% (m / v ), vitamin C 0.3% (m / v), lychee essence 0.04 (v / v), banana essence 0.2 (v / v), ethanol amount, and the balance is purified water;

[0031] (2) Boil and dissolve the sucrose with an appropriate amount of purified water, then filter and set aside;

[0032] (3) After completely dissolving ammonium chloride, potassium guaiacol sulfonate, sodium citrate, and citric acid with an appropriate amount of purified water, add them to the sugar solution and mix well;

[0033] (4) Dissolve benzoic acid and ethylpa...

Embodiment 3

[0034] Example 3 A kind of highly stable compound guaiacol sulfonic acid oral solution and preparation method thereof

[0035] (1) Accurately weigh raw materials according to the content of the following components:

[0036]Promethazine hydrochloride 0.055% (m / v), potassium guaiacol sulfonate 0.0125% (m / v), ammonium chloride 0.05% (m / v), sodium citrate 0.25% (m / v), Citric acid 0.035% (m / v), benzoic acid 0.135% (m / v), ethylparaben 0.03% (m / v), sucrose 25% (m / v), caramel 0.015% (m / v) ), vitamin C 0.25% (m / v), lychee essence 0.025 (v / v), banana essence 0.15 (v / v), ethanol in proper amount, and the balance is purified water;

[0037] (2) Boil and dissolve the sucrose with an appropriate amount of purified water, then filter and set aside;

[0038] (3) After completely dissolving ammonium chloride, potassium guaiacol sulfonate, sodium citrate, and citric acid with an appropriate amount of purified water, add them to the sugar solution and mix well;

[0039] (4) Dissolve benzoi...

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PUM

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Abstract

The invention relates to a high stability composite guaiacol phenolsulfonic acid oral liquid and a preparation method thereof, and belongs to the technical field of pharmaceutics. The oral liquid is prepared by adopting promethazine hydrochloride, guaiacol phenolsulfonic acid, ammonium chloride, sodium citrate, benzoic acid, ethylparaben, cane sugar, caramel, Litchi chinensis essence and banana essence as raw and auxiliary materials, adding an antioxidant cysteine hydrochloride or vitamin C and adopting ethanol and water as a solvent. According to the invention, deficiencies of conventional formula are improved, and the antioxidant is added to effectively prevent promethazine hydrochloride form being oxidized. The guaiacol phenolsulfonic acid oral liquid prepared by the formula and process is high in stability in the placing process, so that the medicine quality and medication safety of patients can be effectively ensured.

Description

technical field [0001] The invention relates to an oral liquid and a preparation method thereof, in particular to a highly stable compound guaiacol sulfonic acid oral liquid and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Compound guaiacol sulfonic acid oral solution belongs to oral solution, is a commonly used drug, and is mostly used clinically for cough and phlegm caused by cold and allergic bronchitis. Its prescription contains dozens of ingredients such as ammonium chloride, potassium guaiacol sulfonate, and promethazine hydrochloride. [0003] Due to the chemical stimulation of the mucous membrane, ammonium chloride reflexively increases the amount of sputum and makes the sputum easy to discharge, so it is beneficial to the removal of a small amount of sticky sputum that is difficult to cough up. After this product is absorbed, chloride ions enter the blood and extracellular fluid to acidify the urine and correct met...

Claims

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Application Information

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IPC IPC(8): A61K33/20A61K9/08A61K47/26A61K47/22A61K47/18A61P11/00A61P11/14A61K31/5415A61K31/185
Inventor 庞华兴白玉春贺登科
Owner 广东南国药业有限公司
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