35 results about "Methimazole" patented technology

The invention belongs to the technical field of medicine and health and relates to a preparation method of a nanogold-containing antibacterial agent. The preparation method comprises the following steps that A, egg white is centrifuged, liquid supernatant is taken, and a reactant A is obtained; B, under the temperature condition of 20-30 DEG C, distilled water is added in the reactant A obtained in the step A to dilute till the mass fraction is 1-5%, a sodium hydroxide solution is used for adjusting the pH to be 9-11, uniform mixing is conducted, and a mixed solution is obtained; C, under thetemperature condition of 80-100 DEG C, a chloroauric acid solution is added in the mixed solution obtained in the step B to react for 20-30 min, and then a nanogold-containing solution is obtained; and D, under the temperature condition of 80-100 DEG C, a methimazole solution is added in the nanogold-containing solution obtained in the step C, stirring and mixing are conducted, and after reaction,the nanogold-containing antibacterial agent is obtained. The nanogold-containing antibacterial agent has the excellent antibacterial property and biocompatibility, the safety and reliability are achieved, and the preparation method of the nanogold-containing antibacterial agent is simple.

The invention provides a methimazole detection method, which comprises the following steps of mixing methimazole with a first AuNPs solution to obtain a mixed solution; irradiating a first mixed solution formed by mixing the mixed solution with a first fluorescent N/S-CQDs solution with ultraviolet light to obtain a fluorescence spectrogram of the first mixed solution; irradiating a second mixed solution formed by mixing a second AuNPs solution and a second fluorescent N/S-CQDs solution with ultraviolet light to obtain a fluorescence spectrogram of the second mixed solution; obtaining the content of the methimazole according to the fluorescence spectrogram of the first mixed solution and the fluorescence spectrogram of the second mixed solution. The methimazole detection method provided by the invention uses the fluorescent N/S-CQDs as energy donors and AuNPs as energy receptors to construct a complex fluorescent probe, and the methimazole is detected by using the complex fluorescent probe. Compared with high performance liquid chromatography, flow injection spectrophotometry and the like, the cost is low, and the operation is easy.

The invention relates to a preparation method of methimazole. The method specifically comprises the following step: enabling reaction of N-methylimidazole, N-butyllithium and powdered sulfur in an organic solvent to obtain methimazole. The preparation method disclosed by the invention is simple in process, mild in condition, simple to operate, easy for post treatment, applicable for industrialized production, and capable of greatly improving the reaction yield of methimazole.

The invention relates to methimazole microemulsion, methimazole microemulsion-based gel and a preparation method and application of the methimazole microemulsion. The methimazole microemulsion comprises methimazole, oil, surfactant, cosurfactant, water and transdermal Enhancer according to a weight ratio of 1:(1.40-4.25):(5.13-15.45):(5.13-15.45):(1.40-8.32):(0.26:1.26). The methimazole microemulsion-based gel is prepared by adding gel matrix into the methimazole microemulsion, allowing swelling and performing uniform mixing. The methimazole microemulsion and the methimazole microemulsion-based gel are directly applicable to affected parts, are also applicable to the preparation of hyperthyroidism pharmaceuticals such as patches or plasters, and have the advantages such as good solubility, high penetration capacity, long acting time, evident improvement in therapeutic effect, fewer times of administration, and convenience of administration.

The invention belongs to the field of medicines, and discloses application of methimazole in serving as and/or preparation of a metal beta-lactamase inhibitor. The invention discloses the application of the methimazole and/or the derivative thereof in serving as and/or preparation of the metal beta-lactamase inhibitor for the first time, the methimazole and/or the derivative thereof has a good inhibition effect on metal beta-lactamase, can protect antibiotics from being degraded by bacteria, improves the sensitivity of the bacteria to the antibiotics, and reversing drug resistance of the bacteria to the antibiotics; and meanwhile, the methimazole and/or the derivative thereof have a good synergistic effect when being combined with the antibiotics, and can be used as an adjuvant drug for inhibiting the bacteria. The methimazole has small toxic and side effects on human bodies under normal clinical use dosage, and has good safety in many years when being clinically used as a medicine for treating hyperthyroidism.

The invention relates to an enzyme linked immunosorbent assay kit for detecting methimazole residues in animal-derived food. The kit comprises the following components according to proportion: a coating plate, a standard substance, an enzyme-labeled substrate working solution, a substrate solution A, a substrate solution B, a terminating solution, a concentrated washing liquid and a concentrated extract. The kit sensitivity is 0.3 ppb, and the precision is as follows: intra assay variation coefficient (CV%) is 5%, and inter assay variation coefficient (CV%) is 10%; the accuracy is shown by recovery rate, and the recovery rate is in the range of 80-110%. IC 50 range is between 0.3 and 0.5 ppb, and the linear correlation coefficient |r| is not less than 0.9900, and the kit has the advantages of wide usage scope, convenient usage and accurate detection.

