9 results about "Furanocoumarin" patented technology

The present invention relates to the use of a mixture of water and an essential oil selected from phenolic, phenylpropanoid and furanocoumarin for separating multilayer composites in order to sort the polymer films or metal films.

The application discloses a method for constructing a characteristic map of a traditional Chinese medicine and the characteristic map, wherein the method adopts an HPLC method to determine the content of an effective component, imperatorin, in Zhikang capsules, and constructs a high performance liquid chromatography characteristic map of the Zhikang capsules; 10 characteristic peaks are determined as the characteristic map, which are respectively from dragon's blood, rhubarb and Bai Zhi; the components from the dragon's blood are dracorhodin B (peak 2) and pterostilbene (peak 4); the components from the rhubarb are peak 1 (aloe-emodin), peak 3, peak 6 (emodin), peak 9 and peak 10; and the components from the Bai Zhi are imperatorin (peak 5), peak 7 and peak 8; the method covers polyphenols, anthraquinones and furanocoumarins and other main components, and constructs a quality evaluation system of the Zhikang capsules; the method has good specificity, precision, repeatability and solution stability, and can be used for standardizing the production of the Zhikang capsules and guaranteeing the uniformity and stability of the internal quality of products to provide comprehensive quality control.

The application relates to application of a furan coumarin compound shown in a formula I to prevention and / or treatment of a nervous system disease related to neuroinflammation. The furan coumarin compound has a protective effect on normoxia + lipopolysaccharide (LPS) and hypoxia + LPS combined induction of mouse stellate glial C8-D1A cell normoxia and hypoxia neuroinflammation models, can promote cell growth, inhibit production of related inflammatory factors, effectively reduce brain water content production, weight loss and key protein expression of a plateau cerebral edema model mouse, and can be developed into a medicine for preventing and / or treating neuroinflammation related diseases.

The application discloses a furan coumarin compound and a preparation method and application thereof, and the molecular formula of the furan coumarin compound is C 21 H 20 O6; the furan coumarin compound can reduce the inflammatory reaction of RAW264.7 macrophages induced by lipopolysaccharide (LPS), can reduce the NO production of RAW264.7 macrophages induced by LPS, and can significantly inhibit the production of inflammatory factors such as TNF-alpha, interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta).

The application discloses a furan coumarin compound and application thereof in preparation of a drug for treating osteoporosis, and belongs to the technical field of drug research and development. 50 The furan coumarin compound has an IC of 37.86 nM, has no obvious cytotoxicity and systemic toxicity, can inhibit a key path of RANKL-induced osteoclast differentiation, and can be used for preparing the drug for treating osteoporosis.

This invention discloses a protein with O-isopentenyltransferase activity, related biomaterials, and applications, belonging to the field of biotechnology. This invention screened and cloned an O-isopentenyltransferase gene (GlOPT), which can be used to prepare O-isopentenyltransferase. Experiments have confirmed that this O-isopentenyltransferase can catalyze the in vitro conversion of 8-hydroxybergamot lactone to arugulatin; catalyze the conversion of bergamotol to isoimperatorin; and catalyze the conversion of xanthotoxin to imperatorin. This provides technical support for the production of isopentenyl furanocoumarin-like active ingredients from arugula, lays the foundation for research on the biosynthetic pathways of coumarin compounds, and has significant theoretical and practical implications.

This application discloses an epoxide hydrolase gene cloned from Angelica dahurica. AdEH1 and AdEH2 and its encoded proteins and applications, among which, AdEH 1 and AdEH2 The nucleotide sequences are shown in SEQ ID NO: 1 and SEQ ID NO: 2, respectively, and the amino acid sequences encoding the proteins are shown in SEQ ID NO: 3 and SEQ ID NO: 4, respectively. AdEH1 and AdEH2 The encoded protein possesses epoxide hydrolase catalytic activity, capable of catalyzing the oxidation of imperatorin and angelica root to produce hydrated oxidized imperatorin and angelica root. This application identifies the gene. AdEH1 and AdEH2 Its key role in the biosynthesis of furanocoumarins provides core gene resources for the regulation and green large-scale synthesis of furanocoumarin components in Angelica dahurica, and also provides technical support for the accurate detection of related compounds.

The invention belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to a furocoumarin compound as well as a preparation method and application thereof. The furocoumarin compound provided by the invention has a structure as shown in a formula I. The furocoumarin compound provided by the invention can inhibit the release of inflammatory factors, has an anti-oxidation effect, and also can inhibit NF-kappa B and MAPK signal pathways, so that the furocoumarin compound plays an anti-inflammatory role and is used for preparing anti-inflammatory drugs. Moreover, the furocoumarin compound is extracted from radix angelicae, the source is natural, and the preparation method is simple and efficient. Formula I

The application belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to a furanocoumarin compound, a preparation method and application thereof. The furanocoumarin compound provided by the application has a structure shown in formula I. The furanocoumarin compound provided by the application can inhibit the release of inflammatory factors, has an antioxidation effect, can inhibit the NF-kappa B and MAPK signal pathways, thereby playing an anti-inflammatory role, and is used for preparing anti-inflammatory drugs. Moreover, the furanocoumarin compound is extracted from radix angelicae dahuricae, is natural in origin, and is simple and efficient in the preparation method. Formula I.