55results about "Vibration crystallization" patented technology

The invention provides an ultrasonic-assisted gamma-aminobutyric acid crystallization particle size regulation and control method, which comprises the following steps: removing impurities and decolorizing gamma-aminobutyric acid-containing feed liquid, heating, stirring and concentrating to a nearly saturated state, then carrying out ultrasonic-assisted crystallization, cooling, aging and suction filtration to obtain coarse crystals, and finally washing and drying to obtain target crystals. According to the method, a synergistic process of raw material liquid pretreatment, evaporation concentration-ultrasonic-cooling coupling crystallization, aging and post-treatment is adopted, an ultrasonic cavitation effect is utilized to reduce a nucleation barrier, and a supersaturation degree precise control and gradient cooling strategy is combined, so that grain size refinement, obvious narrowing of distribution and effective inhibition of agglomeration of crystals are realized; the median particle size of the crystal can be controlled to be smaller than or equal to 200 microns, the particle size distribution span is smaller than or equal to 1.5, the agglomeration phenomenon is remarkably inhibited, the crystal form is kept stable, the crystal habit is complete and smooth, the crystal product quality and the process efficiency are remarkably improved, and the method has important industrial application value.

The invention provides a production device and process for increasing the content of magnesium citrate crystals. The problems that in the prior art, the impurity co-crystallization rate is high, and crystal forms are difficult to control are solved. The device comprises a gradient temperature control multi-stage crystallization device and a crystal form directional regulation and self-adaptive separation system. The gradient temperature control multi-stage crystallization device is composed of a main crystallizer, a gradient temperature control system, an ultrasonic-assisted system and a liquid phase partition circulating system, and the crystallization environment is accurately controlled through the temperature gradients of five independent temperature zones. The crystal form directional regulation and self-adaptive separation system is composed of a seed crystal dynamic inoculation device, an electric field auxiliary directional crystallization system, a real-time crystal morphology analysis system and a self-adaptive separation system, and the crystal morphology and particle size distribution can be accurately controlled. According to the process disclosed by the invention, the main content of magnesium citrate is increased to 98.8 + / -0.3%, heavy metal impurities and organic impurities are respectively reduced by 70% and 75%, the crystal form consistency is increased to 96 + / -2%, the production period is shortened by 33%, and the process has remarkable economic benefits and social benefits.

Described are liquid compositions that contain a desired (e.g., extracted) plant material such as cannabinoid, terpene, terpenoid, or the like, contained, e.g., dissolved, suspended, or emulsified, in the liquid, which contains surfactant; methods of preparing these types of liquid compositions; and methods of processing this type of liquid composition to collect, isolate, concentrate, or purify a desired target material contained in the liquid composition.

The invention discloses an ultrasonic crystallization device for preparing high-purity ethyl maltol and a process thereof, relating to the technical field of ethyl maltol preparation. The device comprises an installation stand and a reactor body, wherein a rotating plate is rotatably installed on the top of the reactor body, and further comprises a grinding component, a stirring component and an ultrasonic oscillation component. The device can refine powder in a grinding area to avoid agglomeration. On the other hand, when a subsequent hydraulic rod moves downward, it can drive a sealing ring plug to move downward, thereby allowing a portion of air in an inner grinding cylinder to pass into an annular cavity through a one-way air outlet valve, and finally to be diverted through multiple oblique branches and blown into a drop hole on the rotating plate, thereby promoting the falling of the powder. At the same time, another portion of air in the inner grinding cylinder is aerated into the reactor body through a bottom through-pipe and the one-way air outlet valve, thereby achieving the effects of assisting material dissolution and promoting subsequent crystallization.

A process for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C,D,S1,S2), comprising the steps of preparing (I) a supersaturated solution from said compounds, homogenizing (II) said supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a determined period, exposing said tubes (54) to a pulsed and polarized laser beam before and / or during exposure, monitoring in situ the nucleation and then the growth of co-crystals inside said tubes (54), and filtering the exposed solutions to recover co-crystals larger than a predetermined minimum size.This process is implemented to carry out co-crystallization from at least one active substance (D) and one co-former (C) in at least one first solvent (S1) and one second solvent (S2), and it further comprises two preliminary steps: establishing a phase diagram from the respective physicochemical characteristics of said active substance (D), said co-former (C), said first solvent (S1) and said second solvent (S2), and then determining, from said phase diagram thus established, concentration, temperature and exposure conditions providing a stable phase for the production of co-crystals. See Figure 4.

