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Radix hedysari polysaccharide functionalized silver nanoparticle colorimetric sensor as well as preparation method and application thereof in detection of methimazole

A colorimetric sensor, the technology of astragalus polysaccharide, which is applied in the measurement of color/spectral properties, analysis by chemical reaction of materials, and material analysis by observing the influence on chemical indicators, etc., can solve the complex operation and hinder the use of , time-consuming and other issues, to achieve the effect of strong selectivity, easy portability and low cost

Pending Publication Date: 2022-07-29
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are inevitably defects such as time-consuming, complicated operation, and dependence on expensive instruments or equipment.
These common disadvantages hamper their use in reality monitoring

Method used

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  • Radix hedysari polysaccharide functionalized silver nanoparticle colorimetric sensor as well as preparation method and application thereof in detection of methimazole
  • Radix hedysari polysaccharide functionalized silver nanoparticle colorimetric sensor as well as preparation method and application thereof in detection of methimazole
  • Radix hedysari polysaccharide functionalized silver nanoparticle colorimetric sensor as well as preparation method and application thereof in detection of methimazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] 1. The preparation of the astragalus polysaccharide functionalized silver nanoparticle colorimetric sensor (HPS-AgNPs colorimetric sensor) of the present invention is as follows:

[0061] Add 20ml of 0.25mM silver nitrate solution to a 200mL round-bottomed flask, stir with a magnetic stirring heating mantle and heat to 70°C, add sodium hydroxide solution to the solution to adjust the pH of the solution to 12, and rapidly add it to the solution at one time under magnetic stirring. Add 100 μL of Astragalus polysaccharide solution (1g / L) to the mixed solution, and after heating and stirring for 1 hour, the color of the solution gradually changes from transparent to orange-yellow. Stop heating and let the product solution cool at room temperature to obtain an orange-yellow solution, which is HPS- AgNPs colorimetric sensor. Pour the resulting solution into a conical flask or beaker, and place it in a 4°C refrigerator for future use.

[0062] Second, the construction of the ...

Embodiment 2

[0098] The preparation of the astragalus polysaccharide functionalized silver nanoparticle colorimetric sensor (HPS-AgNPs colorimetric sensor) of the present invention is as follows:

[0099] Add 20ml of 0.25mM silver nitrate solution to a 200mL round-bottomed flask, stir with a magnetic stirring heating mantle and heat to 70°C, add sodium hydroxide solution to the solution to adjust the pH of the solution to 10, and rapidly add it to the solution at one time under magnetic stirring. Add 100 μL of Astragalus polysaccharide solution (1g / L) to the mixed solution, and after heating and stirring for 1 hour, the color of the solution gradually changes from transparent to orange-yellow. Stop heating and let the product solution cool at room temperature to obtain an orange-yellow solution, which is HPS- AgNPs colorimetric sensor. Pour the resulting solution into a conical flask or beaker, and place it in a 4°C refrigerator for future use.

Embodiment 3

[0101] The difference between the present invention and Example 2 is that the temperature of the reaction system is heated to 80° C., and the remaining steps and parameters are the same as those of Example 2.

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Abstract

The invention provides a preparation method of a hedysarum polybotrys polysaccharide functionalized silver nanoparticle colorimetric sensor, which comprises the following steps: heating a silver nitrate solution to 60-90 DEG C, adjusting the pH value to 8-14, quickly adding a hedysarum polybotrys polysaccharide solution at one time under stirring for reaction, stopping heating and cooling until the solution is changed from transparent to orange yellow, and filtering to obtain a silver nitrate solution; the hedysarum polybotrys polysaccharide functionalized silver nanoparticle colorimetric sensor is obtained. An injector paper-based methimazole colorimetric detection device prepared by applying the hedysarum polybotrys polysaccharide functionalized silver nanoparticle colorimetric sensor can be used for quantitatively detecting methimazole. The detection device is low in cost, simple and convenient to operate, high in sensitivity and strong in specificity, is successfully applied to naked eye colorimetric detection of methimazole in human and animal serum, human and animal urine and other samples, and can realize quantitative analysis of colorimetric detection results only through naked eye observation or application of a smart phone and computer software in a real scene; or estimating the concentration of methimazole by using a colorimetric card.

Description

technical field [0001] The invention relates to a colorimetric sensor of heptostilbene polysaccharide functionalized silver nanoparticles, a preparation method thereof, and an application in detecting methimazole. Background technique [0002] Thiamazole, also known as tapazole, is a commonly used drug for the treatment of hyperthyroidism, which is the second most common disease among human endocrine system diseases today. It is worth noting that during the treatment of this drug, due to the narrow therapeutic window of methimazole, high plasma concentrations of methimazole may cause nausea, dizziness, diarrhea and even nephritis, lupus erythematosus syndrome and thrombocytopenia. Therefore, monitoring the concentration of the therapeutic drug throughout the treatment process is particularly critical. In order to monitor the accurate concentration of methimazole, rapid and sensitive detection methods have high practical significance. [0003] The reported methods for the d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/31G01N21/78
CPCG01N21/31G01N21/78
Inventor 赵良功陈心悦季佳慧封士兰
Owner LANZHOU UNIVERSITY
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