16 results about "Furanocoumarin" patented technology

The application discloses a kind of chiral dihydrofuranocoumarin compounds, its synthesis method and application, belong to organic chemistry synthesis and medical field;The structure of the compound is with C3 position amino methyl substitution chiral center dihydrofuranocoumarin as skeleton, its synthesis method is: at room temperature, copper salt and chiral ligand (L) are dissolved in organic solvent and stirred, then 4-ethynyl cyclic carbamic acid ester (I), 4-hydroxycoumarin (II) are sequentially added, after stirring reaction is completed, direct separation and purification are obtained;The compound provided by the application can be efficiently converted into other novel furanocoumarin compounds by simple reaction, and has good potential application value in antitumor drug research;The synthesis method of the application has the advantages of novelty, simple operation, mild reaction condition, good substrate universality, high yield, high stereoselectivity and the like.

The present invention relates to the use of a mixture of water and an essential oil selected from phenolic, phenylpropanoid and furanocoumarin for separating multilayer composites in order to sort the polymer films or metal films.

The application discloses a method for constructing a characteristic map of a traditional Chinese medicine and the characteristic map, wherein the method adopts an HPLC method to determine the content of an effective component, imperatorin, in Zhikang capsules, and constructs a high performance liquid chromatography characteristic map of the Zhikang capsules; 10 characteristic peaks are determined as the characteristic map, which are respectively from dragon's blood, rhubarb and Bai Zhi; the components from the dragon's blood are dracorhodin B (peak 2) and pterostilbene (peak 4); the components from the rhubarb are peak 1 (aloe-emodin), peak 3, peak 6 (emodin), peak 9 and peak 10; and the components from the Bai Zhi are imperatorin (peak 5), peak 7 and peak 8; the method covers polyphenols, anthraquinones and furanocoumarins and other main components, and constructs a quality evaluation system of the Zhikang capsules; the method has good specificity, precision, repeatability and solution stability, and can be used for standardizing the production of the Zhikang capsules and guaranteeing the uniformity and stability of the internal quality of products to provide comprehensive quality control.

The application relates to application of a furan coumarin compound shown in a formula I to prevention and / or treatment of a nervous system disease related to neuroinflammation. The furan coumarin compound has a protective effect on normoxia + lipopolysaccharide (LPS) and hypoxia + LPS combined induction of mouse stellate glial C8-D1A cell normoxia and hypoxia neuroinflammation models, can promote cell growth, inhibit production of related inflammatory factors, effectively reduce brain water content production, weight loss and key protein expression of a plateau cerebral edema model mouse, and can be developed into a medicine for preventing and / or treating neuroinflammation related diseases.

The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L Ficus carica The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried fruit of fig (L The present application relates to a kind of furan coumarins enantiomers in fig fruit and its preparation method and purposes, the method with the dried

The invention relates to the technical field of fruit and vegetable processing, in particular to a preparation method for reducing the furocoumarin content of citrus juice. The invention provides a preparation method of citrus juice with low furocoumarin content, which comprises the following steps: performing ultraviolet light irradiation treatment on the citrus juice, and the wavelength of ultraviolet light is 320-420nm. According to the method, the ultraviolet light irradiation technology is utilized, the citrus juice is treated by selecting a specific wave band, and the content of various furocoumarin components in the citrus juice subjected to irradiation treatment is obviously reduced.

The application discloses a furan coumarin compound and a preparation method and application thereof, and the molecular formula of the furan coumarin compound is C 21 H 20 O6; the furan coumarin compound can reduce the inflammatory reaction of RAW264.7 macrophages induced by lipopolysaccharide (LPS), can reduce the NO production of RAW264.7 macrophages induced by LPS, and can significantly inhibit the production of inflammatory factors such as TNF-alpha, interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta).

The invention relates to a tea saponin composition with anti-oxidation and whitening effects and application of the tea saponin composition, and belongs to the technical field of cosmetics. The tea saponin composition is prepared from the following components in parts by mass: 3 to 6 parts of tea saponin liquid, 0.5 to 2 parts of roxburgh rose fruit extract and 1 to 3 parts of radix saposhnikoviae extract. The tea saponin provided by the invention realizes improvement of skin feeling and efficacy, improves safety, and can also be used as an emulsifier. By optimizing the process of using tea saponin in cosmetics, other impurity components are reduced. The rosa roxburghii tratt fruit extract is high in antioxidant and whitening activity, and irritation to skin is reduced while the effect of the rosa roxburghii tratt fruit extract is guaranteed. The content of coumarin compounds and furocoumarin structural substances in the radix saposhnikoviae root extract is higher than that of coumarin compounds and furocoumarin structural substances in the radix saposhnikoviae stem extract, and the radix saposhnikoviae root extract has higher light protection and anti-inflammatory activity and is more suitable for forming a moisturizing film. The cosmetic prepared from the tea saponin composition and the preparation method thereof is higher in stability, good in antioxidant and whitening effects and higher in safety.

