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Traditional Chinese medicine composite used for treating parkinsonism syndrome and preparation method thereof

A syndrome, Parkinson's technology, applied in the field of medicine, can solve problems such as records without prescription composition

Inactive Publication Date: 2009-10-07
NAN FANG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this prescription only has the name of the prescription, there is no record of the composition of the prescription, and there is no marketed drug for the treatment of PD

Method used

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  • Traditional Chinese medicine composite used for treating parkinsonism syndrome and preparation method thereof
  • Traditional Chinese medicine composite used for treating parkinsonism syndrome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] This example illustrates the preparation of the active substance.

[0021] [1] Take 1kg of licorice, 0.2kg of veratrum, crush them, and pass through a 20-mesh sieve;

[0022] [2] Reflux extraction with 3 times the amount of ethanol at 80°C for 3 to 5 hours, recover the ethanol to obtain 15 g of liquid extract.

Embodiment 2

[0024] This example illustrates the preparation of the active substance.

[0025] [1] Take 2kg of licorice, 0.4kg of veratrum, crush them, and pass through a 20-mesh sieve;

[0026] [2] Reflux extraction with 3 times the amount of ethanol at 80°C for 3 to 5 hours, recover the ethanol to obtain 31g of liquid extract.

[0027] [3] The liquid extract is dissolved in water and extracted with n-butanol;

[0028] [4] The extract was separated by chromatography to obtain 1.4g of crude flavonoids, 2.3g of saponins and 0.2g of alkaloids.

Embodiment 3

[0030] This example illustrates the preparation of the formulations.

[0031] The liquid extract in Example 1 was vacuum-dried, pulverized, added appropriate amount of starch and magnesium stearate, and pressed into tablets, 0.5 g per tablet, for the treatment of PD, 3 tablets each time, once a day.

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Abstract

The invention aims at proving a traditional Chinese medicine composite used for treating parkinsonism syndrome and a preparation method thereof. The traditional Chinese medicine composite is characterized by comprising the following raw materials of different proportions: veratrum or active materials extracted from the same and liquorice or active materials extracted from the same. The invention also provides a preparation method of the traditional Chinese medicine composite. The traditional Chinese medicine composite is used for treating the parkinsonism syndrome.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating Parkinson's syndrome and a preparation method thereof. Background technique [0002] Parkinson's disease (PD) is a slowly progressive neurodegenerative disease characterized by tremor, rigidity, and slow movement. The main pathological change is the appearance of Lewy bodies in the cytoplasm of nigrostriatal dopamine (DA) neurons. DA can cause neuronal degeneration or even necrosis. However, the pathogenesis of PD is still unclear. Surgical treatment of PD has been performed in humans for many years, such as cytoknife treatment, gamma knife treatment, tissue transplantation and stereotaxic brain surgery, etc., but drug treatment is still the first choice for the elderly. [0003] Dopaselazide is an important product in the anti-Parkinson's disease drug market. Other varieties include dopamine receptor agonists, such as bromocripti...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P25/16
Inventor 杨西晓侯连兵郭丹
Owner NAN FANG HOSPITAL
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