68results about "Vibration crystallization" patented technology

The invention provides an ultrasonic-assisted gamma-aminobutyric acid crystallization particle size regulation and control method, which comprises the following steps: removing impurities and decolorizing gamma-aminobutyric acid-containing feed liquid, heating, stirring and concentrating to a nearly saturated state, then carrying out ultrasonic-assisted crystallization, cooling, aging and suction filtration to obtain coarse crystals, and finally washing and drying to obtain target crystals. According to the method, a synergistic process of raw material liquid pretreatment, evaporation concentration-ultrasonic-cooling coupling crystallization, aging and post-treatment is adopted, an ultrasonic cavitation effect is utilized to reduce a nucleation barrier, and a supersaturation degree precise control and gradient cooling strategy is combined, so that grain size refinement, obvious narrowing of distribution and effective inhibition of agglomeration of crystals are realized; the median particle size of the crystal can be controlled to be smaller than or equal to 200 microns, the particle size distribution span is smaller than or equal to 1.5, the agglomeration phenomenon is remarkably inhibited, the crystal form is kept stable, the crystal habit is complete and smooth, the crystal product quality and the process efficiency are remarkably improved, and the method has important industrial application value.

The present invention relates to the technical field of rare earth, and in particular to a device and method for preparing a nano rare earth oxide by means of cooperation of ultrasonic waves and microwaves. By using the device, a nano rare earth oxide is prepared by means of processes such as stirring, reacting, filtering, washing, drying, and burning. The "internal heating" of microwaves and "cavitation" of ultrasonic waves can effectively accelerate the reaction, shorten the reaction time, and speed up the reaction rate, so as to obtain nanomaterials with no agglomeration and uniform particle size; the heat effect of the ultrasonic waves provides enough energy for ions waiting for nucleation in a solution, so as to promote formation of crystal nucleuses; and the chemical effect of ultrasonic waves can effectively promote primary nucleation and secondary nucleation of crystals, and provides energy for ions which cannot be nucleated. Stirring is implemented by means of the "cavitation" and mechanical effect of ultrasonic waves, and the strength of stirring is far higher than that of common mechanical stirring, effectively hindering grain growth, and thus obtaining superfine powder having a small particle size, good dispersity and complete crystallization.

The invention provides a production device and process for increasing the content of magnesium citrate crystals. The problems that in the prior art, the impurity co-crystallization rate is high, and crystal forms are difficult to control are solved. The device comprises a gradient temperature control multi-stage crystallization device and a crystal form directional regulation and self-adaptive separation system. The gradient temperature control multi-stage crystallization device is composed of a main crystallizer, a gradient temperature control system, an ultrasonic-assisted system and a liquid phase partition circulating system, and the crystallization environment is accurately controlled through the temperature gradients of five independent temperature zones. The crystal form directional regulation and self-adaptive separation system is composed of a seed crystal dynamic inoculation device, an electric field auxiliary directional crystallization system, a real-time crystal morphology analysis system and a self-adaptive separation system, and the crystal morphology and particle size distribution can be accurately controlled. According to the process disclosed by the invention, the main content of magnesium citrate is increased to 98.8 + / -0.3%, heavy metal impurities and organic impurities are respectively reduced by 70% and 75%, the crystal form consistency is increased to 96 + / -2%, the production period is shortened by 33%, and the process has remarkable economic benefits and social benefits.

Described are liquid compositions that contain a desired (e.g., extracted) plant material such as cannabinoid, terpene, terpenoid, or the like, contained, e.g., dissolved, suspended, or emulsified, in the liquid, which contains surfactant; methods of preparing these types of liquid compositions; and methods of processing this type of liquid composition to collect, isolate, concentrate, or purify a desired target material contained in the liquid composition.

The invention discloses an ultrasonic crystallization device for preparing high-purity ethyl maltol and a process thereof, relating to the technical field of ethyl maltol preparation. The device comprises an installation stand and a reactor body, wherein a rotating plate is rotatably installed on the top of the reactor body, and further comprises a grinding component, a stirring component and an ultrasonic oscillation component. The device can refine powder in a grinding area to avoid agglomeration. On the other hand, when a subsequent hydraulic rod moves downward, it can drive a sealing ring plug to move downward, thereby allowing a portion of air in an inner grinding cylinder to pass into an annular cavity through a one-way air outlet valve, and finally to be diverted through multiple oblique branches and blown into a drop hole on the rotating plate, thereby promoting the falling of the powder. At the same time, another portion of air in the inner grinding cylinder is aerated into the reactor body through a bottom through-pipe and the one-way air outlet valve, thereby achieving the effects of assisting material dissolution and promoting subsequent crystallization.