Method for producing electronic grade nickel sulfate from nickel powder, crystallization apparatus, and control thereof The present invention provides a method for producing nickel sulfate, and nickel sulfate produced thereby. The process includes acid leaching, copper removal, acid adjustment, concentration, cooling crystallization, drying and sieving, and secondary leaching. Oxidation In the calcination furnace, the temperature is 400 to 700°C, and 1 kg of compressed air is used for each kilogram of nickel powder. ~5m 3 The reaction time is 1.0 to 2.5 hours, and the temperature during acid immersion is controlled to 45 to 70°C. Then, add dilute sulfuric acid to control the pH to 0.5-1.5 and react for 1-3 hours. The copper removal is to replace the copper with nickel powder, and the acid conditioning is to use nickel hydroxide or The pH is adjusted to 2.5-4.5 using nickel carbonate, and the filtrate is concentrated by The cooling crystallization method is to obtain nickel sulfate crystals and return the mother liquor to the concentrate. Drying and sieving is to add the undersieved material to the crystallizer as seed crystals, and secondary leaching is to Dilute sulfuric acid is added to the leaching slag, and it is reacted with nickel sulfate or hydrogen peroxide until nickel is less than 0.1%. If the first stage is full, the second leaching is continued. The crystallizer is a crystallizer that is connected in series with a second-stage crystallizer and a third-stage crystallizer. A crystallization frame, an oscillator provided under the crystallization frame, and an oscillator provided at the exit end of the crystallization frame. The crystallization frame is a rectangular parallelepiped. The bottom of the ribs are evenly spaced, with a cross section of a circular arc. The distance between two adjacent ribs is S is 1 / 25 to 1 / 15 of the width of the crystallization frame, and either the width b or the height h of the rib The width of the crystallization frame is 1 / 100 to 1 / 150 of the width of the crystallization frame. It does not add any new impurity ions, and does not add any oxidizing agent. The nickel sulfate crystal particles produced are uniform and are free of the static generation. This avoids caking of very large particles, irregularly shaped particles and crystals.

The invention discloses a crystallization device, a brine lithium extraction system and a process thereof, and relates to the technical field of lithium ion recovery, the crystallization device comprises a crystallizer body, a stirring mechanism and a first vibration element, the crystallizer body is internally used for accommodating slurry, a feeding part on the crystallizer body is used for introducing a sodium carbonate solution and brine, and a discharging part on the crystallizer body is used for discharging lithium carbonate crystal slurry; the stirring mechanism is used for stirring slurry in the crystallizer body; the first vibration element is arranged on the side wall of the crystallizer body and can apply mechanical vibration to the crystallizer body, on one hand, strong fluid disturbance can be generated in mixed feed liquid of brine and a sodium carbonate solution, and mixing and mass transfer between the brine and the sodium carbonate solution are enhanced; on the other hand, the concentration gradient between solid-liquid phases and the concentration gradient inside feed liquid can be destroyed, local supersaturation areas are avoided, the uniformity of crystal nucleation growth is improved, on the other hand, the physical adsorption force and chemical bonding between crystal nuclei and the inner wall of the crystallizer body can be destroyed, and the nucleation growth efficiency of crystals is improved.

The invention relates to a method for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C, D, S1, S2), the method comprising steps of preparing (I) a supersaturated solution from the compounds, homogenizing (II) the supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a predetermined period of time, exposing the tubes (54) to a polarized pulsed laser beam before and / or during exposure, followed in situ by nucleation and then growing cocrystals inside the tubes (54), and filtering the exposed solutions in order to recover cocrystals having a size greater than a predetermined minimum size. This method is carried out in order to obtain cocrystallization from at least one active substance (D) and a coformer (C) in at least a first solvent (S1) and a second solvent (S2).

A method of manufacturing a particulate transition metal carbonate material is described. The method includes mixing a transition metal precursor salt with a second salt in a liquid vehicle. A precipitation reaction is then performed to form a slurry of the particulate transition metal carbonate material in the liquid vehicle. The particulate transition metal carbonate material may find use as seeds in a subsequent precipitation reaction. Methods of manufacturing a particulate precursor materials are also described, including performing a precipitation reaction between one or more transition metal sources in the presence of seed particles in a reaction mixture within a precipitation reaction vessel, to form the particulate precursor material by precipitation onto the surface of the seed particles.

