Methimazole microemulsion, methimazole microemulsion-based gel and preparation method and application of methimazole microemulsion
A technology of methimazole and microemulsion gel, which is applied in the field of microemulsion gel transdermal preparation and its preparation, and the field of methimazole microemulsion for the treatment of hyperthyroidism, which can solve the problem of limited transdermal application and difficult penetration of hydrophilic drugs Skin and other problems, to achieve the effect of reducing the number of administration, improving drug loading capacity and improving curative effect
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Embodiment 1
[0039]
[0040] Preparation Process:
[0041] 1) Weigh the oil phase, surfactant, and co-surfactant of the prescription amount, and mix evenly under magnetic stirring;
[0042] 2) Weigh the prescribed amount of water and add it dropwise to the above-mentioned mixed solution, and after mixing evenly under magnetic stirring, a blank microemulsion solution is obtained;
[0043] 3) Add the prescribed amount of transdermal accelerator into the microemulsion solution, and mix evenly under magnetic stirring;
[0044] 4) Add the prescribed amount of methimazole raw material drug into the blank microemulsion, the ultrasonic temperature is 25°C, and after 5 minutes of complete dissolution, a transparent drug-containing microemulsion solution is obtained;
[0045] 5) Add the prescribed amount of gel matrix into the above microemulsion, and stir evenly after it is fully swollen to obtain a uniform microemulsion gel.
Embodiment 2
[0047]
[0048] Preparation method: with embodiment 1
Embodiment 3
[0050]
[0051] Preparation method: with embodiment 1
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