A process for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C,D,S1,S2), comprising the steps of preparing (I) a supersaturated solution from said compounds, homogenizing (II) said supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a determined period, exposing said tubes (54) to a pulsed and polarized laser beam before and / or during exposure, monitoring in situ the nucleation and then the growth of co-crystals inside said tubes (54), and filtering the exposed solutions to recover co-crystals larger than a predetermined minimum size.This process is implemented to carry out co-crystallization from at least one active substance (D) and one co-former (C) in at least one first solvent (S1) and one second solvent (S2), and it further comprises two preliminary steps: establishing a phase diagram from the respective physicochemical characteristics of said active substance (D), said co-former (C), said first solvent (S1) and said second solvent (S2), and then determining, from said phase diagram thus established, concentration, temperature and exposure conditions providing a stable phase for the production of co-crystals. See Figure 4.

The invention relates to a continuous crystallization system and method of lithium hexafluorophosphate, and belongs to the technical field of lithium ion battery electrolyte production. Aiming at the characteristics and requirements of a lithium hexafluorophosphate cooling crystallization process, the invention provides a continuous crystallization system of lithium hexafluorophosphate, which separates cooling nucleation from cooling crystallization. An ultrasonic generating device is introduced into the cooling nucleation module, lithium hexafluorophosphate is stimulated and induced by ultrasonic waves to nucleate, limitation of a metastable region is reduced, the nucleation rate is increased, crystal nuclei are controlled to be within a small particle size distribution range, meanwhile, introduction of impurities in the nucleation process is reduced, and the product purity is guaranteed. And the lithium hexafluorophosphate solution to be crystallized can continuously and uninterruptedly enter the cooling nucleation module, the cooling crystallization module and the separation circulation module in sequence, so that the continuous crystallization of the lithium hexafluorophosphate is realized, the crystallization time is greatly shortened, and the crystallization efficiency is improved.

Method for producing electronic grade nickel sulfate from nickel powder, crystallization apparatus, and control thereof The present invention provides a method for producing nickel sulfate, and nickel sulfate produced thereby. The process includes acid leaching, copper removal, acid adjustment, concentration, cooling crystallization, drying and sieving, and secondary leaching. Oxidation In the calcination furnace, the temperature is 400 to 700°C, and 1 kg of compressed air is used for each kilogram of nickel powder. ~5m 3 The reaction time is 1.0 to 2.5 hours, and the temperature during acid immersion is controlled to 45 to 70°C. Then, add dilute sulfuric acid to control the pH to 0.5-1.5 and react for 1-3 hours. The copper removal is to replace the copper with nickel powder, and the acid conditioning is to use nickel hydroxide or The pH is adjusted to 2.5-4.5 using nickel carbonate, and the filtrate is concentrated by The cooling crystallization method is to obtain nickel sulfate crystals and return the mother liquor to the concentrate. Drying and sieving is to add the undersieved material to the crystallizer as seed crystals, and secondary leaching is to Dilute sulfuric acid is added to the leaching slag, and it is reacted with nickel sulfate or hydrogen peroxide until nickel is less than 0.1%. If the first stage is full, the second leaching is continued. The crystallizer is a crystallizer that is connected in series with a second-stage crystallizer and a third-stage crystallizer. A crystallization frame, an oscillator provided under the crystallization frame, and an oscillator provided at the exit end of the crystallization frame. The crystallization frame is a rectangular parallelepiped. The bottom of the ribs are evenly spaced, with a cross section of a circular arc. The distance between two adjacent ribs is S is 1 / 25 to 1 / 15 of the width of the crystallization frame, and either the width b or the height h of the rib The width of the crystallization frame is 1 / 100 to 1 / 150 of the width of the crystallization frame. It does not add any new impurity ions, and does not add any oxidizing agent. The nickel sulfate crystal particles produced are uniform and are free of the static generation. This avoids caking of very large particles, irregularly shaped particles and crystals.

