28results about "Vibration crystallization" patented technology

A process for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C,D,S1,S2), comprising the steps of preparing (I) a supersaturated solution from said compounds, homogenizing (II) said supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a determined period, exposing said tubes (54) to a pulsed and polarized laser beam before and / or during exposure, monitoring in situ the nucleation and then the growth of co-crystals inside said tubes (54), and filtering the exposed solutions to recover co-crystals larger than a predetermined minimum size.This process is implemented to carry out co-crystallization from at least one active substance (D) and one co-former (C) in at least one first solvent (S1) and one second solvent (S2), and it further comprises two preliminary steps: establishing a phase diagram from the respective physicochemical characteristics of said active substance (D), said co-former (C), said first solvent (S1) and said second solvent (S2), and then determining, from said phase diagram thus established, concentration, temperature and exposure conditions providing a stable phase for the production of co-crystals. See Figure 4.

Method for producing electronic grade nickel sulfate from nickel powder, crystallization apparatus, and control thereof The present invention provides a method for producing nickel sulfate, and nickel sulfate produced thereby. The process includes acid leaching, copper removal, acid adjustment, concentration, cooling crystallization, drying and sieving, and secondary leaching. Oxidation In the calcination furnace, the temperature is 400 to 700°C, and 1 kg of compressed air is used for each kilogram of nickel powder. ~5m 3 The reaction time is 1.0 to 2.5 hours, and the temperature during acid immersion is controlled to 45 to 70°C. Then, add dilute sulfuric acid to control the pH to 0.5-1.5 and react for 1-3 hours. The copper removal is to replace the copper with nickel powder, and the acid conditioning is to use nickel hydroxide or The pH is adjusted to 2.5-4.5 using nickel carbonate, and the filtrate is concentrated by The cooling crystallization method is to obtain nickel sulfate crystals and return the mother liquor to the concentrate. Drying and sieving is to add the undersieved material to the crystallizer as seed crystals, and secondary leaching is to Dilute sulfuric acid is added to the leaching slag, and it is reacted with nickel sulfate or hydrogen peroxide until nickel is less than 0.1%. If the first stage is full, the second leaching is continued. The crystallizer is a crystallizer that is connected in series with a second-stage crystallizer and a third-stage crystallizer. A crystallization frame, an oscillator provided under the crystallization frame, and an oscillator provided at the exit end of the crystallization frame. The crystallization frame is a rectangular parallelepiped. The bottom of the ribs are evenly spaced, with a cross section of a circular arc. The distance between two adjacent ribs is S is 1 / 25 to 1 / 15 of the width of the crystallization frame, and either the width b or the height h of the rib The width of the crystallization frame is 1 / 100 to 1 / 150 of the width of the crystallization frame. It does not add any new impurity ions, and does not add any oxidizing agent. The nickel sulfate crystal particles produced are uniform and are free of the static generation. This avoids caking of very large particles, irregularly shaped particles and crystals.

The invention discloses a crystallization device, a brine lithium extraction system and a process thereof, and relates to the technical field of lithium ion recovery, the crystallization device comprises a crystallizer body, a stirring mechanism and a first vibration element, the crystallizer body is internally used for accommodating slurry, a feeding part on the crystallizer body is used for introducing a sodium carbonate solution and brine, and a discharging part on the crystallizer body is used for discharging lithium carbonate crystal slurry; the stirring mechanism is used for stirring slurry in the crystallizer body; the first vibration element is arranged on the side wall of the crystallizer body and can apply mechanical vibration to the crystallizer body, on one hand, strong fluid disturbance can be generated in mixed feed liquid of brine and a sodium carbonate solution, and mixing and mass transfer between the brine and the sodium carbonate solution are enhanced; on the other hand, the concentration gradient between solid-liquid phases and the concentration gradient inside feed liquid can be destroyed, local supersaturation areas are avoided, the uniformity of crystal nucleation growth is improved, on the other hand, the physical adsorption force and chemical bonding between crystal nuclei and the inner wall of the crystallizer body can be destroyed, and the nucleation growth efficiency of crystals is improved.