This invention discloses an ultrasonic-cold finger coupled plate melt crystallizer and a continuous purification process. The crystallizer body includes multiple heat exchange plates, each with a built-in serpentine refrigerant channel; multiple ultrasonic vibrating plates are sequentially arranged around the shell of the plate melt crystallizer to provide an ultrasonic field covering the entire crystallizer body; at least one cold finger assembly is located on top of the plate melt crystallizer and connected to the upper cover plate of the crystallizer body via a detachable flange. The cold finger assembly includes an inlet manifold, an outlet manifold, a cold finger body, and an ultrasonic probe. The inlet and outlet manifolds are arranged parallel to each other above the crystallizer body along a second direction. The bottom of each cold finger body is located within the crystallizer body, and its top two ends are connected to the inlet and outlet manifolds, respectively. The ultrasonic probe extends along a third direction and is inserted into the interior of the cold finger body. Using the melt crystallizer and process of this invention enables higher crystallization efficiency and greater product yield.

The invention discloses an experimental device for a drug crystallization process. The experimental device comprises a reactor, a lifting probe assembly, a crystallization guide assembly and a control system. The reactor comprises a reaction kettle and a heating base which are in heat conduction connection; the lifting probe assembly is mounted on the reaction kettle and can extend below the liquid level to shoot crystal images; the crystallization guide assembly comprises a rotary driving mechanism, a shaft tube, a first ultrasonic transducer, a second ultrasonic transducer, a focused light beam reflection measuring instrument, a turbidity sensor and a stirring piece; wherein the frequency of the first ultrasonic transducer is lower than that of the second ultrasonic transducer, and the first ultrasonic transducer and the second ultrasonic transducer are used for inducing nucleation and fine grain elimination; the focused beam reflection measuring instrument monitors the number and granularity of crystals; the heating base, the lifting probe assembly, the rotary driving mechanism, the first ultrasonic transducer, the second ultrasonic transducer, the focused light beam reflection measuring instrument and the turbidity sensor are all electrically connected with the control system, so that monitoring and control of the experiment process are realized, the crystallization efficiency is effectively improved, and high-quality crystals are obtained.

The invention relates to the technical field of crystallization, in particular to a sodium bromide production device and method. The sodium bromide production device comprises a base, and the upper end face of the base is fixedly connected with a shell; the crystallization mechanism comprises a crystallization box fixedly connected to the upper half part in the shell, a cross-shaped partition plate is fixedly connected to the interior of the crystallization box, and the interior of the crystallization box is divided into a plurality of crystallization areas with the same volume by the cross-shaped partition plate; a vibration guide assembly, two resonance assemblies and a liquid level detector are arranged in each crystallization area, and the upper end face of the crystallization box is connected with a turning cover through a hinge; through a cross-shaped partition plate, a vibration guide assembly and a resonance assembly in the crystallization mechanism, sodium bromide to be crystallized in the crystallization box can be subjected to partition crystallization and uniform crystallization, and the vibration guide assembly can transmit vibration waves to a detector to master the crystallization condition, so that the crystallization uniformity and quality of the sodium bromide can be improved, and the crystallization efficiency is improved. And the uniformity and efficiency of the crystallization process are effectively improved.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The application discloses a kind of ultrasonic reinforced C8 aromatic hydrocarbon crystallization separation method and system, belong to C8 aromatic hydrocarbon separation technical field.The system of the present application mainly includes primary crystallizer, centrifugal filter, melting tank, ultrasonic generator and the like device.According to the different separation requirements of raw material, different process flow and process system are used in the present application, two-stage filtration process and the combination process of fine filtration are first proposed in C8 aromatic hydrocarbon separation, and the separation of ethylbenzene and xylene can be realized through primary crystallization and filtration, with high separation purity;At the same time, the present application can select coarse separation or fine separation according to the purity requirement of process product, and the raw material has wide adaptability and flexible process.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The invention discloses an extraction and purification method, purification equipment and system for anodic oxidation chemical polishing waste liquid phosphoric acid, relates to the technical field of waste liquid recovery and phosphoric acid purification, and solves the technical problems that the existing anodic oxidation chemical polishing waste liquid phosphoric acid extraction effect is poor, and the purity needs to be improved. S2, an impurity removal agent is added into the chemical polishing waste acid solution obtained after preliminary filtration and impurity removal in the step S1, solid-liquid separation is conducted after mixing, and clear liquid and sediment are obtained; s3, carrying out negative-pressure low-temperature evaporation on the clear liquid obtained in S2 to obtain concentrated liquid; s4, phosphoric acid seed crystals are added into the concentrated solution obtained in S3 for crystal growth purification, and purified phosphoric acid is obtained.The purification system comprises a filtering device, a precipitation tank, a storage tank, Mcllaval low-temperature evaporation equipment and purification equipment which are arranged in sequence, and the technical effects that the purity of obtained phosphoric acid is high, and the electronic grade E1 is achieved are achieved.