The invention discloses a crystallization device, a brine lithium extraction system and a process thereof, and relates to the technical field of lithium ion recovery, the crystallization device comprises a crystallizer body, a stirring mechanism and a first vibration element, the crystallizer body is internally used for accommodating slurry, a feeding part on the crystallizer body is used for introducing a sodium carbonate solution and brine, and a discharging part on the crystallizer body is used for discharging lithium carbonate crystal slurry; the stirring mechanism is used for stirring slurry in the crystallizer body; the first vibration element is arranged on the side wall of the crystallizer body and can apply mechanical vibration to the crystallizer body, on one hand, strong fluid disturbance can be generated in mixed feed liquid of brine and a sodium carbonate solution, and mixing and mass transfer between the brine and the sodium carbonate solution are enhanced; on the other hand, the concentration gradient between solid-liquid phases and the concentration gradient inside feed liquid can be destroyed, local supersaturation areas are avoided, the uniformity of crystal nucleation growth is improved, on the other hand, the physical adsorption force and chemical bonding between crystal nuclei and the inner wall of the crystallizer body can be destroyed, and the nucleation growth efficiency of crystals is improved.

Band-pass filters for guiding or controlling crystal polymorphism in oil are provided. Band-pass filters convert a passive energy source to a spectral energy pattern tuned to be resonant with different types of molecular oscillations pertinent to oil. Tuned energy patterns convert problematic insoluble crystals to more thermodynamically stable and soluble crystals. Methods include use of the band-pass filter in crude oil recovery and design of band-pass filter parameters for optimal use on a particular oil recovery facility. Band-pass filters also lower the interfacial tension of oil when present with water, which are also provided, as are methods for enhanced recovery of oil from depleted oil fields.

The invention relates to a method for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C, D, S1, S2), the method comprising steps of preparing (I) a supersaturated solution from the compounds, homogenizing (II) the supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a predetermined period of time, exposing the tubes (54) to a polarized pulsed laser beam before and / or during exposure, followed in situ by nucleation and then growing cocrystals inside the tubes (54), and filtering the exposed solutions in order to recover cocrystals having a size greater than a predetermined minimum size. This method is carried out in order to obtain cocrystallization from at least one active substance (D) and a coformer (C) in at least a first solvent (S1) and a second solvent (S2).

A method of manufacturing a particulate transition metal carbonate material is described. The method includes mixing a transition metal precursor salt with a second salt in a liquid vehicle. A precipitation reaction is then performed to form a slurry of the particulate transition metal carbonate material in the liquid vehicle. The particulate transition metal carbonate material may find use as seeds in a subsequent precipitation reaction. Methods of manufacturing a particulate precursor materials are also described, including performing a precipitation reaction between one or more transition metal sources in the presence of seed particles in a reaction mixture within a precipitation reaction vessel, to form the particulate precursor material by precipitation onto the surface of the seed particles.

This invention discloses an ultrasonic-cold finger coupled plate melt crystallizer and a continuous purification process. The crystallizer body includes multiple heat exchange plates, each with a built-in serpentine refrigerant channel; multiple ultrasonic vibrating plates are sequentially arranged around the shell of the plate melt crystallizer to provide an ultrasonic field covering the entire crystallizer body; at least one cold finger assembly is located on top of the plate melt crystallizer and connected to the upper cover plate of the crystallizer body via a detachable flange. The cold finger assembly includes an inlet manifold, an outlet manifold, a cold finger body, and an ultrasonic probe. The inlet and outlet manifolds are arranged parallel to each other above the crystallizer body along a second direction. The bottom of each cold finger body is located within the crystallizer body, and its top two ends are connected to the inlet and outlet manifolds, respectively. The ultrasonic probe extends along a third direction and is inserted into the interior of the cold finger body. Using the melt crystallizer and process of this invention enables higher crystallization efficiency and greater product yield.

The invention discloses an experimental device for a drug crystallization process. The experimental device comprises a reactor, a lifting probe assembly, a crystallization guide assembly and a control system. The reactor comprises a reaction kettle and a heating base which are in heat conduction connection; the lifting probe assembly is mounted on the reaction kettle and can extend below the liquid level to shoot crystal images; the crystallization guide assembly comprises a rotary driving mechanism, a shaft tube, a first ultrasonic transducer, a second ultrasonic transducer, a focused light beam reflection measuring instrument, a turbidity sensor and a stirring piece; wherein the frequency of the first ultrasonic transducer is lower than that of the second ultrasonic transducer, and the first ultrasonic transducer and the second ultrasonic transducer are used for inducing nucleation and fine grain elimination; the focused beam reflection measuring instrument monitors the number and granularity of crystals; the heating base, the lifting probe assembly, the rotary driving mechanism, the first ultrasonic transducer, the second ultrasonic transducer, the focused light beam reflection measuring instrument and the turbidity sensor are all electrically connected with the control system, so that monitoring and control of the experiment process are realized, the crystallization efficiency is effectively improved, and high-quality crystals are obtained.

