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Pulse type ultrasound microbubble treatment device and method for opening prostate barrier

An ultrasonic therapy, pulsed technology, used in ultrasonic therapy, therapy, drug devices, etc.

Inactive Publication Date: 2012-04-04
李陶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Harnessing this effect may enable non-invasive drug release or gene transfection

Method used

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  • Pulse type ultrasound microbubble treatment device and method for opening prostate barrier
  • Pulse type ultrasound microbubble treatment device and method for opening prostate barrier
  • Pulse type ultrasound microbubble treatment device and method for opening prostate barrier

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Experimental program
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Effect test

Embodiment Construction

[0025] Positioning diagnostic procedures, transrectal or transperineal ultrasound can clearly show the location of the prostate, providing the necessary conditions and feasibility for the implementation of ultrasound real-time monitoring and fixed-point emission.

[0026] Positioning therapy procedure, then, in the case of intravenous injection of said therapeutic dose of microbubbles, diagnostic ultrasound shows that at the peak of microbubble perfusion, therapeutic ultrasound with set parameters transrectally targeted irradiation of the prostate, using microbubble ultrasound sonoporation effect Non-invasive opening of the prostate barrier. The pulse duration is for the purpose of completely destroying the microbubbles, which is adjustable in 2-4 seconds; the intermittent time depends on the reperfusion time of the microbubbles, and can be adjusted in 4-8 seconds.

[0027] The treatment effect evaluation procedure, the opening degree of the prostate tissue barrier, can be tra...

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PUM

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Abstract

The invention relates to an ultrasonic treatment device and a method mediated by microbubbles for opening prostate barrier. The ultrasonic treatment device comprises an ultrasonic treatment unit and microbubbles, and the ultrasonic treatment device is characterized in that direct-current high voltage is used to generate high pulse, a high pulse switch functional tube is used as a control unit, the direct-current high voltage is supplied to an ultrasonic power oscillator by means of high pulse, and pulse signals are sent out. The treatment unit is capable of transmitting an intermittent pulse type ultrasonic energy form low in average sound intensity and high in peak sound pressure. In coordination with intravenous microbubble injection, microbubble ultrasonic cavitation in blood circulation is induced under pulse type ultrasonic transmission, the prostate barrier is opened noninvasively under microbubble sonoporation, drug penetration into prostate tissue cells is promoted, a novel way of noninvasive prostate drug treatment is developed, drug effect is given to fullest play, drug application time is shortened, and treatment cost is saved.

Description

technical field [0001] The invention relates to an ultrasonic treatment device combined with microbubbles, which uses an open prostate barrier to promote drug penetration and gene transfection of the prostate, and belongs to the technical field of non-invasive ultrasonic treatment. technical background [0002] At present, the incidence of prostate disease is gradually increasing, and prostate disease has become a major worldwide disease for men, such as prostatitis, benign prostatic hyperplasia, and prostate cancer, which seriously threaten human health. [0003] Due to the special anatomical structure of the outer fibrous capsule of the prostate, the acinar epithelial lipid membrane (extended to wrap to the gland lobules), the blood-prostate barrier, and the distribution of blood vessels outside the capsule, the use of prostate medication has always troubled clinicians and is an urgent problem to be solved . Such as chronic prostatitis, because of the fibrosis of the fibr...

Claims

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Application Information

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IPC IPC(8): A61N7/00A61M37/00
Inventor 李陶刘政
Owner 李陶
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