A method of manufacturing a particulate precursor material, comprising providing a suspension of seed particles in a liquid vehicle. A precipitation reaction involving one or more transition metal sou

The invention relates to the technical field of devitrification cooling, and discloses an ultrasonic-assisted benzohydroxamic acid rapid devitrification cooling device which comprises a cooling cover, a condensation pipe is mounted at the position, located at the lower edge of a mounting groove, in the cooling cover, first through holes are formed in the middle positions of the two sides of the inner wall of the cooling cover, and second through holes are formed in one sides of two baffles. During centralized cooling, air flow cooled by the condensation pipe can only be exhausted from the exhaust groove for centralized cooling, and when the number of high-temperature operation areas on the ultrasonic-assisted equipment is large, the air flow can only be exhausted through the second butt joint covers, hoses and the like, so that the high-temperature operation areas of the ultrasonic-assisted equipment are reduced, and the cooling efficiency is improved. And the electric push rod is started to push the baffle to communicate the first through hole with the first butt joint cover through the second through hole, low-temperature airflow of the cooling cover passes through the third butt joint cover, part of the low-temperature airflow is blown into other areas of the equipment, a devitrification cooling device does not need to be additionally installed, and the cooling and temperature control cost of the ultrasonic-assisted equipment is reduced.

A method for purification of feed liquid containing minerals or chemicals or both, having steps offeeding feed liquid into a tank and pressurizing the feed liquid to a high pressure using a piston extending partially outside the tank, the piston being attached to an actuator located at least outside the tank for pushing and pulling the piston,cooling the feed liquid near freezing point;expanding the feed liquid adiabatically to essentially normal pressure forming a mixture of ice and liquid brine;removing and collecting the liquid brine;feeding product liquid forming a second mixture of ice and product liquid;pressurizing the second mixture to high pressure;using the second mixture to cool feed liquid under high pressure expanding the second mixture adiabatically to essentially normal pressure; andremoving the second mixture from the tank as the product liquid.

The present disclosure relates to a method for crystallization of an active pharmaceutical ingredient (API), where the crystallization and crystal growth are controlled. According to the method, an aqueous solution comprising a solid amorphous nano-sized API and one or more polymers and / or copolymers are contacted to form a suspension comprising the nano-sized API in a crystalline form.

The present invention relates to a three-phase methodology to obtain a highly concentrated, purified chemical component from plant material in an industrial setting. The three phases of the methodology of the present invention include Phase 1 : Preparing and solubilization, Phase 2: Separation and Salting and Phase 3: crystallization. The methodology results in dried composition purified from a plant material having at least 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% of the chemical component by weight.

A method of manufacturing a particulate transition metal carbonate material is described. The method includes mixing a transition metal precursor salt with a second salt in a liquid vehicle. A precipitation reaction is then performed to form a slurry of the particulate transition metal carbonate material in the liquid vehicle. The particulate transition metal carbonate material may find use as seeds in a subsequent precipitation reaction. Methods of manufacturing a particulate precursor materials are also described, including performing a precipitation reaction between one or more transition metal sources in the presence of seed particles in a reaction mixture within a precipitation reaction vessel, to form the particulate precursor material by precipitation onto the surface of the seed particles.

A method of manufacturing a particulate precursor material, comprising providing a suspension of seed particles in a liquid vehicle. A precipitation reaction involving one or more transition metal sou

A hydrate of a VEGFR inhibitor, a crystal form thereof and a preparation method therefor are provided. The VEGFR inhibitor is 6-(6,7-dimethoxyquinazolin-4-yl-oxy)-N,2-dimethylbenzofuran-3-carboxamide, and the hydrate and the crystal form thereof have good physicochemical properties, and have good flowability, solubility, stability and bioavailability, and alleviated hygroscopicity. In addition, the preparation method is simple, has good repeatability, achieves high yield, and is easy to perform and environment-friendly, and the method requires only a small amount of solvents and facilitates recycling use, thus effectively reducing the cost on reagents, and enabling easy implementation of large-scale mass production.