The invention discloses a synergistic extraction method of active ingredients of pearl powder and radix angelicae dahuricae and application of the active ingredients in tooth whitening. According to the invention, through temperature cycle regulation and control, the eutectic solvent fully permeates gaps of pearl powder particles and cell walls of angelica dahurica when being in a liquid state at 35 DEG C, and polar components are preliminarily dissolved out by using a hydrogen bond network; after the temperature is raised to 55 DEG C to initiate phase change, the coordination effect with calcium carbonate crystal lattices is enhanced while the viscosity of the solvent is reduced, gradual dissolution of inorganic components of the pearl powder is promoted, meanwhile, furocoumarin in cells of radix angelicae and the solvent form specific interaction in the phase change process, and lipid-soluble components are assisted and activated in cooperation with microwaves; synchronous and efficient dissolution of the two active ingredients is realized. A dynamic strengthening mechanism of permeation-dissolution-mass transfer is formed by multiple rounds of heating and cooling circulation, so that the dissolution amount of pearl protein and coumarin components is greatly increased compared with that of traditional solvent extraction, decomposition of photosensitive components of radix angelicae is further reduced under the light-proof condition in the whole process, and the activity retention rate of the extract is high.

The application discloses a furan coumarin compound and application thereof in preparation of a drug for treating osteoporosis, and belongs to the technical field of drug research and development. 50 The furan coumarin compound has an IC of 37.86 nM, has no obvious cytotoxicity and systemic toxicity, can inhibit a key path of RANKL-induced osteoclast differentiation, and can be used for preparing the drug for treating osteoporosis.

The present invention provides a cucurbitacin compound, its preparation method, and application, belonging to the field of pharmaceutical chemistry. The cucurbitacin compound represented by Formula I is extracted and isolated from Scrophularia purpurogenum. This furanocoumarin compound can inhibit the phosphorylation of STAT3 in triple-negative breast cancer cells and further affect the expression of downstream apoptosis-related proteins PARP and Caspase3, promoting apoptosis in triple-negative breast cancer cells, thereby inhibiting the growth of triple-negative breast cancer. It has broad application prospects in the preparation of drugs for the prevention and / or treatment of triple-negative breast cancer. #imgabs0# Formula I.

This invention discloses a protein with O-isopentenyltransferase activity, related biomaterials, and applications, belonging to the field of biotechnology. This invention screened and cloned an O-isopentenyltransferase gene (GlOPT), which can be used to prepare O-isopentenyltransferase. Experiments have confirmed that this O-isopentenyltransferase can catalyze the in vitro conversion of 8-hydroxybergamot lactone to arugulatin; catalyze the conversion of bergamotol to isoimperatorin; and catalyze the conversion of xanthotoxin to imperatorin. This provides technical support for the production of isopentenyl furanocoumarin-like active ingredients from arugula, lays the foundation for research on the biosynthetic pathways of coumarin compounds, and has significant theoretical and practical implications.

This application discloses an epoxide hydrolase gene cloned from Angelica dahurica. AdEH1 and AdEH2 and its encoded proteins and applications, among which, AdEH 1 and AdEH2 The nucleotide sequences are shown in SEQ ID NO: 1 and SEQ ID NO: 2, respectively, and the amino acid sequences encoding the proteins are shown in SEQ ID NO: 3 and SEQ ID NO: 4, respectively. AdEH1 and AdEH2 The encoded protein possesses epoxide hydrolase catalytic activity, capable of catalyzing the oxidation of imperatorin and angelica root to produce hydrated oxidized imperatorin and angelica root. This application identifies the gene. AdEH1 and AdEH2 Its key role in the biosynthesis of furanocoumarins provides core gene resources for the regulation and green large-scale synthesis of furanocoumarin components in Angelica dahurica, and also provides technical support for the accurate detection of related compounds.

The invention belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to a furocoumarin compound as well as a preparation method and application thereof. The furocoumarin compound provided by the invention has a structure as shown in a formula I. The furocoumarin compound provided by the invention can inhibit the release of inflammatory factors, has an anti-oxidation effect, and also can inhibit NF-kappa B and MAPK signal pathways, so that the furocoumarin compound plays an anti-inflammatory role and is used for preparing anti-inflammatory drugs. Moreover, the furocoumarin compound is extracted from radix angelicae, the source is natural, and the preparation method is simple and efficient. Formula I

The invention relates to an application of a group of furocoumarin compounds in preparation of a medicine for inhibiting diseases caused by cell death. The furocoumarin compounds are white angelica, white angelica brain, alloimperatorin, imperatorin, hydrated oxidized imperatorin or decuricin. The invention also provides application of the furocoumarin compound in preparation of an experimental reagent for inhibiting diseases caused by cell death. Experiments show that imperatorin and hydrated oxidized imperatorin can significantly improve the survival rate of influenza lethal model mice. The hydrated oxypeucedanin can significantly reduce the fatality rate of cytokine storm syndrome model mice. The invention illustrates that the furocoumarin compound inhibits cell death, delays or blocks the occurrence of cytokine storm, further reduces the development of acute lung injury or multi-organ function failure, and has considerable clinical application prospects.

The application belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to a furanocoumarin compound, a preparation method and application thereof. The furanocoumarin compound provided by the application has a structure shown in formula I. The furanocoumarin compound provided by the application can inhibit the release of inflammatory factors, has an antioxidation effect, can inhibit the NF-kappa B and MAPK signal pathways, thereby playing an anti-inflammatory role, and is used for preparing anti-inflammatory drugs. Moreover, the furanocoumarin compound is extracted from radix angelicae dahuricae, is natural in origin, and is simple and efficient in the preparation method. Formula I.