A kind of promethazine hydrochloride tablet and preparation method thereof

A technology of promethazine hydrochloride tablets and promethazine hydrochloride, which is applied in medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., can solve the pain, difficulty of carrying, and compliance of injections To achieve the effect of increasing compliance, improving taste, and simplifying prescriptions

Active Publication Date: 2019-11-12
常州康普药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms of promethazine hydrochloride listed at home and abroad mainly include tablets, injections, and oral and nasal sprays. However, the above dosage forms have limitations, such as tablets, especially children, are difficult to swallow; injections are painful. Sensitive and difficult to self-administer, poor compliance, not easy to carry

Method used

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  • A kind of promethazine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Add 150mL ethanol to 150mL deionized water to make a uniform solution, and divide the resulting solution into three parts on average;

[0023] (2) Add 60g of Poloxamer 407 and 40g of PEG4000 to one of the solutions prepared in step (1), heat to 60°C and stir thoroughly to obtain a dispersion of excipients;

[0024] (3) 260g promethazine hydrochloride is added in another wherein a solution prepared in step (1), fully stirred to obtain the main material dispersion;

[0025] (4) fully mixing the auxiliary material dispersion obtained in step (2) and the main material dispersion obtained in step (3), and vacuum drying until the moisture content of the mixture is less than 1% (mass percentage);

[0026] (5) Grind the dried material in step (4) to 100-120 meshes, and mix it with 35g stevioside, 260g starch, and 260g microcrystalline cellulose in a granulator, and add it to step (1) For the remaining part of the solution prepared, set the frequency of the shearing knife t...

Embodiment 2

[0028] (1) Add 180mL ethanol to 120mL deionized water to make a uniform solution, and divide the obtained solution into three parts on average;

[0029] (2) Add 100g of PEG6000 to one of the solutions prepared in step (1), heat to 60°C and stir thoroughly to obtain a dispersion of excipients;

[0030] (3) 240g promethazine hydrochloride is added in another one of the solutions prepared in step (1), fully stirred to obtain the main material dispersion;

[0031] (4) fully mixing the auxiliary material dispersion obtained in step (2) and the main material dispersion obtained in step (3), and vacuum drying until the moisture content of the mixture is less than 1% (mass percentage);

[0032] (5) Grind the dried material in step (4) to 100-120 meshes, put it into a granulator with 30g of stevioside, 200g of starch, and 300g of microcrystalline cellulose and mix well, and add it to step (1) For the remaining part of the solution prepared, set the frequency of the shearing knife to 2...

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Abstract

The invention belongs to the technical fields of medicines and medicine production, and in particular relates to a promethazine hydrochloride tablet and a preparation method thereof. On the basis of selecting related adjuvants and carriers, the tablet, by combining stevioside and promethazine hydrochloride, is quite ideal in formability and disintegrating performance; and meanwhile, a formula is also further simplified.

Description

technical field [0001] The invention belongs to the technical field of medicine and medicine production, in particular to a promethazine hydrochloride tablet and a preparation method thereof. Background technique [0002] The main effects of promethazine hydrochloride are: anti-inflammation and anti-allergy to skin and mucous membrane allergies, rhinitis, conjunctivitis, urticaria, angioedema; treatment of motion sickness, seasickness, and airplane sickness; sedation, hypnosis, and alleviating the fear of adults and children Sensation; treatment of nausea and vomiting, especially after some anesthesia and surgery or radiation sickness or drug-induced nausea and vomiting; postoperative pain. [0003] At present, the dosage forms of promethazine hydrochloride listed at home and abroad mainly include tablets, injections, and oral and nasal sprays. However, the above dosage forms have limitations, such as tablets, especially children, are difficult to swallow; injections are pai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/10A61K31/5415A61P37/08A61P29/00A61P1/08A61P25/20
CPCA61K9/2018A61K9/2031A61K31/5415
Inventor 王苏南
Owner 常州康普药业有限公司
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