The invention relates to a method for producing a polymorphic or pseudo-polymorphic crystalline phase from a plurality of compounds (C, D, S1, S2), the method comprising steps of preparing (I) a supersaturated solution from the compounds, homogenizing (II) the supersaturated solution in an ultrasonic bath, transferring (III) the supersaturated solution into a plurality of heated tubes (54), aging (V) the solutions transferred into the tubes for a predetermined period of time, exposing the tubes (54) to a polarized pulsed laser beam before and / or during exposure, followed in situ by nucleation and then growing cocrystals inside the tubes (54), and filtering the exposed solutions in order to recover cocrystals having a size greater than a predetermined minimum size. This method is carried out in order to obtain cocrystallization from at least one active substance (D) and a coformer (C) in at least a first solvent (S1) and a second solvent (S2).

A method of manufacturing a particulate transition metal carbonate material is described. The method includes mixing a transition metal precursor salt with a second salt in a liquid vehicle. A precipitation reaction is then performed to form a slurry of the particulate transition metal carbonate material in the liquid vehicle. The particulate transition metal carbonate material may find use as seeds in a subsequent precipitation reaction. Methods of manufacturing a particulate precursor materials are also described, including performing a precipitation reaction between one or more transition metal sources in the presence of seed particles in a reaction mixture within a precipitation reaction vessel, to form the particulate precursor material by precipitation onto the surface of the seed particles.

This invention discloses an ultrasonic-cold finger coupled plate melt crystallizer and a continuous purification process. The crystallizer body includes multiple heat exchange plates, each with a built-in serpentine refrigerant channel; multiple ultrasonic vibrating plates are sequentially arranged around the shell of the plate melt crystallizer to provide an ultrasonic field covering the entire crystallizer body; at least one cold finger assembly is located on top of the plate melt crystallizer and connected to the upper cover plate of the crystallizer body via a detachable flange. The cold finger assembly includes an inlet manifold, an outlet manifold, a cold finger body, and an ultrasonic probe. The inlet and outlet manifolds are arranged parallel to each other above the crystallizer body along a second direction. The bottom of each cold finger body is located within the crystallizer body, and its top two ends are connected to the inlet and outlet manifolds, respectively. The ultrasonic probe extends along a third direction and is inserted into the interior of the cold finger body. Using the melt crystallizer and process of this invention enables higher crystallization efficiency and greater product yield.

The invention discloses an experimental device for a drug crystallization process. The experimental device comprises a reactor, a lifting probe assembly, a crystallization guide assembly and a control system. The reactor comprises a reaction kettle and a heating base which are in heat conduction connection; the lifting probe assembly is mounted on the reaction kettle and can extend below the liquid level to shoot crystal images; the crystallization guide assembly comprises a rotary driving mechanism, a shaft tube, a first ultrasonic transducer, a second ultrasonic transducer, a focused light beam reflection measuring instrument, a turbidity sensor and a stirring piece; wherein the frequency of the first ultrasonic transducer is lower than that of the second ultrasonic transducer, and the first ultrasonic transducer and the second ultrasonic transducer are used for inducing nucleation and fine grain elimination; the focused beam reflection measuring instrument monitors the number and granularity of crystals; the heating base, the lifting probe assembly, the rotary driving mechanism, the first ultrasonic transducer, the second ultrasonic transducer, the focused light beam reflection measuring instrument and the turbidity sensor are all electrically connected with the control system, so that monitoring and control of the experiment process are realized, the crystallization efficiency is effectively improved, and high-quality crystals are obtained.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The application discloses a kind of ultrasonic reinforced C8 aromatic hydrocarbon crystallization separation method and system, belong to C8 aromatic hydrocarbon separation technical field.The system of the present application mainly includes primary crystallizer, centrifugal filter, melting tank, ultrasonic generator and the like device.According to the different separation requirements of raw material, different process flow and process system are used in the present application, two-stage filtration process and the combination process of fine filtration are first proposed in C8 aromatic hydrocarbon separation, and the separation of ethylbenzene and xylene can be realized through primary crystallization and filtration, with high separation purity;At the same time, the present application can select coarse separation or fine separation according to the purity requirement of process product, and the raw material has wide adaptability and flexible process.

