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Compound antithyroid gel for external application and preparation method thereof

An anti-thyroid and gel technology, which is applied in the field of medicine, can solve problems such as the separation of the drug from the matrix during storage time, the decline in the use effect of the patient, and the impact on the stability of the drug, so as to facilitate the release and absorption of the drug, rich blood flow, The effect of reducing adverse reactions

Inactive Publication Date: 2012-08-15
张蔚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A class is emulsifiable cream or ointment, such as CN1084078A, CN1085079A and CN1692940A, the defect of disclosed preparation is: (1) these emulsifiable pastes and ointment have many problems in production practice: due to the need heating of medicine and part matrix and temperature deviation High, if the storage time is too long, it will easily cause the separation of the drug and the matrix, which will affect the stability of the drug and reduce the use effect of the patient
Patch and ointment or cream have common disadvantages: the medication site is on the neck, and they will have obvious traces or residues on the exposed part of the human body after medication or even after the drug penetrates, and even because of the shedding phenomenon, it will affect the skin. treatment effect
Many people will choose to use intermittently from time to time, which will affect the treatment of diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Methimazole 0.5g

[0029] Hydrocortisone Sodium Succinate 0.25g

[0030]Carbomer 1.0g

[0031] Triethanolamine 1.0g

[0032] Propylene glycol 5.0g

[0033] Glycerin 10.0g

[0034] Azone 1.0ml

[0035] PEG-4000.5g

[0036] Cysteine ​​0.1g

[0037] Ethylparaben 0.1g

[0038] Add ethanol to 100g

[0039] making process:

[0040] 1. Wet 1g of carbomer with a small amount of solvent, and then gradually add solvent to grind to make it fully swell;

[0041] 2. Slowly add 1g of triethanolamine dropwise and grind until uniform;

[0042] 3. Take 5g of propylene glycol and 10g of glycerin and mix until uniform;

[0043] 4. Add 0.5g of methimazole into an appropriate amount of ethanol to dissolve, add 0.25g of hydrocortisone sodium succinate into an appropriate amount of pure water to dissolve, mix the two solutions, add 0.5g of PEG-4000 and stir well; add propylene glycol glycerin mixture respectively , Cysteine ​​0.1g, Azone 1.0ml, Ethylparaben 0.1g, stir evenly, add ...

Embodiment 2

[0045] Embodiment 2 (summer special type)

[0046] Methimazole 1.0g

[0047] Dexamethasone acetate 0.025g

[0048] Carbomer 1.0g

[0049] Triethanolamine 1.0g

[0050] Propylene glycol 8g

[0051] Glycerin 10g

[0052] Menthol (or borneol) 0.01g

[0053] Sorbitol 0.1g

[0054] Pure water (distilled water) to 100g

[0055] making process:

[0056] 1. Sprinkle 1g of Carbomer on the liquid surface of about 50ml of pure water (below 40°C) and leave it overnight to make it fully swell and avoid agglomeration;

[0057] 2. Slowly add 1 g of triethanolamine dropwise and grind; add 0.025 g of dexamethasone acetate and grind until uniform; 3. Add 1.0 g of methimazole into an appropriate amount of pure water and stir to dissolve. Then add 8 g of propylene glycol, 10 g of glycerin, 0.01 g of menthol (or borneol), and 0.1 g of sorbitol one by one, stir evenly, add water to volume, stir evenly, and make a mixed solution;

[0058] 4. Slowly add the mixed solution (3) into the car...

Embodiment 3

[0060] Methimazole 2.0g

[0061] Triamcinolone acetonide acetate 0.025g

[0062] Carbomer 1.0g

[0063] Triethanolamine 1.5g

[0064] Propylene glycol 10.0g

[0065] Glycerin 10.0g

[0066] Azone 1.0ml

[0067] Methylparaben 0.05g

[0068] Pure water (distilled water) to 100g

[0069] making process:

[0070] 1. Sprinkle 1g of carbomer on the surface of 10g of glycerin, grind evenly until completely mixed. Add 20-30ml of water and grind until fine, then add 30-40ml of water and let stand to fully swell the carbomer to make a mixed solution 1;

[0071] 2. Slowly add 1 g of triethanolamine dropwise, grind until uniform, add 0.025 g of triamcinolone acetonide, and grind until uniform;

[0072] 3. Add 2.0 g of methimazole into an appropriate amount of pure water, and stir to dissolve. Then add propylene glycol 10g, azone 1.0ml,

[0073] Methylparaben 0.05g, stir evenly, add water to volume, stir evenly to make a mixed solution;

[0074] 4. Slowly add the mixed solution...

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PUM

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Abstract

A compound antithyroid gel for external application comprises an antithyroid drug, adrenal glucocorticoid, and a drug penetration enhancer. When in use, the gel is directly and externally applied to skin at the anterior cervical thyroid site. The drug directly penetrates into thyroid through skin to treat hyperthyroidism; the using amount of the drug is less; the curative effect is quick; and no systemic drug side effect is caused to human body. When the compound antithyroid gel of the invention is used for the treatment of hyperthyroidism, the repeated incidence and recurrence incidence of hyperthyroidism are low; the treatment effect is improved; and patient pain is relieved. The compound antithyroid gel is a safer and more effective drug for treating hyperthyroidism.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound anti-thyroid gel for external application and a preparation method thereof. Background technique [0002] Hyperthyroidism is a syndrome caused by excessive secretion of thyroid hormone. It is characterized by goiter, increased basal metabolism and abnormalities of the autonomic nervous system. Hyperthyroidism is a frequently-occurring and common disease, and most patients are women. The systemic adverse reactions of oral antithyroid drugs in clinical treatment mainly include: ① Leukopenia and neutropenia, the incidence rate is about 10%, and agranulocytosis may occur in severe cases. It mainly occurs 2 to 3 months after the start of treatment. Once agranulocytosis occurs, the drug must be stopped immediately, and the same kind of hyperthyroid drug can no longer be used after the patient recovers. ② The incidence of drug-induced rash is about 2 to 3%. For patients...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K45/00A61K47/32A61K47/34A61K47/36A61K47/38A61P5/16
Inventor 张蔚
Owner 张蔚
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