Taxane medicines albumin nanoparticle preparation for injection and preparation method thereof
A technology of albumin nanoparticles and taxanes, which is applied in the field of taxane drug albumin nanoparticle preparations for injection and its preparation. Sex and other issues, to achieve good clinical application prospects, improve anti-tumor effect, reduce the effect of dosage
Active Publication Date: 2012-11-21
FUDAN UNIV
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The invention belongs to the field of medicinal preparation, and relates to taxane medicines albumin nanoparticle preparation for injection and a preparation method of the preparation. According to the invention, the albumin nanoparticle preparation is prepared by combining the albumin with the taxane medicines to form the albumin nanoparticles by dispersing and stabilizing with the phospholipid. According to the invention, the strengthened osmosis and retention effect on the tumors by the nanoparticles are utilized, and more medicines are passively targeted and concentrated on the tumor tissues so as to improve the antitumor effect; simultaneously, due to the fact that the bioavailability in the injection way is high and the soluble albumin nanoparticle preparation for injection exists passive targeting, the administration dose can be greatly reduced, so that the medicinal concentration on the non-target parts can be effectively reduced, the toxic and side effects of the medicines can be reduced, and the good clinical application prospect can be implemented. The preparation is convenient in preparation method and is suitable for industrial mass production.
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