A method of manufacturing a particulate precursor material, comprising providing a suspension of seed particles in a liquid vehicle. A precipitation reaction involving one or more transition metal sou

The invention relates to the technical field of devitrification cooling, and discloses an ultrasonic-assisted benzohydroxamic acid rapid devitrification cooling device which comprises a cooling cover, a condensation pipe is mounted at the position, located at the lower edge of a mounting groove, in the cooling cover, first through holes are formed in the middle positions of the two sides of the inner wall of the cooling cover, and second through holes are formed in one sides of two baffles. During centralized cooling, air flow cooled by the condensation pipe can only be exhausted from the exhaust groove for centralized cooling, and when the number of high-temperature operation areas on the ultrasonic-assisted equipment is large, the air flow can only be exhausted through the second butt joint covers, hoses and the like, so that the high-temperature operation areas of the ultrasonic-assisted equipment are reduced, and the cooling efficiency is improved. And the electric push rod is started to push the baffle to communicate the first through hole with the first butt joint cover through the second through hole, low-temperature airflow of the cooling cover passes through the third butt joint cover, part of the low-temperature airflow is blown into other areas of the equipment, a devitrification cooling device does not need to be additionally installed, and the cooling and temperature control cost of the ultrasonic-assisted equipment is reduced.

A method for purification of feed liquid containing minerals or chemicals or both, having steps offeeding feed liquid into a tank and pressurizing the feed liquid to a high pressure using a piston extending partially outside the tank, the piston being attached to an actuator located at least outside the tank for pushing and pulling the piston,cooling the feed liquid near freezing point;expanding the feed liquid adiabatically to essentially normal pressure forming a mixture of ice and liquid brine;removing and collecting the liquid brine;feeding product liquid forming a second mixture of ice and product liquid;pressurizing the second mixture to high pressure;using the second mixture to cool feed liquid under high pressure expanding the second mixture adiabatically to essentially normal pressure; andremoving the second mixture from the tank as the product liquid.

A method of manufacturing a particulate transition metal carbonate material is described. The method includes mixing a transition metal precursor salt with a second salt in a liquid vehicle. A precipitation reaction is then performed to form a slurry of the particulate transition metal carbonate material in the liquid vehicle. The particulate transition metal carbonate material may find use as seeds in a subsequent precipitation reaction. Methods of manufacturing a particulate precursor materials are also described, including performing a precipitation reaction between one or more transition metal sources in the presence of seed particles in a reaction mixture within a precipitation reaction vessel, to form the particulate precursor material by precipitation onto the surface of the seed particles.

A method of manufacturing a particulate precursor material, comprising providing a suspension of seed particles in a liquid vehicle. A precipitation reaction involving one or more transition metal sou

A hydrate of a VEGFR inhibitor, a crystal form thereof and a preparation method therefor are provided. The VEGFR inhibitor is 6-(6,7-dimethoxyquinazolin-4-yl-oxy)-N,2-dimethylbenzofuran-3-carboxamide, and the hydrate and the crystal form thereof have good physicochemical properties, and have good flowability, solubility, stability and bioavailability, and alleviated hygroscopicity. In addition, the preparation method is simple, has good repeatability, achieves high yield, and is easy to perform and environment-friendly, and the method requires only a small amount of solvents and facilitates recycling use, thus effectively reducing the cost on reagents, and enabling easy implementation of large-scale mass production.

A method of manufacturing a particulate transition metal carbonate material. A transition metal precursor salt in a liquid vehicle is mixed with a carbonate salt and / or a bicarbonate salt, and a preci

The application belongs to the technical field of chemical industry, and particularly relates to an ultrasonic-assisted melt crystallization method. The ultrasonic-assisted melt crystallization method sequentially comprises a cooling crystallization process and a sweating process. The cooling crystallization process comprises a first cooling stage and a second cooling stage. The cooling rate of the first cooling stage is greater than that of the second cooling stage. The ultrasonic wave is used to assist the crystallization of the material to be purified at the beginning of the first cooling stage or the beginning of the second cooling stage. The frequency of the ultrasonic wave is reduced when the crystal appears. The application can promote the nucleation of the material by using the ultrasonic wave to disturb the material at the beginning of the first cooling stage or the beginning of the second cooling stage, reduce the impurities in the crystal, shorten the nucleation time, and increase the cooling rate. The frequency of the ultrasonic wave is reduced when the crystal appears, which can improve the integrity of the crystal and the purity of the product.