The invention relates to the technical field of crystallization, in particular to a sodium bromide production device and method. The sodium bromide production device comprises a base, and the upper end face of the base is fixedly connected with a shell; the crystallization mechanism comprises a crystallization box fixedly connected to the upper half part in the shell, a cross-shaped partition plate is fixedly connected to the interior of the crystallization box, and the interior of the crystallization box is divided into a plurality of crystallization areas with the same volume by the cross-shaped partition plate; a vibration guide assembly, two resonance assemblies and a liquid level detector are arranged in each crystallization area, and the upper end face of the crystallization box is connected with a turning cover through a hinge; through a cross-shaped partition plate, a vibration guide assembly and a resonance assembly in the crystallization mechanism, sodium bromide to be crystallized in the crystallization box can be subjected to partition crystallization and uniform crystallization, and the vibration guide assembly can transmit vibration waves to a detector to master the crystallization condition, so that the crystallization uniformity and quality of the sodium bromide can be improved, and the crystallization efficiency is improved. And the uniformity and efficiency of the crystallization process are effectively improved.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The application discloses a kind of ultrasonic reinforced C8 aromatic hydrocarbon crystallization separation method and system, belong to C8 aromatic hydrocarbon separation technical field.The system of the present application mainly includes primary crystallizer, centrifugal filter, melting tank, ultrasonic generator and the like device.According to the different separation requirements of raw material, different process flow and process system are used in the present application, two-stage filtration process and the combination process of fine filtration are first proposed in C8 aromatic hydrocarbon separation, and the separation of ethylbenzene and xylene can be realized through primary crystallization and filtration, with high separation purity;At the same time, the present application can select coarse separation or fine separation according to the purity requirement of process product, and the raw material has wide adaptability and flexible process.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The invention relates to a method for purification of feed liquid (F), the feed liquid (F) containing minerals or chemicals or both, the method having the followings steps of: - feeding feed liquid (F) into a tank (40) and pressurizing the feed liquid (F) to a high pressure using a piston (90) extending partially outside the tank (40), the piston (90) being attached to an actuator (32) located at least outside the tank (40) for pushing and pulling the piston (90), - cooling the feed liquid (F) near freezing point, - expanding the feed liquid (F) adiabatically to essentially normal pressure forming a mixture of ice and liquid brine (B), - removing and collecting the liquid brine (B), - feeding product liquid (P) forming a second mixture of ice and product liquid (P), - pressurizing the second mixture to high pressure, - using the second mixture to cool feed liquid (F) under high pressure expanding the second mixture adiabatically to essentially normal pressure, - removing the second mixture from the tank (40) as the product liquid (P). The invention relates also to a system for purification of feed liquid (F).

The invention discloses an ultrasonic crystallization device for preparing high-purity ethyl maltol and a process thereof, and relates to the technical field of ethyl maltol preparation, the ultrasonic crystallization device comprises a mounting vertical frame and a reaction kettle body, the top end of the reaction kettle body is rotatably provided with a rotating plate, and the ultrasonic crystallization device further comprises a grinding assembly, a stirring assembly and an ultrasonic oscillation assembly; according to the powder grinding device, powder can be refined in the grinding area, and the caking condition is avoided; on the other hand, when a follow-up hydraulic rod moves downwards, a sealing ring plug can be driven to move downwards, so that a part of air in the grinding inner cylinder is introduced into a ring cavity through a one-way air outlet valve I, and finally, the air is shunted through a plurality of inclined branch ports and is blown into a blanking hole in a rotating plate, so that the powder is promoted to fall off; meanwhile, the other part of air in the grinding inner cylinder is aerated into the reaction kettle body through a bottom through pipe and a one-way air outlet valve II, so that the effects of assisting material dissolution and promoting subsequent crystallization are achieved.

The invention discloses an extraction and purification method, purification equipment and system for anodic oxidation chemical polishing waste liquid phosphoric acid, relates to the technical field of waste liquid recovery and phosphoric acid purification, and solves the technical problems that the existing anodic oxidation chemical polishing waste liquid phosphoric acid extraction effect is poor, and the purity needs to be improved. S2, an impurity removal agent is added into the chemical polishing waste acid solution obtained after preliminary filtration and impurity removal in the step S1, solid-liquid separation is conducted after mixing, and clear liquid and sediment are obtained; s3, carrying out negative-pressure low-temperature evaporation on the clear liquid obtained in S2 to obtain concentrated liquid; s4, phosphoric acid seed crystals are added into the concentrated solution obtained in S3 for crystal growth purification, and purified phosphoric acid is obtained.The purification system comprises a filtering device, a precipitation tank, a storage tank, Mcllaval low-temperature evaporation equipment and purification equipment which are arranged in sequence, and the technical effects that the purity of obtained phosphoric acid is high, and the electronic grade E1 is achieved are achieved.