The invention provides a nanogold colorimetric method based on an anti-agglomeration principle and a method for determining the content of silver ions in a water sample by using the nanogold colorimetric method. The method comprises the following steps: taking 200 [mu] L of a nanogold solution prepared by reduction of sodium citrate, adding 200 [mu] L of a methimazole solution with a certain concentration, adding 400 [mu] L of a BR buffer solution, carrying out uniform shaking incubation for 5 min, carrying out ultraviolet-visible spectrum scanning, determining the absorbance of the solution at 520 nm and 660 nm, and taking the absorbance ratio A520/A660 of the solution as A0; taking 200 [mu] L of methimazole with a certain concentration and 200 [mu] L of a silver ion solution with a certain concentration; adding 200 [mu] L BR buffer solution, shaking incubation for 10 minutes, adding 200 [mu] L of a nanogold solution; shaking and incubating for 5 minutes, carrying out ultraviolet-visible spectrum scanning, determining the absorbance of the solution at 520 nm and 660 nm, using the absorbance ratio A520/A660 of the solution as A1, and the change of the absorbance ratio after the silver ions are added is in linear relation with the concentration of the silver ions so that the content of the silver ions in the water sample can be rapidly, sensitively and accurately measured. The method is good in selectivity, high in sensitivity and wide in detection range, only an ultraviolet spectrophotometer is needed for measurement without a large instrument, the operation requirement islow and the method has wide application prospects.

The invention relates to the field of material, optics and environment detection, in particular to a silver-plated optical fiber Raman probe as well as a preparation method and application thereof, and methimazole is adopted as a Raman signal molecule to realize Cr (VI) detection. According to the silver-plated optical fiber Raman probe disclosed by the invention, the methimazole functionalization is adopted, so that the ultra-sensitive detection of Cr (VI) and the excellent oxidation resistance are realized. The preparation method disclosed by the invention is simple in process, high in sensitivity, good in repeatability, good in stability and good in anti-interference performance, and by adopting a stannous chloride assisted solvothermal method, morphology regulation and control of the silver nanoparticles on the end face of the optical fiber and strong interface adhesion of the optical fiber and the silver nanomaterial are realized. Specifically, the stannous chloride pretreatment process promotes compact and uniform growth of silver nanoparticles on the end face of the optical fiber on one hand, and enhances interface adhesion of the optical fiber and the silver nanoparticles on the other hand. By adopting methimazole functionalization, ultra-sensitive detection and excellent oxidation resistance of Cr (VI) are realized.

The invention provides a preparation method of a hedysarum polybotrys polysaccharide functionalized silver nanoparticle colorimetric sensor, which comprises the following steps: heating a silver nitrate solution to 60-90 DEG C, adjusting the pH value to 8-14, quickly adding a hedysarum polybotrys polysaccharide solution at one time under stirring for reaction, stopping heating and cooling until the solution is changed from transparent to orange yellow, and filtering to obtain a silver nitrate solution; the hedysarum polybotrys polysaccharide functionalized silver nanoparticle colorimetric sensor is obtained. An injector paper-based methimazole colorimetric detection device prepared by applying the hedysarum polybotrys polysaccharide functionalized silver nanoparticle colorimetric sensor can be used for quantitatively detecting methimazole. The detection device is low in cost, simple and convenient to operate, high in sensitivity and strong in specificity, is successfully applied to naked eye colorimetric detection of methimazole in human and animal serum, human and animal urine and other samples, and can realize quantitative analysis of colorimetric detection results only through naked eye observation or application of a smart phone and computer software in a real scene; or estimating the concentration of methimazole by using a colorimetric card.

The invention relates to a pharmaceutical composition for treating hyperthyroidism, a preparation containing the same, a preparation method and application thereof. The pharmaceutical composition contains the following active components in parts by weight: 6-12 parts of methimazole, 2800-5200 parts of kelp, 2800-5200 parts of thunberg fritillary bulb, 3500-6500 parts of coix seeds, 3500-6500 parts of cortex eucommiae, 3500-6500 parts of dogwood, 2800-5200 parts of hemlock parsley, 3500-6500 parts of airpotato yam, 4900-9100 parts of angelica sinensis and 4200-7800 parts of fermented soybeans. The pharmaceutical composition for treating hyperthyroidism provided by the invention adopts a method with combination of Chinese traditional and western medicine, gives full play to the synergistic effect of Chinese traditional and western medicine, reduces adverse reaction of the pharmaceutical composition, enhances the curative effect, shortens the course of treatment and increases tolerance of patients.

The invention discloses a medicine for treating acute pharyngitis. The medicine for treating the acute pharyngitis is prepared from the following main raw materials in parts by weight: 5 to 12 parts of cefalexin, 8 to 15 parts of methimazole, 13 to 18 parts of vitamin E, 5 to 9 parts of phenprobamate, 11 to 16 parts of analginum, 2 to 6 parts of calcium gluconate, 4 to 10 parts of acyclovir and 5 to 8 parts of bromhexine hydrochloride. The medicine disclosed by the invention is used for treating the acute pharyngitis; the medicine is convenient to take, small in side effect, has the effects of clearing heat and relieving sore throat, and has the major function of treating the acute pharyngitis; practical inspection shows that the medicine has an obvious relieving effect on the acute pharyngitis.