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Resveratrol oligo cattail compounds, its manufacturing process, pharmaceutical combination and uses thereof

A technology of drugs and ethanol, applied in the fields of drug combination, antipyretic, organic chemistry, etc., can solve the problems of difficulty, difficult separation of compounds in large quantities, and insufficient depth.

Inactive Publication Date: 2007-10-17
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on the in vivo effects of the above active ingredients, and they are not deep enough.
The main reason is that such compounds are not easy to be separated in large quantities, and the obtained trace components can only be used for in vitro tests
If it is prepared by artificial total synthesis, there are certain difficulties at present

Method used

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  • Resveratrol oligo cattail compounds, its manufacturing process, pharmaceutical combination and uses thereof
  • Resveratrol oligo cattail compounds, its manufacturing process, pharmaceutical combination and uses thereof
  • Resveratrol oligo cattail compounds, its manufacturing process, pharmaceutical combination and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1. The preparation of the effective fraction group extract of Dazimaimateng:

[0088] Gnetum Montanum f.megalocarpum (Gnetum Montanum f.megalocarpum) stem 10kg is pulverized, respectively with 5 times the amount, 4 times the amount, 4 times the amount, refluxed with 95% ethanol for 2 hours, extracted 3 times, and concentrated the extract under reduced pressure to obtain a rough extract Cream 874 grams. The crude extract was refluxed with 3 times the amount of petroleum ether to degrease twice, each time for 1 hour, and the degreased extract was refluxed with 3 times the amount of acetone to extract 4 times, each time for 1 hour. Concentrate the acetone-soluble part, mix the sample with 30-60 mesh polyamide according to the multiple of 1:2, pack it into the column at 1:5, and fully elute with 30%-80% ethanol. Collect 30%-80% ethanol and concentrate partly to obtain 44.2g of the effective part extract of Dazimai Mateng.

Embodiment 2

[0089] Example 2. Preparation of gnetumontanin B (gnetumontanin B, 1):

[0090] Dazi bought Gnetum montanum f.megalocarpum stem (10Kg), ground it and extracted it four times with 95% alcohol under reflux, distilled under reduced pressure to remove the solvent, obtained crude extract (870g) Soxhlet extraction, respectively with chloroform, Ethyl acetate, acetone, methanol elution. The ethyl acetate fraction (200g) was further subjected to silica gel column chromatography (140-180 mesh), chloroform-methanol gradient elution (30:1, 20:1, 15:1, 12:1, 10:1, 9:1 , 8:1, 6:1, 5:1, 4:1), divided into eight parts A-H. Part H (44g) was subjected to silica gel column chromatography (140-180 mesh), cyclohexane-acetone gradient elution (1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:4) Divided into six parts (H 1 -H 6 ). h 4 A portion (0.2 g) was subjected to medium pressure column chromatography, eluting with methanol-water (3.5:6.5) to obtain compound 1 (31 mg).

[0091] Compound 1 is light yellow...

Embodiment 3

[0094] Embodiment 3. Preparation of bis-oxyresveratrol (bis-oxyresveratrol, 7):

[0095] Dazi bought Gnetum montanum f.megalocarpum stem (10Kg), ground it and extracted it four times with 95% alcohol under reflux, distilled under reduced pressure to remove the solvent, obtained crude extract (870g) Soxhlet extraction, respectively with chloroform, Ethyl acetate, acetone, methanol elution. The ethyl acetate fraction (200g) was further subjected to silica gel column chromatography (140-180 mesh), chloroform-methanol gradient elution (30:1, 20:1, 15:1, 12:1, 10:1, 9:1 , 8:1, 6:1, 5:1, 4:1), divided into eight parts A-H. Part H (44g) was subjected to silica gel column chromatography (140-180 mesh), cyclohexane-acetone gradient elution (1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:4) Divided into six parts (H 1 -H 6 ). h 2 Part (0.23g) was subjected to medium pressure column chromatography, eluting with methanol-water (4:6) to obtain compound 7 (45mg).

[0096] Compound 7 is light yellow ...

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PUM

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Abstract

The invention relates to a veratrum album alcohol oligomer stilbene compounds and their preparing process, pharmaceutical compositions containing them, and their use as medicaments, especially as medicaments for treating chronic infectious arthritis, asthma and allergic inflammation.

Description

technical field [0001] The invention relates to resveratrol oligomeric stilbene compounds, their preparation method, their pharmaceutical composition and their application in the preparation of medicines for treating rheumatoid arthritis, asthma and allergic inflammation. Background technique [0002] Oligomer stilbene is a kind of rather novel compound with complex structure, most of their structural features are that resveratrol monomer or its analogues (such as 1, 7) coexist in the same way in different polymerization ways. in the plant. This kind of compound has high polarity, many types, difficult separation, and certain difficulty in structure identification. Since the 1990s, the research on this kind of compound has reached a climax at home and abroad. According to incomplete statistics, there are nearly 200 kinds of this kind of compound, usually polymerized with 2-4 monomers, and the highest degree of polymerization has reached 8 degrees. The pharmacological activ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/13C07C39/23C07C39/21C07D307/80A61K31/055A61K31/343A61P29/00A61P11/06A61P37/08
Inventor 林茂程桂芳李小妹姚春所李靖
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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