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Traditional Chinese medicine composition for preventing and treating dermatomycoses

A fungal skin disease and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of toxic side effects, inability to effectively prevent and treat, high recurrence rate, etc., and achieve the effect of no toxic side effects and significant synergistic effect

Active Publication Date: 2018-09-25
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of fungal skin diseases is still dominated by western medicine, including itraconazole, terbinafine and fluconazole. However, due to the serious side effects of these drugs on the liver and other organs, the interruption of treatment makes the course of treatment not enough. The recurrence rate is abnormally high, and the fungus at the infected site is not killed due to insufficient treatment, and the fungus around the skin lesion is not affected, so once the treatment ends prematurely, the fungus will come back
At present, there are basically no Chinese patent medicines that can effectively prevent and treat this type of disease in the market. Therefore, there is an urgent need for new drugs that can effectively prevent and treat this disease and have low toxicity or no toxicity to go on the market.

Method used

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  • Traditional Chinese medicine composition for preventing and treating dermatomycoses
  • Traditional Chinese medicine composition for preventing and treating dermatomycoses
  • Traditional Chinese medicine composition for preventing and treating dermatomycoses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Zanthoxylum bungeanum extract preparation

[0026] Zanthoxylum bungeanum, crushed into coarse powder, add 4 times the amount (volume) of 95% ethanol, heat and reflux for extraction 3 times, each time for 1 hour, combine the extracts, filter, recover the solvent under reduced pressure at 50°C until there is no alcohol smell, and reduce pressure at 50°C After drying for 24 hours, the Zanthoxylum bungeanum extract was obtained as a brown oil with a yield of 26.4% (g / g).

Embodiment 2

[0027] Embodiment 2 preparation of rattan pepper extract

[0028] Rattan pepper, crushed into coarse powder, added 4 times the amount (volume) of vegetable oil, heated and refluxed to extract 3 times, each time for 1 hour, combined extracts, filtered, and set aside.

Embodiment 3

[0029] Example 3 Sophora flavescens extract preparation ①

[0030] Sophora flavescens, crushed into a coarse powder, add 4 times the amount (volume) of 95% ethanol, heat and reflux for extraction 3 times, each time for 1 hour, combine the extracts, filter, recover the solvent under reduced pressure at 60 ° C until there is no alcohol smell, and reduce it at 60 ° C Press and dry for 24 hours to obtain Sophora flavescens extract ①, which is a brown substance with a yield of 17% (g / g).

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating dermatomycoses. The traditional Chinese medicine composition is prepared by using Sichuan pepper and / or zanthoxylum armatum fruits, radix sophorae flavescentis and veratrum nigrum roots as effective pharmaceutical ingredients, and co-formed with pharmaceutically acceptable auxiliary additive ingredients.According to the parts by weight, a proportion of each ingredient of crude drugs of the Sichuan pepper and / or the zanthoxylum armatum fruits to the radix sophorae flavescentis to the veratrum nigrumroots is (0.01 to 1.0) to (1.0 to 5.0) to (0.3-3). The traditional Chinese medicine composition has the remarkable synergistic interaction effect to the prevention and treatment of the dermatomycoses,especially dermatosis caused by dermatophytes, and apparent toxic and side effects are not existent.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, more specifically, the invention relates to a traditional Chinese medicine composition for preventing and treating fungal skin diseases, especially skin diseases caused by dermatophytes. Background technique [0002] Dermatomycosis is a large category of common skin infectious diseases caused by fungi invading the skin, deck and hair in dermatology. It not only has a high incidence rate, but also has a high recurrence rate. Fungal skin diseases are mainly caused by three major groups of human-friendly pathogenic fungi, including dermatophytosis, Malassezia-related diseases of the skin, and cutaneous candidiasis. Dermatomycosis caused by environmental fungi (including indoor fungi and outdoor fungi) mainly involves deep skin and / or subcutaneous tissue, forming fungal granulomas. [0003] Dermatophyte is a kind of keratinophilic filamentous fungus, and the vast majority of pathogenic ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P17/00A61P31/10
CPCA61K36/489A61K36/758A61K36/896A61K2236/31A61K2236/33A61K2236/333A61K2236/35A61P17/00A61P31/10A61K2300/00
Inventor 谭正怀袁崇均唐大轩罗森熊静悦陈帅刘琪张秀张莉
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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