The disclosure relates to methods for crystallization of active pharmaceutical ingredients (APIs), wherein the crystallization and crystal growth is controlled. According to the method solid amorphous nanosized API and an aqueous solution comprising one or more polymers and / or copolymers are contacted so as to form a suspension comprising nanosized API in crystalline form.

The invention belongs to the technical field of purification, and particularly relates to a continuous oscillation crystallization method and device. The continuous oscillation crystallization method provided by the invention comprises the following steps: periodically and alternately carrying out oscillation dissolution and oscillation crystallization on a material to be crystallized. Compared with the prior art, the method provided by the invention has the following advantages: the material alternately flows through and is heated and cooled, so that the crystal form and the size distribution of the crystal can be controlled, the scaling of the reactor can be inhibited, and the self-cleaning effect is achieved; according to the method, periodic temperature oscillation is used as a dynamic grading and selecting mechanism (dissolution-growth circulation screening), fine grains are actively removed, growth of crystals with target granularity is promoted, and crystal granularity uniformity (CSD narrowing) is achieved; periodic high-temperature breaking effectively prevents formation of peritectic and twin crystals, and the fluidity and dispersity of the product are remarkably improved.

The application discloses a kind of old polyester textile alcoholysis spinning regeneration process, including the following steps, first, old textile scrap is put into reaction tank, then methanol is added to reaction tank to decompose old textile, the product after decomposition is crystallized by cooling, then the crystallization solid and liquid in the reaction tank are entered into tank body, then separation and filtration are carried out by the guide separation mechanism arranged in the tank body, the filtered liquid is discharged from the discharge hopper at the bottom of the tank body, and the crystalline obtained from the top of the tank body is subjected to polymerization and re-spinning processing to obtain fiber;The application combines reaction tank, guide filter, knocking member and heating member, which does not affect the decomposition of old textile scrap, but also improves the filtration efficiency of the crystalline and the remaining liquid generated by decomposition, allows the crystalline to dry quickly and crystallize, and the crystalline after drying is subjected to polymerization and spinning regeneration processing, to improve the overall efficiency of old textile alcoholysis regeneration.

The application provides a particle size control method for ultrasonic-assisted gamma-aminobutyric acid crystallization. After impurity removal and decolorization of a gamma-aminobutyric acid feed liquid, the feed liquid is concentrated to a near-saturated state through heating and stirring, then ultrasonic-assisted crystallization is performed, cooling and temperature reduction are performed, aging is performed, and crude crystals are obtained through suction filtration, and finally, the target crystals are obtained through washing and drying. The method is a synergistic process of raw material liquid pretreatment, evaporation concentration-ultrasonic-cooling coupled crystallization, aging and post-treatment, uses ultrasonic cavitation effect to reduce nucleation potential barrier, and combines supersaturation precision control and gradient cooling strategies to realize crystal particle size refinement, obvious narrowing of particle size distribution and effective inhibition of agglomeration, so that the median particle size of the crystals can be controlled to be less than or equal to 200 microns, the particle size distribution span is less than or equal to 1.5, the agglomeration phenomenon is significantly inhibited, the crystal form remains stable, the crystal habit is complete and smooth, the crystal product quality and process efficiency are significantly improved, and the method has important industrial application value.

A hydrate of a VEGFR inhibitor, a crystal form thereof and a preparation method therefor are provided. The VEGFR inhibitor is 6-(6,7-dimethoxyquinazolin-4-yl-oxy)-N,2-dimethylbenzofuran-3-carboxamide, and the hydrate and the crystal form thereof have good physicochemical properties, and have good flowability, solubility, stability and bioavailability, and alleviated hygroscopicity. In addition, the preparation method is simple, has good repeatability, achieves high yield, and is easy to perform and environment-friendly, and the method requires only a small amount of solvents and facilitates recycling use, thus effectively reducing the cost on reagents, and enabling easy implementation of large-scale mass production.

Described are liquid compositions that contain a desired (e.g., extracted) plant material such as cannabinoid, terpene, terpenoid, or the like, contained, e.g., dissolved, suspended, or emulsified, in the liquid, which contains surfactant; methods of preparing these types of liquid compositions; and methods of processing this type of liquid composition to collect, isolate, concentrate, or purify a desired target material contained in the liquid composition.

