35 results about "Methimazole" patented technology

Methods of ameliorating episodes of accute or chronic colitis are provided by using methimazole derivatives and tautomeric cyclic thiones in combination with another pharmaceutical compound.

Treatment of autoimmune and / or inflammatory diseases associated with overexpression of Toll-like receptor 3 (TLR3) as well as Toll-like receptor 4 (TLR4) and / or TLR3 / TLR4 signaling in nonimmune cells, monocytes, macrophages, and / or dendritic cells in association with related pathologies. The use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune and inflammatory diseases associated with TLR3 as well as TLR4 and / or TLR3 / TLR4 cellular signaling in association with related pathologies is disclosed. Methods of treating a subject having a disease or condition associated with abnormal TLR-3 as well as TLR-4 and / or TLR3 / TLR4 cellular signaling in association with related pathologies are also disclosed. The present disclosure also relates to the treatment of autoimmune-inflammatory pathologies and chemokine and cytokine-mediated diseases associated with TLR overexpression and signaling. The disclosure also relates to pharmaceutical formulations capable of inhibiting the IRF-3 / Type 1 IFN / STAT / ISRE / IRF-1 pathway associated with Toll-like receptor overexpression or signaling.

The invention relates to a pharmaceutical composition for treating hyperthyroidism, a preparation containing the same, a preparation method and application thereof. The pharmaceutical composition contains the following active components in parts by weight: 6-12 parts of methimazole, 2800-5200 parts of kelp, 2800-5200 parts of thunberg fritillary bulb, 3500-6500 parts of coix seeds, 3500-6500 parts of cortex eucommiae, 3500-6500 parts of dogwood, 2800-5200 parts of hemlock parsley, 3500-6500 parts of airpotato yam, 4900-9100 parts of angelica sinensis and 4200-7800 parts of fermented soybeans. The pharmaceutical composition for treating hyperthyroidism provided by the invention adopts a method with combination of Chinese traditional and western medicine, gives full play to the synergistic effect of Chinese traditional and western medicine, reduces adverse reaction of the pharmaceutical composition, enhances the curative effect, shortens the course of treatment and increases tolerance of patients.

The invention provides a nano-gold colorimetric method based on the principle of anti-agglomeration and a method for measuring the content of silver ions in water samples. The method comprises the following steps: take 200 μL of the nano-gold solution prepared by sodium citrate reduction, add 200 μL of a certain concentration of methimazole solution, then add 400 μL of BR buffer solution, shake well and incubate for 5 minutes, perform ultraviolet-visible spectrum scanning, and measure the concentration of the solution at 520 The absorbance at nm and 660 nm, the ratio of the absorbance of the solution A 520 / A 660 as A 0 ; Then take 200 μL of methimazole at a certain concentration and 200 μL of silver ion solution at a certain concentration, add 200 μL of BR buffer solution, shake well and incubate for 10 minutes, then add 200 μL nano-gold solution, shake well and incubate for 5 minutes, and perform UV-visible spectrum scanning. Measure the absorbance of the solution at 520 nm and 660 nm, and the absorbance ratio of the solution A 520 / A 660 as A 1 , after adding silver ions, the change of absorbance ratio has a linear relationship with the concentration of silver ions, so the content of silver ions in water samples can be quickly, sensitively and accurately determined. The invention has good selectivity, high sensitivity and wide detection range, only needs ultraviolet spectrophotometer measurement, does not need large-scale instruments, has low operation requirements, and has wide application prospects.

The invention relates to methimazole microemulsion, methimazole microemulsion-based gel and a preparation method and application of the methimazole microemulsion. The methimazole microemulsion comprises methimazole, oil, surfactant, cosurfactant, water and transdermal Enhancer according to a weight ratio of 1:(1.40-4.25):(5.13-15.45):(5.13-15.45):(1.40-8.32):(0.26:1.26). The methimazole microemulsion-based gel is prepared by adding gel matrix into the methimazole microemulsion, allowing swelling and performing uniform mixing. The methimazole microemulsion and the methimazole microemulsion-based gel are directly applicable to affected parts, are also applicable to the preparation of hyperthyroidism pharmaceuticals such as patches or plasters, and have the advantages such as good solubility, high penetration capacity, long acting time, evident improvement in therapeutic effect, fewer times of administration, and convenience of administration.