A method of manufacturing a particulate precursor material, comprising providing a suspension of seed particles in a liquid vehicle. A precipitation reaction involving one or more transition metal sou

The invention relates to the technical field of devitrification cooling, and discloses an ultrasonic-assisted benzohydroxamic acid rapid devitrification cooling device which comprises a cooling cover, a condensation pipe is mounted at the position, located at the lower edge of a mounting groove, in the cooling cover, first through holes are formed in the middle positions of the two sides of the inner wall of the cooling cover, and second through holes are formed in one sides of two baffles. During centralized cooling, air flow cooled by the condensation pipe can only be exhausted from the exhaust groove for centralized cooling, and when the number of high-temperature operation areas on the ultrasonic-assisted equipment is large, the air flow can only be exhausted through the second butt joint covers, hoses and the like, so that the high-temperature operation areas of the ultrasonic-assisted equipment are reduced, and the cooling efficiency is improved. And the electric push rod is started to push the baffle to communicate the first through hole with the first butt joint cover through the second through hole, low-temperature airflow of the cooling cover passes through the third butt joint cover, part of the low-temperature airflow is blown into other areas of the equipment, a devitrification cooling device does not need to be additionally installed, and the cooling and temperature control cost of the ultrasonic-assisted equipment is reduced.

A method for purification of feed liquid containing minerals or chemicals or both, having steps offeeding feed liquid into a tank and pressurizing the feed liquid to a high pressure using a piston extending partially outside the tank, the piston being attached to an actuator located at least outside the tank for pushing and pulling the piston,cooling the feed liquid near freezing point;expanding the feed liquid adiabatically to essentially normal pressure forming a mixture of ice and liquid brine;removing and collecting the liquid brine;feeding product liquid forming a second mixture of ice and product liquid;pressurizing the second mixture to high pressure;using the second mixture to cool feed liquid under high pressure expanding the second mixture adiabatically to essentially normal pressure; andremoving the second mixture from the tank as the product liquid.

The present disclosure relates to a method for crystallization of an active pharmaceutical ingredient (API), where the crystallization and crystal growth are controlled. According to the method, an aqueous solution comprising a solid amorphous nano-sized API and one or more polymers and / or copolymers are contacted to form a suspension comprising the nano-sized API in a crystalline form.

The present invention relates to a three-phase methodology to obtain a highly concentrated, purified chemical component from plant material in an industrial setting. The three phases of the methodology of the present invention include Phase 1 : Preparing and solubilization, Phase 2: Separation and Salting and Phase 3: crystallization. The methodology results in dried composition purified from a plant material having at least 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% of the chemical component by weight.

A method of manufacturing a particulate transition metal carbonate material is described. The method includes mixing a transition metal precursor salt with a second salt in a liquid vehicle. A precipitation reaction is then performed to form a slurry of the particulate transition metal carbonate material in the liquid vehicle. The particulate transition metal carbonate material may find use as seeds in a subsequent precipitation reaction. Methods of manufacturing a particulate precursor materials are also described, including performing a precipitation reaction between one or more transition metal sources in the presence of seed particles in a reaction mixture within a precipitation reaction vessel, to form the particulate precursor material by precipitation onto the surface of the seed particles.

A method of manufacturing a particulate precursor material, comprising providing a suspension of seed particles in a liquid vehicle. A precipitation reaction involving one or more transition metal sou

A hydrate of a VEGFR inhibitor, a crystal form thereof and a preparation method therefor are provided. The VEGFR inhibitor is 6-(6,7-dimethoxyquinazolin-4-yl-oxy)-N,2-dimethylbenzofuran-3-carboxamide, and the hydrate and the crystal form thereof have good physicochemical properties, and have good flowability, solubility, stability and bioavailability, and alleviated hygroscopicity. In addition, the preparation method is simple, has good repeatability, achieves high yield, and is easy to perform and environment-friendly, and the method requires only a small amount of solvents and facilitates recycling use, thus effectively reducing the cost on reagents, and enabling easy implementation of large-scale mass production.

The present invention relates to a three-phase methodology to obtain a highly concentrated, purified chemical component from plant material in an industrial setting. The three phases of the methodology of the present invention include Phase 1 : Preparing and solubilization, Phase 2: Separation and Salting and Phase 3: crystallization. The methodology results in dried composition purified from a plant material having at least 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% of the chemical component by weight.