Method for separating salts from biomass. This description relates to a salt separator (100) for separating salts from a carbonaceous material comprising: - a chamber including a side wall (101), a lid (102) and a bottom (103), delimiting an inner chamber (105), - a precipitation structure (140), for example rough, alveolar, particulate, perforated or porous, positioned in the inner chamber (105), on which, when biomass is injected into the inner chamber (105), the salts contained in the biomass precipitate, - an ultrasonic probe (120), positioned in the inner chamber (105) or outside the chamber against the side wall (101), the bottom (103) or the lid (102), configured to detach the salts precipitated on the precipitation structure (140) when it emits ultrasound,- heating means (130) configured to heat at least the precipitation structure (140) to a temperature above 374°C. Figure for the abstract: Fig. 1,

The present application relates to the technical field of industrial solid waste resource utilization, and particularly relates to a system for extracting high-purity potassium salt by using cement bypass ash, which comprises: a magnetic separation module for separating Fe3O4 magnetic phase in the bypass ash under a 0.8-1.2T gradient magnetic field, a dynamic activation module for two-stage calcination under the assistance of NH4Cl, a countercurrent leaching module for realizing hydrochloric acid-ammonium fluoride synergistic leaching under the condition of pH 0.5-2.5 through a three-stage series reactor, an ion sieve separation module comprising a bipolar membrane electrodialysis unit and a Li + type K-LTL molecular sieve adsorption tower, and a crystal phase regulation module for preparing potassium salt crystals with Cl ‑ content ≤0.1% by using real-time feedback of super-saturation through conductivity; and a cyclic regeneration module. After purification, the potassium salt in the present application can be directly packaged and sold in the market, and the remaining bypass ash can continue to be reused to produce cement, and the comprehensive cost is reduced by more than 35% compared with the traditional process, thereby providing an integrated solution of “efficient potassium extraction-high-purity separation-zero waste recycling” for the solid waste of the cement industry.

The invention relates to a method for optimizing stannous sulfate crystallization by actively regulating and controlling cavitation bubble dynamic behaviors through cooperation of ultrasound and a negative pressure field, and belongs to the technical field of inorganic salt crystallization control. In order to solve the problems that in the prior art, ultrasonic cavitation is difficult to regulate and control, and explosive nucleation is prone to occurring in traditional negative pressure evaporation, an optimized crystallization mechanism of cavitation threshold regulation and bubble optimization regulation is adopted, the cavitation threshold of liquid is remarkably reduced by constructing a negative pressure environment, a controlled cavitation bubble group is generated through induction of low-power-density ultrasonic waves, and the cavitation effect of the liquid is improved. The two types of cavitation bubbles are precisely regulated and controlled, the steady-state cavitation bubbles are used as heterogeneous nucleation sites, nucleation energy barriers are reduced, and crystals are induced to grow orderly; and micro-jet generated by collapse of transient cavitation bubbles is utilized to strengthen mass transfer and scatter soft aggregates. According to the method, the contradiction between thermodynamics and dynamics in the crystallization process is solved through a physical field coupling means, crystal agglomeration acceleration is effectively inhibited, and the stannous sulfate product which is narrow in particle size distribution, high in density and regular in morphology is prepared.

The invention relates to environment-friendly and energy-saving recycling mirabilite removal equipment in chromium liquid, which comprises an enamel tank, a feeding hole is formed in the upper end of the enamel tank, a material external connecting pipe is arranged in the feeding hole, and a driving mechanism is arranged in the enamel tank; the method is particularly suitable for being used and has a relatively high commercial prospect; according to the chromium liquid recovery device, existing chromium liquid recovery equipment is improved and modified, in the mirabilite removal process, the material external connection pipe can be unblocked, mirabilite crystals are prevented from being deposited at a discharging port of the material external connection pipe, and therefore the situation that the material external connection pipe is blocked is avoided, and the service life of the material external connection pipe is prolonged. Therefore, the equipment does not need to be unblocked and cleaned, so that the production efficiency is effectively improved.

Technology is disclosed for a method for performing crystallization, where the method may include utilizing a software algorithm, and perform a crystallization process using the software algorithm.