A system for separating a mineral from a clay using a gas injection module includes a solution tank configured to receive a supersaturated solution including at least one mineral. The system also includes a gas injection module in fluid communication with the solution tank and configured to receive at least a portion of the supersaturated solution. The system includes at least one gas injection port in fluid communication with a source of gas and the gas injection module. The gas injection port is configured to inject a gas to the supersaturated solution. During operation of the system, the gas causes at least a portion of the supersaturated solution to crystallize.

The invention belongs to the technical field of ship rust removal, and particularly relates to an abrasive self-generating jet device and method using seawater crystallization and application, the device comprises a seawater purification system, a crystallization system connected with the seawater purification system, and an injection system connected with the crystallization system; the seawater purification system is used for sequentially carrying out desalination separation, strong brine evaporation concentration and supersaturated salt solution preparation on seawater, and the crystallization system is used for preparing an abrasive material from the supersaturated salt solution and sending the abrasive material to the injection system for spraying and derusting; the crystallization system comprises an ultrasonic crystallization controller, the ultrasonic crystallization controller is controlled by a control cabinet, the ultrasonic crystallization controller comprises a cylindrical cavity, a spoiler is arranged in the center of the cavity, a plurality of ultrasonic fractional crystallization particle size generators are arranged on the inner wall of the cavity, and each ultrasonic fractional crystallization particle size generator is electrically connected with the control cabinet; the ultrasonic fractional crystallization particle size generator comprises a large-particle-size salt crystal generation assembly located at the bottom and a small-particle-size salt crystal generation assembly located on the upper portion, and further comprises a rotating platform located on the top and a damper located above the rotating platform and provided with an ultrasonic transmitting hole. According to the invention, the supersaturated salt solution forms salt crystals with large particle size, small particle size and uniform particle size in the ultrasonic crystallization controller through the ultrasonic fractional crystallization particle size generator and the rotating platform, and seawater crystals are adopted to replace chemically synthesized abrasives or artificially prepared abrasives, so that the problem of environmental pollution caused in the use process of the abrasives can be effectively solved.

A method of manufacturing a particulate transition metal carbonate material. A transition metal precursor salt in a liquid vehicle is mixed with a carbonate salt and / or a bicarbonate salt, and a preci

The application belongs to the technical field of chemical industry, and particularly relates to an ultrasonic-assisted melt crystallization method. The ultrasonic-assisted melt crystallization method sequentially comprises a cooling crystallization process and a sweating process. The cooling crystallization process comprises a first cooling stage and a second cooling stage. The cooling rate of the first cooling stage is greater than that of the second cooling stage. The ultrasonic wave is used to assist the crystallization of the material to be purified at the beginning of the first cooling stage or the beginning of the second cooling stage. The frequency of the ultrasonic wave is reduced when the crystal appears. The application can promote the nucleation of the material by using the ultrasonic wave to disturb the material at the beginning of the first cooling stage or the beginning of the second cooling stage, reduce the impurities in the crystal, shorten the nucleation time, and increase the cooling rate. The frequency of the ultrasonic wave is reduced when the crystal appears, which can improve the integrity of the crystal and the purity of the product.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The present application belongs to the field of material instruments, and particularly relates to a crystallization compound for SiC and melamine ultrasonic. The compound comprises a compound cup, an ice bath pot and a bottom plug. The compound cup is composed of a compound wall, a cup rim, a vibration transmission pipe and a pipe rim. The upper part of the compound wall is provided with the cup rim. The bottom of the compound wall is provided with the vibration transmission pipe, and the top of the vibration transmission pipe is provided with the pipe rim. The ice bath pot comprises a pot bottom, a pot wall, a pot rim and a connecting pipe. The upper part of the pot bottom is provided with the connecting pipe. The connecting pipe can be sealingly inserted into the vibration transmission pipe. The upper part of the pot bottom is the pot wall, and the upper part of the pot wall is provided with the pot rim. The pot rim sealingly cooperates with the cup rim. The upper part of the pot wall is provided with a flat pressing hole. The lower part of the bottom plug is a plug head, which sealingly cooperates with the connecting pipe. The upper part of the plug head is a limiting disc, which is clamped on the top of the connecting pipe. The upper part of the limiting disc is a plug rod, and the top of the plug rod is provided with a lifting ring. The present application is used for the crystallization compound of SiC and melamine, and has the advantages of sufficient compound and better catalytic effect of the compound material after firing.